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Thrombopoietin receptor

Summary

UniProt ID: Q08351
Gene Symbol: Mpl Tpor
Gene ID: 17480
Organism: Mus musculus (house mouse)

External Links

PubChem: Q08351
Re-Glyco: Q08351

Annotation

Keyword: 3D-structure Alternative splicing Cell membrane Glycoprotein Golgi apparatus Isopeptide bond Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane helix Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	Reference
neutrophil homeostasis	ISO	GO_REF
positive regulation of gene expression	IMP	PMID
platelet formation	IGI	PMID
platelet formation	IBA	GO_REF
regulation of chemokine production	IMP	PMID

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

myeloid cell homeostasis [inference]

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway [inference]

thrombopoietin-mediated signaling pathway

G protein-coupled receptor signaling pathway [inference]

chemokine-mediated signaling pathway [inference]

thrombopoietin-mediated signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

platelet formation

cell development [inference]

hemopoiesis [inference]

definitive hemopoiesis

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells

leukocyte homeostasis [inference]

myeloid cell homeostasis [inference]

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

platelet formation

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

definitive hemopoiesis

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

platelet formation

cell development [inference]

hemopoiesis [inference]

definitive hemopoiesis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells

leukocyte homeostasis [inference]

myeloid cell homeostasis [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

positive regulation of lymphocyte proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

positive regulation of myeloid cell differentiation [inference]

positive regulation of platelet formation

regulation of platelet formation [inference]

positive regulation of platelet formation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of platelet formation

positive regulation of myeloid cell differentiation [inference]

positive regulation of platelet formation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of platelet formation

positive regulation of myeloid cell differentiation [inference]

positive regulation of platelet formation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of platelet formation

regulation of platelet formation [inference]

positive regulation of platelet formation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of platelet formation

positive regulation of myeloid cell differentiation [inference]

positive regulation of platelet formation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of platelet formation

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

positive regulation of myeloid cell differentiation [inference]

positive regulation of platelet formation

regulation of platelet formation [inference]

positive regulation of platelet formation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of platelet formation

positive regulation of myeloid cell differentiation [inference]

positive regulation of platelet formation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

positive regulation of myeloid cell differentiation [inference]

positive regulation of platelet formation

regulation of platelet formation [inference]

positive regulation of platelet formation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway [inference]

thrombopoietin-mediated signaling pathway

G protein-coupled receptor signaling pathway [inference]

chemokine-mediated signaling pathway [inference]

thrombopoietin-mediated signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation

regulation of lymphocyte proliferation [inference]

positive regulation of lymphocyte proliferation

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation

regulation of stem cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of platelet formation

positive regulation of myeloid cell differentiation [inference]

positive regulation of platelet formation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of platelet formation

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

positive regulation of myeloid cell differentiation [inference]

positive regulation of platelet formation

regulation of platelet formation [inference]

positive regulation of platelet formation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of leukocyte proliferation [inference]

positive regulation of mononuclear cell proliferation [inference]

positive regulation of lymphocyte proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of platelet formation

positive regulation of myeloid cell differentiation [inference]

positive regulation of platelet formation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

positive regulation of lymphocyte proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation

regulation of cell division [inference]

regulation of stem cell division

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of chemokine production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

positive regulation of lymphocyte proliferation

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

positive regulation of lymphocyte proliferation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

positive regulation of myeloid cell differentiation [inference]

positive regulation of platelet formation

regulation of platelet formation [inference]

positive regulation of platelet formation

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
Golgi apparatus	ISS	GO_REF
Golgi apparatus	ISO	GO_REF
Golgi apparatus	IEA	GO_REF
plasma membrane	ISS	GO_REF
plasma membrane	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane

organelle membrane [inference]

nuclear membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

cell body [inference]

neuronal cell body

side of membrane [inference]

external side of plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	Reference
thrombopoietin receptor activity	ISS	GO_REF
thrombopoietin receptor activity	ISO	GO_REF
thrombopoietin receptor activity	IBA	GO_REF

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

thrombopoietin receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

thrombopoietin receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPSWALFMVTSCLLLALPNQAQVTSQDVFLLALGTEPLNCFSQTFEDLTCFWDEEEAAPSGTYQLLYAYRGEKPRACPLYSQSVPTFGTRYVCQFPAQDEVRLFFPLHLWVKNVSLNQTLIQRVLFVDSVGLPAPPRVIKARGGSQPGELQIHWEAPAPEISDFLRHELRYGPTDSSNATAPSVIQLLSTETCCPTLWMPNPVPVLDQPPCVHPTASQPHGPAPFLTVKGGSCLVSGLQAGKSYWLQLRSQPDGVSLRGSWGPWSFPVTVDLPGDAVTIGLQCFTLDLKMVTCQWQQQDRTSSQGFFRHSRTRCCPTDRDPTWEKCEEEEPRPGSQPALVSRCHFKSRNDSVIHILVEVTTAQGAVHSYLGSPFWIHQAVLLPTPSLHWREVSSGRLELEWQHQSSWAAQETCYQLRYTGEGREDWKVLEPSLGARGGTLELRPRARYSLQLRARLNGPTYQGPWSAWSPPARVSTGSETAWITLVTALLLVLSLSALLGLLLLKWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPSKATVTDSCEEVEPSLLEILPKSSESTPLPLCPSQPQMDYRGLQPCLRTMPLSVCPPMAETGSCCTTHIANHSYLPLSYWQQP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
117	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0090118	congenital amegakaryocytic thrombocytopenia	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements