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Platelet endothelial cell adhesion molecule

Summary

UniProt ID: Q08481
Gene Symbol: Pecam1 Pecam Pecam-1
Gene ID: 18613
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003930
GlyGen: Q08481
PubChem: Q08481
RaftProt: Q08481
Re-Glyco: Q08481

Annotation

Keyword: Alternative splicing Cell adhesion Cell junction Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Immunoglobulin domain Palmitate Phosphoprotein Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 55 in total

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GO Term	Evidence Code	Reference
angiogenesis	IDA	PMID
angiogenesis	IMP	PMID
endothelial cell morphogenesis	IMP	PMID
positive regulation of leukocyte migration	ISO	GO_REF
positive regulation of cellular extravasation	ISO	GO_REF

GO Hierarchy

biological process

immune system process [inference]

immune response

leukocyte migration [inference]

cellular extravasation [inference]

diapedesis

mononuclear cell migration [inference]

monocyte extravasation

myeloid leukocyte migration [inference]

monocyte extravasation

granulocyte migration [inference]

neutrophil migration [inference]

neutrophil extravasation

cellular process [inference]

cell adhesion

cell-substrate adhesion [inference]

cell-matrix adhesion [inference]

endothelial cell-matrix adhesion

cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Rho protein signal transduction

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier

cell motility [inference]

cell migration [inference]

endothelial cell migration

leukocyte migration [inference]

cellular extravasation [inference]

diapedesis

mononuclear cell migration [inference]

monocyte extravasation

myeloid leukocyte migration [inference]

monocyte extravasation

granulocyte migration [inference]

neutrophil migration [inference]

neutrophil extravasation

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

bicellular tight junction assembly

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

bicellular tight junction assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

bicellular tight junction assembly

tight junction organization [inference]

tight junction assembly [inference]

bicellular tight junction assembly

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis [inference]

epithelial cell morphogenesis [inference]

endothelial cell morphogenesis

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier

animal gross anatomical part developmental process [inference]

tissue development [inference]

epithelium development [inference]

endothelium development [inference]

glomerular endothelium development

kidney epithelium development [inference]

nephron epithelium development [inference]

glomerular epithelium development [inference]

glomerular endothelium development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

wound healing

immune response

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus

response to mechanical stimulus [inference]

cellular response to external stimulus [inference]

cellular response to mechanical stimulus

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of mechanical stimulus

response to mechanical stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus

detection of abiotic stimulus [inference]

detection of mechanical stimulus

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

import into cell [inference]

endocytosis [inference]

phagocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration

positive regulation of cellular extravasation

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration

positive regulation of cellular extravasation

regulation of cellular extravasation [inference]

positive regulation of cellular extravasation

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of localization [inference]

regulation of protein localization [inference]

regulation of protein localization to cell-cell junction [inference]

positive regulation of protein localization to cell-cell junction

positive regulation of protein localization [inference]

positive regulation of protein localization to cell-cell junction

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration

positive regulation of cellular extravasation

regulation of cell motility [inference]

regulation of cell migration

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration

positive regulation of cellular extravasation

regulation of cellular extravasation [inference]

positive regulation of cellular extravasation

positive regulation of cell migration

positive regulation of leukocyte migration

positive regulation of cellular extravasation

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration

positive regulation of cellular extravasation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration

positive regulation of cellular extravasation

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration

positive regulation of cellular extravasation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration

positive regulation of cellular extravasation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of protein localization [inference]

positive regulation of protein localization to cell-cell junction

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament polymerization

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament polymerization

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

small GTPase-mediated signal transduction [inference]

Rho protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration

positive regulation of cellular extravasation

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament polymerization

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament polymerization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament polymerization

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament polymerization

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament polymerization

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament polymerization

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament polymerization

regulation of cell motility [inference]

regulation of cell migration

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration

positive regulation of cellular extravasation

regulation of cellular extravasation [inference]

positive regulation of cellular extravasation

positive regulation of cell migration

positive regulation of leukocyte migration

positive regulation of cellular extravasation

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of leukocyte migration

positive regulation of cellular extravasation

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	Reference
ruffle	ISO	GO_REF
obsolete extracellular space
nucleoplasm	ISO	GO_REF
nucleolus	ISO	GO_REF
cytoplasm	IDA	PMID

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

membrane

plasma membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

anchoring junction [inference]

cell-cell junction

cell-cell contact zone

cell projection [inference]

plasma membrane bounded cell projection [inference]

ruffle

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

contractile muscle fiber [inference]

smooth muscle contractile fiber

intracellular organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

contractile muscle fiber [inference]

smooth muscle contractile fiber

cell periphery

side of membrane [inference]

external side of plasma membrane

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

contractile muscle fiber [inference]

smooth muscle contractile fiber

Displaying **all 4** entries
GO Term	Evidence Code	Reference
transmembrane signaling receptor activity	IBA	GO_REF
protein phosphatase binding	ISO	GO_REF
protein homodimerization activity	ISO	GO_REF
protein homodimerization activity	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MLLALGLTLVLYASLQAEENSFTINSIHMESLPSWEVMNGQQLTLECLVDISTTSKSRSQHRVLFYKDDAMVYNVTSREHTESYVIPQARVFHSGKYKCTVMLNNKEKTTIEYEVKVHGVSKPKVTLDKKEVTEGGVVTVNCSLQEEKPPIFFKIEKLEVGTKFVKRRIDKTSNENFVLMEFPIEAQDHVLVFRCQAGILSGFKLQESEPIRSEYVTVQESFSTPKFEIKPPGMIIEGDQLHIRCIVQVTHLVQEFTEIIIQKDKAIVATSKQSSEAVYSVMAMVEYSGHYTCKVESNRISKASSIMVNITELFPKPKLEFSSSRLDQGELLDLSCSVSGTPVANFTIQKEETVLSQYQNFSKIAEESDSGEYSCTAGIGKVVKRSGLVPIQVCEMLSKPSIFHDAKSEIIKGHAIGISCQSENGTAPITYHLMKAKSDFQTLEVTSNDPATFTDKPTRDMEYQCRADNCHSHPAVFSEILRVRVIAPVDEVVISILSSNEVQSGSEMVLRCSVKEGTSPITFQFYKEKEDRPFHQAVVNDTQAFWHNKQASKKQEGQYYCTASNRASSMRTSPRSSTLAVRVFLAPWKKGLIAVVVIGVVIATLIVAAKCYFLRKAKAKQKPVEMSRPAAPLLNSNSEKISEPSVEANSHYGYDDVSGNDAVKPINQNKDPQNMDVEYTEVEVSSLEPHQALGTRATETVYSEIRKVDPNLMENRYSRTEGSLNGT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
74	N-linked (GlcNAc...) asparagine	19349973	G80920RR	GlycoProtDB UniProt GlyGen
141	N-linked (GlcNAc...) asparagine	19349973	G25079LO	GlycoProtDB UniProt GlyGen
309	N-linked (GlcNAc...) asparagine		G24748EV	GlycoProtDB UniProt GlyGen
345	N-linked (GlcNAc...) asparagine		G15664MX	GlycoProtDB UniProt GlyGen
360	N-linked (GlcNAc...) asparagine	19349973	G72747WU	GlycoProtDB UniProt GlyGen
424	N-linked (GlcNAc...) asparagine	19349973		GlycoProtDB UniProt GlyGen
540	N-linked (GlcNAc...) asparagine	19349973	G31986NC	GlycoProtDB UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Cell surface interactions at the vascular wall	Mus musculus
Integrin cell surface interactions	Mus musculus
Neutrophil degranulation	Mus musculus
PECAM1 interactions	Mus musculus
Platelet degranulation	Mus musculus
Platelet sensitization by LDL	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

International Collaboration

Acknowledgements