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Sphingomyelin phosphodiesterase

Summary

UniProt ID: Q0VD19
Gene Symbol: SMPD1
Gene ID: 505097
Organism: Bos taurus (domestic cattle)

External Links

PubChem: Q0VD19
Re-Glyco: Q0VD19

Annotation

Keyword: Disulfide bond Glycoprotein Glycosidase Lipid droplet Lipid metabolism Lysosome Metal-binding Phosphoprotein Reference proteome Secreted Signal Zinc

Gene Ontology (GO)

Displaying entries **1 - 5** of 36 in total

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GO Term	Evidence Code	Reference
plasma membrane repair	ISS	GO_REF
plasma membrane repair	IEA	GO_REF
sphingomyelin catabolic process	ISS	GO_REF
sphingomyelin catabolic process	IBA	GO_REF
sphingomyelin catabolic process	IEA	GO_REF GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

catabolic process [inference]

lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

phospholipid catabolic process [inference]

sphingomyelin catabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingomyelin metabolic process [inference]

sphingomyelin catabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

lipid catabolic process [inference]

phospholipid catabolic process [inference]

sphingomyelin catabolic process

sphingolipid catabolic process [inference]

sphingomyelin catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

plasma membrane organization [inference]

plasma membrane repair

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

symbiont entry into host [inference]

symbiont entry into host cell

response to other organism [inference]

response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

pyroptotic inflammatory response

response to wounding [inference]

wound healing

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

cellular response to UV

cellular response to light stimulus [inference]

cellular response to UV

response to ionizing radiation

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

response to chemical [inference]

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

response to peptide [inference]

response to cytokine [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

positive regulation of transport [inference]

positive regulation of endocytosis

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of viral process [inference]

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of viral life cycle [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

termination of signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
obsolete extracellular space
lysosome	IDA	PMID
lysosome	IBA	GO_REF
lysosome	IEA	GO_REF GO_REF
lysosomal membrane	IDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

membrane microdomain [inference]

membrane raft

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

endolysosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endolysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

endolysosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endolysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

endolysosome

intracellular membraneless organelle [inference]

lipid droplet

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GO Term	Evidence Code	Reference
sphingomyelin phosphodiesterase activity	ISS	GO_REF
sphingomyelin phosphodiesterase activity	IEA	GO_REF GO_REF GO_REF GO_REF
zinc ion binding	ISS	GO_REF
zinc ion binding	IEA	GO_REF
hydrolase activity, acting on glycosyl bonds

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

glycerophospholipase activity [inference]

C-type glycerophospholipase activity [inference]

phosphatidylcholine phospholipase C activity

sphingophospholipase activity [inference]

sphingomyelin phosphodiesterase activity

acid sphingomyelin phosphodiesterase activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

C-type glycerophospholipase activity [inference]

phosphatidylcholine phospholipase C activity

sphingomyelin phosphodiesterase activity

acid sphingomyelin phosphodiesterase activity

hydrolase activity, acting on glycosyl bonds

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPRHGVSPGQGLPRSGREQASDRSLGAPCLRLLWLGLALALALPNSPVLWSPAEARPLPTQGHPAKFIRIAPQLQEAFGWWNLTCPTCKGLFTAIDFGLRNQASVAWVGSVAIKLCVLLKIAPPAVCQSAVQLFEDDMVEVWTRSVLSPSEACGLLLGSSCGHWDIFSSWNISLPAVPKPPPQPPKPPAPGSPVSRVLFLTDLHWDHDYLEGTDPNCENPLCCRRDSGPPPASQPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHNIWQQSRQDQLRALTTITALVKKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSHWLYEAMAEAWEPWLPAEALRTLRIGGFYALSPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVERYENTLAGQFFGHTHVDEFEVFYDEETLSRPLSVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYIMNLTEANEPGATPHWYLLYRARETYGLPNALPTAWHDLVYRMRKDTQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARSDSPALCRHLVPDASLPDVQSLWSMPLLC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	Source
82	N-linked (GlcNAc...) asparagine	UniProt
171	N-linked (GlcNAc...) asparagine	UniProt
331	N-linked (GlcNAc...) asparagine	UniProt
391	N-linked (GlcNAc...) asparagine	UniProt
499	N-linked (GlcNAc...) asparagine	UniProt
516	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Glycosphingolipid catabolism	Bos taurus
Regulation of clotting cascade	Bos taurus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements