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FAS-associated death domain protein

Summary

UniProt ID

Q13158

Gene Symbol

FADD
MORT1

Organism

Homo sapiens (human)

External Links

GlyGen: Q13158
PubChem: Q13158
The O-GlcNAc Database: Q13158

Annotation

Keyword

3D-structure
Apoptosis
Disease variant
Glycoprotein
Host-virus interaction
Innate immunity
Phosphoprotein
Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 10** of 38 in total

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GO Term
kidney development
positive regulation of T cell mediated cytotoxicity
positive regulation of adaptive immune response
apoptotic process
T cell homeostasis
innate immune response
positive regulation of innate immune response
apoptotic signaling pathway
positive regulation of type II interferon production
positive regulation of interleukin-8 production

Displaying **all 8** entries
GO Term
cytoplasm
plasma membrane
cell body
death-inducing signaling complex
CD95 death-inducing signaling complex
cytosol
cytoplasmic side of plasma membrane
ripoptosome

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GO Term
identical protein binding
death receptor binding
tumor necrosis factor receptor binding
tumor necrosis factor receptor superfamily binding
signaling adaptor activity
receptor serine/threonine kinase binding
death effector domain binding
caspase binding
protease binding
protein-containing complex binding

Annotation information from UniProt.

Sequence

MDPFLVLLHSVSSSLSSSELTELKFLCLGRVGKRKLERVQSGLDLFSMLLEQNDLEPGHTELLRELLASLRRHDLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDSIEDRYPRNLTERVRESLRIWKNTEKENATVAHLVGALRSCQMNLVADLVQEVQQARDLQNRSGAMSPMSWNSDASTSEAS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
117	(Microbial infection) N-beta-linked (GlcNAc) arginine	23955153 24025841 28860194 30979585		UniProt
155			G62765YT	GlyGen
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 14 in total

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Pathway Name	Organism
CASP8 activity is inhibited	Homo sapiens
Defective RIPK1-mediated regulated necrosis	Homo sapiens
Dimerization of procaspase-8	Homo sapiens
FasL/ CD95L signaling	Homo sapiens
Ligand-dependent caspase activation	Homo sapiens
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	Homo sapiens
RIPK1-mediated regulated necrosis	Homo sapiens
Regulation by c-FLIP	Homo sapiens
Regulation of TNFR1 signaling	Homo sapiens
Regulation of necroptotic cell death	Homo sapiens