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Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

Summary

UniProt ID: Q13683
Gene Symbol: ITGA7 UNQ406/PRO768
Gene ID: 3679
Organism: Homo sapiens (human)

External Links

GlyGen: Q13683
PubChem: Q13683
Re-Glyco: Q13683

Annotation

Keyword: ADP-ribosylation Alternative splicing Calcium Cell adhesion Cell shape Cleavage on pair of basic residues Congenital muscular dystrophy Direct protein sequencing Disulfide bond Glycoprotein Integrin Metal-binding Proteomics identification Receptor Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
cell-matrix adhesion	TAS	PMID
cell-matrix adhesion	IEA	GO_REF
integrin-mediated signaling pathway	IBA	GO_REF
muscle organ development	TAS	PMID PMID
regulation of cell shape

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

cell-cell adhesion

heterotypic cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

endodermal cell differentiation

cell motility [inference]

cell migration [inference]

leukocyte migration

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

muscle organ development

muscle structure development [inference]

muscle organ development

cellular developmental process [inference]

cell differentiation [inference]

endodermal cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of biological quality [inference]

regulation of cell shape

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
plasma membrane	TAS	Reactome Reactome Reactome
plasma membrane	IEA	GO_REF
integrin complex	IBA	GO_REF
integrin complex	IEA	GO_REF
cell surface	IC	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

protein complex involved in cell adhesion [inference]

integrin complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	Reference
signaling receptor activity	IBA	GO_REF
metal ion binding

GO Hierarchy

molecular function

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRKEGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPGGKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKGTARVELCAQGSADLAHLDDGPYEAGGEKEQDPRLIPVPANSYFGLLFVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGERLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPNCAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPMDVDGTTALFALSGQPVIGLELMVTNLPSDPAQPQADGDDAHEAQLLVMLPDSLHYSGVRALDPAEKPLCLSNENASHVECELGNPMKRGAQVTFYLILSTSGISIETTELEVELLLATISEQELHPVSARARVFIELPLSIAGMAIPQQLFFSGVVRGERAMQSERDVGSKVKYEVTVSNQGQSLRTLGSAFLNIMWPHEIANGKWLLYPMQVELEGGQGPGQKGLCSPRPNILHLDVDSRDRRRRELEPPEQQEPGERQEPSMSWWPVSSAEKKKNITLDCARGTANCVVFSCPLYSFDRAAVLHVWGRLWNSTFLEEYSAVKSLEVIVRANITVKSSIKNLMLRDASTVIPVMVYLDPMAVVAEGVPWWVILLAVLAGLLVLALLVLLLWKMGFFKRAKHPEATVPQYHAVKIPREDRQQFKEEKTGTILRNNWGSPRREGPDAHPILAADGHPELGPDGHPGPGTA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
86	N-linked (GlcNAc...) asparagine			UniProt GlyGen
786	N-linked (GlcNAc...) asparagine		G80920RR	UniProt GlyGen
989	N-linked (GlcNAc...) asparagine	37074911	G01650EU G28541PG G31852PQ G41247ZX	UniProt GlyGen
1025	N-linked (GlcNAc...) asparagine	19159218 37074911	G46503DX G80920RR G62765YT	UniProt GlyGen
1045	N-linked (GlcNAc...) asparagine	37074911	G00912UN G80920RR G62765YT G31852PQ G41247ZX	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
ECM proteoglycans	Homo sapiens
Integrin cell surface interactions	Homo sapiens
Laminin interactions	Homo sapiens

Disease

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:11723	Duchenne muscular dystrophy	Alliance of Genome Resources
DOID:0110639	congenital muscular dystrophy due to integrin alpha-7 deficiency	Alliance of Genome Resources
DOID:0080000	muscular disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements