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MIRAGE
Low-density lipoprotein receptor-related protein 8
Summary
- UniProt ID
- Q14114
- Gene Symbol
- APOER2 LRP8
- Gene ID
- 7804
- Organism
- Homo sapiens (human)
Annotation
- Keyword
- 3D-structure Alternative splicing Calcium Cell membrane Disulfide bond EGF-like domain Endocytosis Glycoprotein Host-virus interaction Metal-binding Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Secreted Signal Transmembrane helix Ubl conjugation
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| retinoid metabolic process | ||
| proteolysis | ||
| lipid metabolic process | ||
| lipid metabolic process | ||
| endocytosis |
GO Hierarchy
biological process
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
positive regulation of biological process [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| obsolete extracellular space |
|
|
| microtubule associated complex | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| amyloid-beta binding |
|
|
| transmembrane signaling receptor activity | ||
| transmembrane signaling receptor activity | ||
| low-density lipoprotein particle receptor activity | ||
| low-density lipoprotein particle receptor activity |
GO Hierarchy
Sequence
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDDGLP
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 84 |
|
|||
| 85 |
|
|||
| 176 |
|
|||
| 287 |
|
|||
| 428 |
|
|
||
| 441 |
|
|
||
| 514 |
|
|||
| 516 |
|
|||
| 518 |
|
|||
| 538 |
|
|
G57321FI
G80920RR
G49108TO
G27058EU
G90659AW
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Platelet sensitization by LDL | Homo sapiens |
| Retinoid metabolism and transport | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:3393 | coronary artery disease | |
| DOID:5419 | schizophrenia | |
| DOID:1307 | dementia | |
| DOID:10652 | Alzheimer's disease | |
| DOID:5844 | myocardial infarction |
