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Transforming growth factor-beta-induced protein ig-h3

Summary

UniProt ID: Q15582
Gene Symbol: BIGH3 TGFBI
Gene ID: 7045
Organism: Homo sapiens (human)

External Links

GlyGen: Q15582
PubChem: Q15582
The Human Metabolome Database: HMDBP07469
RaftProt: Q15582
Re-Glyco: Q15582

Annotation

Keyword: 3D-structure Amyloid Amyloidosis Cell adhesion Corneal dystrophy Direct protein sequencing Disease variant Disulfide bond Extracellular matrix Gamma-carboxyglutamic acid Phosphoprotein Proteomics identification Reference proteome Repeat Signal Vision

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
angiogenesis	IEP	PMID
chondrocyte differentiation	IEA	GO_REF
cell adhesion
negative regulation of cell adhesion	TAS	PMID
visual perception	TAS	PMID

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion

regulation of cellular process [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion

negative regulation of cellular process [inference]

negative regulation of cell adhesion

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GO Term	Evidence Code	Reference
extracellular region	EXP	PMID PMID PMID
extracellular region	TAS	PMID Reactome
extracellular region	IDA	PMID
extracellular region	IEA	GO_REF GO_REF
extracellular region	HDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix

basement membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	Reference
integrin binding	TAS	PMID
extracellular matrix structural constituent	RCA	PMID PMID PMID PMID PMID PMID
extracellular matrix structural constituent	ISS	GO_REF
collagen binding	IPI	PMID
identical protein binding	IPI	PMID

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

identical protein binding

cell adhesion molecule binding

integrin binding

protein-containing complex binding [inference]

extracellular matrix binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MALFVRLLALALALALGPAATLAGPAKSPYQLVLQHSRLRGRQHGPNVCAVQKVIGTNRKYFTNCKQWYQRKICGKSTVISYECCPGYEKVPGEKGCPAALPLSNLYETLGVVGSTTTQLYTDRTEKLRPEMEGPGSFTIFAPSNEAWASLPAEVLDSLVSNVNIELLNALRYHMVGRRVLTDELKHGMTLTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVISTITNNIQQIIEIEDTFETLRAAVAASGLNTMLEGNGQYTLLAPTNEAFEKIPSETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGLSVETLEGTTLEVGCSGDMLTINGKAIISNKDILATNGVIHYIDELLIPDSAKTLFELAAESDVSTAIDLFRQAGLGNHLSGSERLTLLAPLNSVFKDGTPPIDAHTRNLLRNHIIKDQLASKYLYHGQTLETLGGKKLRVFVYRNSLCIENSCIAAHDKRGRYGTLFTMDRVLTPPMGTVMDVLKGDNRFSMLVAAIQSAGLTETLNREGVYTVFAPTNEAFRALPPRERSRLLGDAKELANILKYHIGDEILVSGGIGALVRLKSLQGDKLEVSLKNNVVSVNKEPVAEPDIMATNGVVHVITNVLQPPANRPQERGDELADSALEIFKQASAFSRASQRSVRLAPVYQKLLERMKH

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
28		23584533	G57321FI	GlyGen
656		23584533	G57321FI	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Amyloid fiber formation	Homo sapiens

Disease

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0080530	granular corneal dystrophy 1	Alliance of Genome Resources
DOID:0060444	granular corneal dystrophy 2	Alliance of Genome Resources
DOID:0060447	epithelial basement membrane dystrophy	Alliance of Genome Resources
DOID:0060455	Thiel-Behnke corneal dystrophy	Alliance of Genome Resources
DOID:2566	corneal dystrophy	Alliance of Genome Resources
DOID:0060453	Reis-Bucklers corneal dystrophy	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Acknowledgements