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Integrin alpha-5

Summary

UniProt ID: Q27977
Gene Symbol: ITGA5
Gene ID
Organism: Bos taurus (domestic cattle)

External Links

Re-Glyco: Q27977

Annotation

Keyword: Calcium Cell adhesion Cell junction Cell membrane Cleavage on pair of basic residues Disulfide bond Glycoprotein Integrin Metal-binding Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	Reference
angiogenesis	IBA	GO_REF
autophagy
cell-substrate junction assembly
heterophilic cell-cell adhesion
leukocyte cell-cell adhesion

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion

cell adhesion mediated by integrin

cell-cell adhesion mediated by integrin

cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

metabolic process [inference]

catabolic process [inference]

autophagy

cellular developmental process [inference]

cell differentiation [inference]

endodermal cell differentiation

cell motility [inference]

cell migration [inference]

wound healing, spreading of cells [inference]

wound healing, spreading of epidermal cells

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-substrate junction assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-substrate junction assembly

cell-substrate junction organization [inference]

cell-substrate junction assembly

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory

behavior [inference]

learning or memory [inference]

memory

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

cellular developmental process [inference]

cell differentiation [inference]

endodermal cell differentiation

response to stimulus [inference]

response to activity [inference]

response to muscle activity

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of vascular endothelial growth factor signaling pathway [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of autophagy

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of anoikis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of vascular endothelial growth factor signaling pathway [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to vascular endothelial growth factor stimulus [inference]

regulation of vascular endothelial growth factor signaling pathway [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of vascular endothelial growth factor signaling pathway [inference]

positive regulation of vascular endothelial growth factor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of autophagy

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of autophagy

regulation of autophagy [inference]

negative regulation of autophagy

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of anoikis

regulation of anoikis [inference]

negative regulation of anoikis

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of anoikis

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of vascular endothelial growth factor signaling pathway

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of autophagy

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of anoikis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	Reference
endoplasmic reticulum	IEA	GO_REF
Golgi apparatus	IEA	GO_REF
plasma membrane	ISS	GO_REF
plasma membrane	TAS	Reactome Reactome Reactome Reactome Reactome Reactome
plasma membrane	IEA	GO_REF GO_REF GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex [inference]

integrin alpha5-beta1 complex

protein complex involved in cell adhesion [inference]

integrin complex [inference]

integrin alpha5-beta1 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex [inference]

integrin alpha5-beta1 complex

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

cell junction [inference]

synapse

anchoring junction [inference]

cell-cell junction

cell-substrate junction [inference]

focal adhesion

leading edge membrane [inference]

ruffle membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

side of membrane [inference]

external side of plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	Reference
integrin binding	IEA	GO_REF
calcium ion binding	IEA	GO_REF
signaling receptor activity	IBA	GO_REF
signaling receptor activity	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding [inference]

integrin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

integrin binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MREEGGGSREKEGESPNPPSLTQSRQPASSWGWGEGSGEVRPPHAPSGWGARAQRSRDPGMPPRPPPRQAGGGLSREFGKLLPALSHSPLGGLGSGSGSVAPGQGRAGAMGSRTPGSPLHAVQLRRGARRRPRLLPLLPPLLLLLLPPPPRVGGFNLDAEAPAVLSGPPGSFFGFSVEFYRPGTDGVSVLVGAPKANTSQPGVLQGGAVYLCPWGTSPAQCTPIEFDSKGSRIFESSTSSSEGEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKEPQSDPVGTCYLSTGNFTQILEYAPCRSDFSQEAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQIAESYYPGYLINPVRGQLQTRQASSIYDDSYLGYSVAVGEFSGDDREDFVAGVPKGNLTYGYVTILNGSDIRSLYNFSGEQMASYFGYAVAATDINGDGLDDLLVGAPLLMERTADGRPQEVGRVYIYLQRLAGMEPTPTLTLTGQDEFGRFGSSLTPLGDLDQDGYNDVAIGAAFGGENRQGVVFIFPGGPGGLASKPSQVLLPLWAAGHTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKAVVYRGRPIVSASASLTIFPAMFNPEEHSCSLEGNPVTCINLSFCLNASGKHVPDSIGFTVELQLDWQKQKGGVRRALFLASRQATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLDPQAPVDSHGLRPVLHYQSKSRIEDKAQILLDCGEDNICVPDLQLEVFGEQNHVYLGDKNSLNLTFHAQNVGEGGAYEAELRVTAPPEAEYSGLVRHPGNFSSLSCDYFAVNQSRLLVCDLGNPMKAGASLWGGLRFTVPHLRDTKKTIQFDFQILSKNLNNSQSDVVSFRLSVEAQAQVSLNGVSKPEAVLFPMSDWHPQDQPQEEGDVGPAVHHVYELINLGPSSISQGVLELSCPHALDGQQLLYVTRVTGLSNCTTSHPPNPEGLELDPEGSQHHRLQRRDVPGRSPASSGPQILKCPEAECFKLRCELGPLHRQESRSLQLHFRVWAKTFLQREHQPFSLQCEAVYEALKMPYKILPRQLPQKALQVATAVQWIKAEGSHGVPLWIIILAILIGLLLLGLLIYILYKLGFFKRSLPYGTAMEKAQLKPPATSDA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 14 in total

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Position	Description	Source
197	N-linked (GlcNAc...) asparagine	UniProt
295	N-linked (GlcNAc...) asparagine	UniProt
410	N-linked (GlcNAc...) asparagine	UniProt
420	N-linked (GlcNAc...) asparagine	UniProt
429	N-linked (GlcNAc...) asparagine	UniProt
637	N-linked (GlcNAc...) asparagine	UniProt
643	N-linked (GlcNAc...) asparagine	UniProt
706	N-linked (GlcNAc...) asparagine	UniProt
722	N-linked (GlcNAc...) asparagine	UniProt
788	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Cell surface interactions at the vascular wall	Bos taurus
Elastic fibre formation	Bos taurus
Fibronectin matrix formation	Bos taurus
GPER1 signaling	Bos taurus
Integrin cell surface interactions	Bos taurus
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Bos taurus

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