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Patatin-like phospholipase domain-containing protein 2

Summary

UniProt ID: Q2KI18
Gene Symbol: ATGL PNPLA2
Gene ID: 508493
Organism: Bos taurus (domestic cattle)

External Links

PubChem: Q2KI18
Re-Glyco: Q2KI18

Annotation

Keyword: Cell membrane Cytoplasm Glycoprotein Hydrolase Isopeptide bond Lipid degradation Lipid droplet Phosphoprotein Reference proteome Signal-anchor Transmembrane helix Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
diacylglycerol biosynthetic process	ISS	GO_REF
negative regulation of triglyceride storage
positive regulation of triglyceride catabolic process	IEA	GO_REF
triglyceride catabolic process	ISS	GO_REF
triglyceride catabolic process	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

lipid catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

lipid catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

triglyceride catabolic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

triglyceride catabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

lipid droplet organization [inference]

lipid droplet fusion

organelle fusion [inference]

lipid droplet fusion

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular triglyceride homeostasis

chemical homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular triglyceride homeostasis

lipid homeostasis

acylglycerol homeostasis [inference]

triglyceride homeostasis [inference]

intracellular triglyceride homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of lipid localization [inference]

negative regulation of lipid localization [inference]

negative regulation of lipid storage [inference]

negative regulation of triglyceride storage

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of lipid storage [inference]

negative regulation of triglyceride storage

negative regulation of lipid localization [inference]

negative regulation of lipid storage [inference]

negative regulation of triglyceride storage

regulation of cellular process [inference]

regulation of lipid storage [inference]

negative regulation of lipid storage [inference]

negative regulation of triglyceride storage

regulation of triglyceride storage [inference]

negative regulation of triglyceride storage

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of lipid catabolic process [inference]

regulation of triglyceride catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

positive regulation of lipid metabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of lipid catabolic process [inference]

regulation of triglyceride catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of lipid metabolic process [inference]

positive regulation of lipid catabolic process [inference]

positive regulation of triglyceride catabolic process

positive regulation of triglyceride metabolic process [inference]

positive regulation of triglyceride catabolic process

negative regulation of cellular process [inference]

negative regulation of lipid storage [inference]

negative regulation of triglyceride storage

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
cytoplasm	ISS	GO_REF
cytoplasm	IEA	GO_REF GO_REF
lipid droplet	ISS	GO_REF
lipid droplet	IBA	GO_REF
lipid droplet	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane

plasma membrane

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membraneless organelle [inference]

lipid droplet

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
A2-type glycerophospholipase activity	ISS	GO_REF
A2-type glycerophospholipase activity	IEA	GO_REF GO_REF
triacylglycerol lipase activity	ISS	GO_REF
triacylglycerol lipase activity	IBA	GO_REF
triacylglycerol lipase activity	IEA	GO_REF GO_REF GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity [inference]

acylglycerol O-acyltransferase activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

triacylglycerol lipase activity

phospholipase activity [inference]

glycerophospholipase activity [inference]

A2-type glycerophospholipase activity

carboxylic ester hydrolase activity [inference]

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MFPKETTWNISFAGCGFLGVYHIGVASCLREHAPFLVANATHIYGASAGALTATALVTGACLGEAGANIIEVSKEARKRFLGPLHPSFNMVKTIRGCLLKILPADCYECASGRLGISLTRVSDGENVIITHFNSKEELIQANVCSTFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELKNTITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCKQGYRDGLRFLRRNGLLNRPNPLLALPPSQPPAPEDADAQEGAVAMERTGGKDHLPPPREDHILEHLPSRLNEALLEACMEPTDLLTTLSNMLPVRLAMAMMVPYTLPLESAVSFTIRLLEWLPDVPEDIRWMKEQTGSICQYLMIRAKRKLGNHLPSRLSGQVVLRRARSLPSVPLSCAAYSEVLPSWMRNSLSLGDVLAKWEECQRQLLLGLFCTNVAFPPDALRMRVPAGPAPEPPQHPPSSPPC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites