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Platelet glycoprotein 4

Summary

UniProt ID: Q3UAI3
Gene Symbol: Cd36
Gene ID: 12491
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0004666
Re-Glyco: Q3UAI3

Annotation

Keyword: Cell adhesion Cell membrane Disulfide bond Glycoprotein Golgi apparatus Isopeptide bond Lipid transport Palmitate Receptor Transmembrane helix Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	Reference
positive regulation of cell-matrix adhesion	IEA	GO_REF
receptor-mediated endocytosis	IEA	GO_REF
cell adhesion
positive regulation of macrophage derived foam cell differentiation
long-chain fatty acid import across plasma membrane	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

nitric oxide mediated signal transduction [inference]

nitric oxide-cGMP-mediated signaling

metabolic process [inference]

catabolic process [inference]

amyloid-beta clearance by cellular catabolic process

amyloid-beta metabolic process [inference]

amyloid-beta clearance by cellular catabolic process

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to amyloid-beta

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to bacterial lipoprotein [inference]

cellular response to bacterial lipopeptide [inference]

cellular response to diacyl bacterial lipopeptide

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus [inference]

cellular response to oxidised low-density lipoprotein particle stimulus

transmembrane transport [inference]

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

nutrient storage [inference]

lipid storage

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

lipid transport across blood-brain barrier

plasma lipoprotein particle clearance [inference]

amyloid-beta clearance [inference]

amyloid-beta clearance by cellular catabolic process

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to bacterial lipoprotein [inference]

response to bacterial lipopeptide [inference]

cellular response to bacterial lipopeptide [inference]

cellular response to diacyl bacterial lipopeptide

response to diacyl bacterial lipopeptide [inference]

cellular response to diacyl bacterial lipopeptide

cellular response to bacterial lipoprotein [inference]

cellular response to bacterial lipopeptide [inference]

cellular response to diacyl bacterial lipopeptide

cellular response to molecule of bacterial origin [inference]

cellular response to bacterial lipoprotein [inference]

cellular response to bacterial lipopeptide [inference]

cellular response to diacyl bacterial lipopeptide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to bacterial lipoprotein [inference]

response to bacterial lipopeptide [inference]

cellular response to bacterial lipopeptide [inference]

cellular response to diacyl bacterial lipopeptide

response to diacyl bacterial lipopeptide [inference]

cellular response to diacyl bacterial lipopeptide

cellular response to bacterial lipoprotein [inference]

cellular response to bacterial lipopeptide [inference]

cellular response to diacyl bacterial lipopeptide

cellular response to molecule of bacterial origin [inference]

cellular response to bacterial lipoprotein [inference]

cellular response to bacterial lipopeptide [inference]

cellular response to diacyl bacterial lipopeptide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to bacterial lipoprotein [inference]

cellular response to bacterial lipopeptide [inference]

cellular response to diacyl bacterial lipopeptide

response to endogenous stimulus [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus [inference]

cellular response to oxidised low-density lipoprotein particle stimulus

response to chemical [inference]

response to lipoprotein particle [inference]

cellular response to low-density lipoprotein particle stimulus [inference]

cellular response to oxidised low-density lipoprotein particle stimulus

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to amyloid-beta

response to nitrogen compound [inference]

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

response to oxygen-containing compound [inference]

cellular response to oxygen-containing compound [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to amyloid-beta

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to bacterial lipoprotein [inference]

cellular response to bacterial lipopeptide [inference]

cellular response to diacyl bacterial lipopeptide

cellular response to lipoprotein particle stimulus [inference]

cellular response to low-density lipoprotein particle stimulus [inference]

cellular response to oxidised low-density lipoprotein particle stimulus

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

lipoprotein transport

lipoprotein localization [inference]

lipoprotein transport

establishment of localization [inference]

transport [inference]

lipid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

lipid import into cell [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

lipid transport across blood-brain barrier

vascular transport [inference]

transport across blood-brain barrier [inference]

lipid transport across blood-brain barrier

protein transport [inference]

lipoprotein transport

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

transmembrane transport [inference]

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

establishment of protein localization [inference]

protein transport [inference]

lipoprotein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

negative regulation of biological process [inference]

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of response to external stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

nitric oxide mediated signal transduction [inference]

nitric oxide-cGMP-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell differentiation [inference]

positive regulation of macrophage derived foam cell differentiation

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

Displaying **all 5** entries
GO Term	Evidence Code	Reference
Golgi apparatus	IEA	GO_REF GO_REF
cell surface	IEA	GO_REF
apical plasma membrane	IEA	GO_REF
signaling receptor complex	IEA	GO_REF
membrane raft	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane region [inference]

apical plasma membrane

membrane microdomain [inference]

membrane raft

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
amyloid-beta binding	IEA	GO_REF
low-density lipoprotein particle receptor activity	IEA	GO_REF
scavenger receptor activity	IEA	GO_REF
lipid binding	IEA	GO_REF
short-chain fatty acid transmembrane transporter activity	IEA	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

fatty acid transmembrane transporter activity [inference]

long-chain fatty acid transmembrane transporter activity [inference]

oleate transmembrane transporter activity

short-chain fatty acid transmembrane transporter activity

lipid transmembrane transporter activity [inference]

fatty acid transmembrane transporter activity [inference]

long-chain fatty acid transmembrane transporter activity [inference]

oleate transmembrane transporter activity

short-chain fatty acid transmembrane transporter activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

Toll-like receptor binding

lipid binding

peptide binding [inference]

amyloid-beta binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding [inference]

low-density lipoprotein particle binding

cargo receptor activity [inference]

scavenger receptor activity

lipoprotein particle receptor activity [inference]

molecular transducer activity [inference]

signaling receptor activity [inference]

thrombospondin receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGCDRNCGLIAGAVIGAVLAVFGGILMPVGDMLIEKTIKREVVLEEGTTAFKNWVKTGTTVYRQFWIFDVQNPDDVAKNSSKIKVKQRGPYTYRVRYLAKENITQDPEDHTVSFVQPNGAIFEPSLSVGTEDDNFTVLNLAVAAAPHIYQNSFVQVVLNSLIKKSKSSMFQTRSLKELLWGYKDPFLSLVPYPISTTVGVFYPYNDTVDGVYKVFNGKDNISKVAIIESYKGKRNLSYWPSYCDMINGTDAASFPPFVEKSRTLRFFSSDICRSIYAVFGSEIDLKGIPVYRFVLPANAFASPLQNPDNHCFCTEKVISNNCTSYGVLDIGKCKEGKPVYISLPHFLHASPDVSEPIEGLHPNEDEHRTYLDVEPITGFTLQFAKRLQVNILVKPARKIEALKNLKRPYIVPILWLNETGTIGDEKAEMFKTQVTGKIKLLGMVEMALLGIGVVMFVAFMISYCACKSKNGK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
79				GlycoProtDB
102				GlycoProtDB
220				GlycoProtDB
235				GlycoProtDB
247				GlycoProtDB
320				GlycoProtDB
321				GlycoProtDB
417				GlycoProtDB

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements