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Prolyl 3-hydroxylase 1

Summary

UniProt ID: Q3V1T4
Gene Symbol: P3h1 Gros1 Lepre1
Gene ID: 56401
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0005048
PubChem: Q3V1T4
Re-Glyco: Q3V1T4

Annotation

Keyword: Alternative splicing Coiled coil Dioxygenase Endoplasmic reticulum Extracellular matrix Iron Metal-binding Proteoglycan Reference proteome Repeat Signal TPR repeat Vitamin C

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	Reference
protein folding	ISO	GO_REF
protein folding	IEA	GO_REF
positive regulation of neuron projection development	ISO	GO_REF
collagen fibril organization	IMP	PMID
regulation of ossification	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

protein folding

metabolic process [inference]

collagen metabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

developmental process [inference]

anatomical structure development [inference]

animal gross anatomical part developmental process [inference]

animal organ development [inference]

bone development

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of protein secretion

regulation of protein transport [inference]

regulation of protein secretion

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

negative regulation of cell growth

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of post-translational protein modification [inference]

negative regulation of post-translational protein modification

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

regulation of post-translational protein modification [inference]

negative regulation of post-translational protein modification

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification

negative regulation of cell growth

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of secretion by cell [inference]

regulation of protein secretion

regulation of multicellular organismal process [inference]

regulation of ossification

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
basement membrane	ISO	GO_REF
nucleus	ISO	PMID
cytoplasm	ISO	PMID
endoplasmic reticulum	ISO	PMID GO_REF GO_REF
endoplasmic reticulum	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix [inference]

basement membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 5** entries
GO Term	Evidence Code	Reference
iron ion binding	IEA	GO_REF
procollagen-proline 3-dioxygenase activity	ISO	PMID GO_REF
procollagen-proline 3-dioxygenase activity	IBA	GO_REF
procollagen-proline 3-dioxygenase activity	IEA	GO_REF GO_REF GO_REF
L-ascorbic acid binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

peptidyl-proline 3-dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

peptidyl-proline 3-dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

catalytic activity, acting on a protein [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

peptidyl-proline 3-dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

binding [inference]

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAVSERRLLAAMLAVAAAAALRVAAESEPGWDVAAPDLLYAEGTAAYSRGDWPGVVLNMERALRSRAALRALRLRCRTRCATELPWAPDLDLGPDPSLSQDPGAAALHDLRFFGAVLRRAACLRRCLGPPSAHLLSEELDLEFNKRSPYNYLQVAYFKINKLEKAVAAAHTFFVGNPEHMEMRQNLDYYQTMSGVKEADFRDLEAKPHMHEFRLGVRLYSEEKPQEAVPHLEAALQEYFVADEECRALCEGPYDYDGYNYLDYSADLFQAITDHYVQVLNCKQNCVTELASHPSREKPFEDFLPSHYNYLQFAYYNIGNYTQAIECAKTYLLFFPNDEVMHQNLAYYTAMLGEEEASSISPRENAEEYRRRSLLEKELLFFAYDIFGIPFVDPDSWTPEEVIPKRLQEKQKSERETAVRISQEIGNLMKEIETLVEEKTKESLDVSRLTREGGPLLYEGISLTMNSKVLNGSQRVVMDGVISDDECQELQRLTNAAATSGDGYRGQTSPHTPNEKFYGVTVLKALKLGQEGKVPLQSARMYYNVTEKVRRVMESYFRLDTPLYFSYSHLVCRTAIEESQAERKDSSHPVHVDNCILNAEALMCIKEPPAYTFRDYSAILYLNGDFDGGNFYFTELDAKTVTAEVQPQCGRAVGFSSGTENPHGVKAVTRGQRCAIALWFTLDPRHSERDRVQADDLVKMLFSPEEVDLPQEQPLPDQQGSPEPGEESLSDRGSLHKDEL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
319	N-linked (GlcNAc...) asparagine	UniProt
470	N-linked (GlcNAc...) asparagine	UniProt
543	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Collagen biosynthesis and modifying enzymes	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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International Collaboration

Acknowledgements