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Prelamin-A/C [Cleaved into: Lamin-A/C]

Summary

UniProt ID: Q3ZD69
Gene Symbol: LMNA
Gene ID
Organism: Sus scrofa (pig)

External Links

Re-Glyco: Q3ZD69

Annotation

Keyword: Acetylation Alternative splicing Coiled coil Glycoprotein Intermediate filament Isopeptide bond Methylation Nucleus Phosphoprotein Prenylation Reference proteome Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
nuclear envelope organization	ISS	GO_REF
nuclear envelope organization	IBA	GO_REF
nuclear migration	IBA	GO_REF
heterochromatin formation	IBA	GO_REF
protein localization to nucleus	ISS	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell cycle process [inference]

chromosome attachment to the nuclear envelope [inference]

DNA double-strand break attachment to nuclear envelope

cellular localization [inference]

intracellular transport [inference]

nuclear migration

localization within membrane [inference]

nuclear pore localization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

heterochromatin organization [inference]

heterochromatin formation

organelle organization [inference]

nucleus organization [inference]

nuclear pore localization

cellular component assembly [inference]

heterochromatin formation

membrane organization [inference]

nuclear envelope organization

cellular senescence

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus

protein localization to nuclear envelope

protein-containing complex localization [inference]

nuclear pore localization

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

nuclear migration

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear migration

establishment of organelle localization [inference]

nuclear migration

organelle localization [inference]

chromosome localization [inference]

chromosome attachment to the nuclear envelope [inference]

DNA double-strand break attachment to nuclear envelope

nucleus localization [inference]

nuclear migration

establishment of organelle localization [inference]

nuclear migration

cellular localization [inference]

intracellular transport [inference]

nuclear migration

localization within membrane [inference]

nuclear pore localization

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

negative regulation of response to stimulus [inference]

negative regulation of muscle adaptation [inference]

negative regulation of cardiac muscle adaptation [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

negative regulation of multicellular organismal process [inference]

negative regulation of muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

negative regulation of muscle adaptation [inference]

negative regulation of cardiac muscle adaptation [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

regulation of response to stimulus [inference]

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

regulation of cardiac muscle hypertrophy in response to stress [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

regulation of cardiac muscle adaptation [inference]

negative regulation of cardiac muscle adaptation [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

regulation of cardiac muscle hypertrophy in response to stress [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

negative regulation of muscle adaptation [inference]

negative regulation of cardiac muscle adaptation [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

negative regulation of response to stimulus [inference]

negative regulation of muscle adaptation [inference]

negative regulation of cardiac muscle adaptation [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

regulation of response to stress [inference]

regulation of cardiac muscle hypertrophy in response to stress [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle hypertrophy [inference]

regulation of cardiac muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

regulation of cardiac muscle hypertrophy in response to stress [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

negative regulation of muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

regulation of cardiac muscle hypertrophy in response to stress [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

regulation of cardiac muscle adaptation [inference]

negative regulation of cardiac muscle adaptation [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

regulation of cardiac muscle hypertrophy in response to stress [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

negative regulation of muscle adaptation [inference]

negative regulation of cardiac muscle adaptation [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

negative regulation of multicellular organismal process [inference]

negative regulation of muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

negative regulation of muscle adaptation [inference]

negative regulation of cardiac muscle adaptation [inference]

negative regulation of cardiac muscle hypertrophy in response to stress

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
nucleus	ISS	GO_REF
nuclear envelope	ISS	GO_REF
nuclear envelope	IEA	GO_REF GO_REF
nuclear lamina	ISS	GO_REF
nuclear lamina	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

site of DNA damage [inference]

site of double-strand break

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

Displaying **all 2** entries
GO Term	Evidence Code	Reference
structural constituent of cytoskeleton	IBA	GO_REF
structural constituent of nuclear lamina	ISS	GO_REF

GO Hierarchy

molecular function

structural molecule activity [inference]

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKSAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLMAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTLKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQDLRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLADKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQSGGSVTKKRKLESSESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPADLVWKSQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTMIEDDEDEDGDDLLHHHHGSHGSSSGDPAEYNLRSRTVLCGTCGQPADKASASSSGAQVGGSISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSRPRTQSPQNCSIM

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
625	O-linked (GlcNAc) serine			UniProt
628	O-linked (GlcNAc) serine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Breakdown of the nuclear lamina	Sus scrofa
Depolymerization of the Nuclear Lamina	Sus scrofa
Initiation of Nuclear Envelope (NE) Reformation	Sus scrofa
Nuclear Envelope Breakdown	Sus scrofa