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Endothelin-converting enzyme 1

Summary

UniProt ID: Q4PZA2
Gene Symbol: Ece1
Gene ID: 230857
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0005131

GlyConnect

Endothelin-converting enzyme 1

GlyGen

Q4PZA2

PubChem

Q4PZA2

RaftProt

Q4PZA2

Re-Glyco

Q4PZA2

Annotation

Keyword: Alternative splicing Cell membrane Disulfide bond Glycoprotein Metal-binding Metalloprotease Phosphoprotein Reference proteome Signal-anchor Transmembrane helix Zinc

Gene Ontology (GO)

Displaying entries **1 - 5** of 40 in total

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GO Term	Evidence Code	Reference
response to hypoxia	ISO	GO_REF
positive regulation of receptor recycling	ISO	GO_REF GO_REF
positive regulation of receptor recycling	IEA	GO_REF
axon guidance	IMP	PMID
heart development	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

catabolic process [inference]

bradykinin catabolic process

hormone catabolic process

calcitonin catabolic process

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

hormone metabolic process [inference]

peptide hormone processing

endothelin maturation

hormone catabolic process

calcitonin catabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

endothelin maturation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

axonogenesis involved in innervation

plasma membrane bounded cell projection organization [inference]

neuron projection development

neuron projection guidance [inference]

axon guidance

sympathetic neuron axon guidance

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

embryonic digit morphogenesis

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

axonogenesis involved in innervation

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

embryonic heart tube development

tube development [inference]

embryonic heart tube development

animal organ development [inference]

sensory organ development [inference]

ear development

heart development

system development [inference]

pharyngeal system development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of receptor recycling [inference]

positive regulation of receptor recycling

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP/PKA signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

regulation of cAMP/PKA signal transduction [inference]

positive regulation of cAMP/PKA signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP/PKA signal transduction

positive regulation of signaling [inference]

positive regulation of receptor recycling

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP/PKA signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of receptor recycling

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP/PKA signal transduction

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP/PKA signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP/PKA signal transduction

positive regulation of multicellular organismal process [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP/PKA signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

regulation of cAMP/PKA signal transduction [inference]

positive regulation of cAMP/PKA signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP/PKA signal transduction

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP/PKA signal transduction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP/PKA signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

regulation of cAMP/PKA signal transduction [inference]

positive regulation of cAMP/PKA signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP/PKA signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP/PKA signal transduction

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

regulation of macromolecule metabolic process [inference]

regulation of receptor recycling [inference]

positive regulation of receptor recycling

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cAMP/PKA signal transduction

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle hypertrophy [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

regulation of muscle adaptation [inference]

regulation of cardiac muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

positive regulation of multicellular organismal process [inference]

positive regulation of muscle hypertrophy [inference]

positive regulation of cardiac muscle hypertrophy

regulation of biological quality [inference]

regulation of blood pressure

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

endothelin maturation

hormone catabolic process

calcitonin catabolic process

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	Reference
endosome	ISO	GO_REF
endosome	IEA	GO_REF
early endosome	ISO	GO_REF GO_REF
Golgi apparatus	ISS	PMID
plasma membrane	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell surface

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

early endosome

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule

Weibel-Palade body

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

early endosome

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule

Weibel-Palade body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

early endosome

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule

Weibel-Palade body

perinuclear region of cytoplasm

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
endopeptidase activity	ISO	GO_REF
endopeptidase activity	IEA	GO_REF
metalloendopeptidase activity	ISO	GO_REF
metalloendopeptidase activity	IBA	GO_REF
metalloendopeptidase activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

protein binding [inference]

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRTVWSPLAAALAALGMSTYKRATLDEEDLVDSLSEGDVYPNGLQVNFRSSRSGQRCWAARTSVEKRLVVLVTLLAAGLVACLAALGIQYQTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAVIKHLLENATASVSEAERKAQVYYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLRQVSTLINNTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCIPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIIMEIKKAFEESLSTLKWMDEETRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQTLPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPHHKCEVW

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
165	N-linked (GlcNAc...) asparagine	19349973 30899004	G83460ZZ G05724UK G39188ZX G06110VR	GlycoProtDB UniProt GlyGen GlyConnect
186	N-linked (GlcNAc...) asparagine		G02815KT	GlycoProtDB UniProt GlyGen
209	N-linked (GlcNAc...) asparagine	19349973 30899004	G06110VR	GlycoProtDB UniProt GlyGen GlyConnect
269	N-linked (GlcNAc...) asparagine		G80920RR	GlycoProtDB UniProt GlyGen
315	N-linked (GlcNAc...) asparagine	19656770		GlycoProtDB UniProt GlyGen
361	N-linked (GlcNAc...) asparagine	19349973 19656770		UniProt GlyGen
382	N-linked (GlcNAc...) asparagine	19656770	G80920RR	GlycoProtDB UniProt GlyGen
538	N-linked (GlcNAc...) asparagine	30899004	G06110VR	GlycoProtDB UniProt GlyGen GlyConnect
631	N-linked (GlcNAc...) asparagine		G77547TA	UniProt GlyGen
650	N-linked (GlcNAc...) asparagine			UniProt GlyGen