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MIRAGE

A disintegrin and metalloproteinase with thrombospondin motifs 18

Summary

UniProt ID: Q4VC17
Gene Symbol: Adamts18
Gene ID: 208936
Organism: Mus musculus (house mouse)

External Links

Re-Glyco: Q4VC17

Annotation

Keyword: Disulfide bond Extracellular matrix Glycoprotein Metal-binding Metalloprotease Reference proteome Repeat Signal Zinc Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

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GO Term	Evidence Code	Reference
eye development	ISO	GO_REF
eye development	IEA	GO_REF
proteolysis	IBA	GO_REF
proteolysis	IEA	GO_REF
extracellular matrix organization	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

sensory organ development [inference]

eye development

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of homotypic cell-cell adhesion [inference]

negative regulation of platelet aggregation

negative regulation of cell activation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of cell activation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of cellular process [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of homotypic cell-cell adhesion [inference]

negative regulation of platelet aggregation

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of homotypic cell-cell adhesion [inference]

negative regulation of platelet aggregation

regulation of homotypic cell-cell adhesion [inference]

negative regulation of homotypic cell-cell adhesion [inference]

negative regulation of platelet aggregation

regulation of platelet aggregation [inference]

negative regulation of platelet aggregation

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of homotypic cell-cell adhesion [inference]

negative regulation of platelet aggregation

negative regulation of cell activation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of cell activation [inference]

regulation of platelet activation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of platelet aggregation [inference]

negative regulation of platelet aggregation

negative regulation of cell activation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of cell activation [inference]

regulation of platelet activation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of platelet aggregation [inference]

negative regulation of platelet aggregation

negative regulation of cell activation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of cell activation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation [inference]

negative regulation of platelet aggregation

Displaying 1 entry
GO Term	Evidence Code	Reference
extracellular matrix	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

external encapsulating structure [inference]

extracellular matrix

Displaying **all 3** entries
GO Term	Evidence Code	Reference
metalloendopeptidase activity	IBA	GO_REF
metalloendopeptidase activity	IEA	GO_REF
metal ion binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MECALLCLCALRAAGPGPPWGPAGLGRLAKALQLCCFCCASVAVALASDSGSSGGSGLNDDYVFVVPVEVDSGGSYISHDILHHRKRRSAHGASNSLHYRVSAFGQDLHLELKPSAILSSHFRVQVLGKDGASETREPEVPQCLYQGFIRNDSSSSVAVSTCAGLSGLIRTRDNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEKRVRWYQDYPGSQRTYPGHSPSHTPPASQSQEPEYSHRRWQKRHFCGRRKKYAPKPPAEDAYLRFDEYGGTGRPRRSAGKSQNGLNVETLVVADAKMVEKHGKDDVTTYILTVMNMVSSLFKDGTIGSDINIVVVSLILLEEEPEGLLINHHADQSLNSFCQWQSALVGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMVHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQTGQYKYPDKLPGQIYDADMQCKWQFGAKAKLCSLGVMKDICKSLWCHRVGHRCETKFMPAAEGTACGLSMWCRQGQCVKLGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCSNPKPQYGGKYCPGSSRIYKLCNINPCPENSLDFRAQQCAEYNNKPFRGWLYRWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPHRNDVCIDGICELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLSQHKANEYYPVVTIPAGARSIEIQELQLSSSYLAVRSLSQKYYLTGGWSIDWPGDFTFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILTQGKNPGIAWKYALPKVMNVTQPATKRYHHTWRTVQSDCSVTCGGGYISIKAICLRDQHTQVNSSFCSVRTKPATEPKICNAFSCPAYWLPGEWSACSKSCAGGQQSRKIRCVQKKPFQKEEAVLHSLCPVSTPTQVQVCNSHACPPEWSPSPWSQCSKTCGRGVRRREVLCKSPAAETLPESLCSSSPRPEAQEGCVLGRCPKNNRLQWIASAWSECSATCGLGVRKRELKCVEKTLQGKLITFPERRCRNIKKPSLELEEACNQRTCPVYSMAVASWYSSPWQQCTVTCGGGVQTRSVHCMQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKKDDPSCVDFFSWCHLVPQHGVCNHKFYGKQCCRSCTRKS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
151	N-linked (GlcNAc...) asparagine			UniProt
190	N-linked (GlcNAc...) asparagine			UniProt
745	N-linked (GlcNAc...) asparagine			UniProt
838	N-linked (GlcNAc...) asparagine			UniProt
865	N-linked (GlcNAc...) asparagine			UniProt
909	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
O-glycosylation of TSR domain-containing proteins	Mus musculus

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026