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TGF-beta receptor type-2

Summary

UniProt ID: Q543C0
Gene Symbol: Tgfbr2
Gene ID: 21813
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0005191
Re-Glyco: Q543C0

Annotation

Keyword: ATP-binding Apoptosis Cell membrane Differentiation Disulfide bond Glycoprotein Growth regulation Magnesium Manganese Metal-binding Phosphoprotein Receptor Serine/threonine-protein kinase Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
vasculogenesis	IEA	GO_REF
apoptotic process
transforming growth factor beta receptor signaling pathway	IEA	GO_REF
positive regulation of cell population proliferation	IEA	GO_REF
lung development	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

lung development

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

response to stimulus [inference]

response to chemical [inference]

response to lipid

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of developmental process

regulation of developmental process [inference]

positive regulation of developmental process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of multicellular organismal process

Displaying **all 4** entries
GO Term	Evidence Code	Reference
plasma membrane	IEA	GO_REF
cell surface	IEA	GO_REF
signaling receptor complex	IEA	GO_REF
membrane raft	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane

membrane microdomain [inference]

membrane raft

Displaying **all 3** entries
GO Term	Evidence Code	Reference
transforming growth factor beta receptor activity, type II	IEA	GO_REF GO_REF
ATP binding	IEA	GO_REF GO_REF
metal ion binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity [inference]

transforming growth factor beta receptor activity, type II

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity [inference]

transforming growth factor beta receptor activity, type II

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity [inference]

transforming growth factor beta receptor activity, type II

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity [inference]

transforming growth factor beta receptor activity, type II

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity [inference]

transforming growth factor beta receptor activity, type II

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity [inference]

transforming growth factor beta receptor activity, type II

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity [inference]

transforming growth factor beta receptor activity, type II

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGRGLLRGLWPLHIVLWTRIASTIPPHVPKSDVEMEAQKDASIHLSCNRTIHPLKHFNSDVMASDNGGAVKLPQLCKFCDVRLSTCDNQKSCMSNCSITAICEKPHEVCVAVWRKNDKNITLETVCHDPKLTYHGFTLEDAASPKCVMKEKKRAGETFFMCACNMEECNDYIIFSEEYTTSSPDLLLVIIQVTGVSLLPPLGIAIAVIIIFYCYRVHRQQKLSPSWESSKPRKLMDFSDNCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYSSWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDSVLRDRGRPEIPSFWLNHQGIQIVCETLTECWDHDPEARLTAQCVAERFSELEHPERLSGRSCSQEKIPEDGSLNTTK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites