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Erlin-1

Summary

UniProt ID: Q58EG2
Gene Symbol: erlin1 si:ch211-223p8.2 zgc:110547
Gene ID: 541490
Organism: Danio rerio (zebrafish)

External Links

PubChem: Q58EG2
Re-Glyco: Q58EG2

Annotation

Keyword: Cholesterol metabolism Endoplasmic reticulum Glycoprotein Lipid-binding Reference proteome Signal-anchor Transmembrane helix

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	Reference
cholesterol metabolic process
SREBP signaling pathway	IBA	GO_REF
SREBP signaling pathway	IEA	GO_REF
negative regulation of cholesterol biosynthetic process	IEA	GO_REF
negative regulation of fatty acid biosynthetic process	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

response to stimulus [inference]

response to stress [inference]

response to sterol depletion [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of ketone metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of steroid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of fatty acid biosynthetic process [inference]

negative regulation of fatty acid biosynthetic process

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of fatty acid biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of fatty acid metabolic process [inference]

negative regulation of fatty acid biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	Reference
endoplasmic reticulum membrane	IBA	GO_REF
endoplasmic reticulum membrane	IEA	GO_REF GO_REF
protein-containing complex	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 2** entries
GO Term	Evidence Code	Reference
cholesterol binding	IBA	GO_REF
ubiquitin protein ligase binding	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAHVGAVVAAMAGLMAILLHSSIHKIEEGHLAVYYRGGALLTSPNGPGYHIMLPFITSYRSVQTTLQTDEIKNVPCGTSGGVMIYFDRIEVVNMLIPTSVVDIVRNYTADYDKTLIFNKIHHELNQFCSVHTLQEVYIELFDIIDENLKTALQKDLNCMAPGLTIQAVRVTKPKIPEAIRRNYELMEAEKTRLLITVQTQKVVEKEAETERKKAIIEAQKVAQVAEIQFQQKVMEKETEKKISEIEDAAFLAREKARADAEYYTAAKFAEANTLKLTPEYLQLMKYQAIAANSKIYFGQDIPNMFVDSSASRPAAGESEQLESLSMRESLKKASKPKASEGH

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
106	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
ABC-family protein mediated transport	Danio rerio
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Danio rerio

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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