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Sodium-driven chloride bicarbonate exchanger

Summary

UniProt ID: Q5DTL9
Gene Symbol: Kiaa4136 Ncbe Slc4a10
Gene ID: 94229
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0005290
Re-Glyco: Q5DTL9

Annotation

Keyword: Alternative promoter usage Alternative splicing Antiport Cell membrane Cell projection Glycoprotein Phosphoprotein Reference proteome Sodium transport Symport Synapse Transmembrane helix Zinc

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
regulation of pH	IDA	PMID
visual perception	IMP	PMID
response to light stimulus	IMP	PMID
post-embryonic development	IMP	PMID
bicarbonate transport	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

central nervous system neuron development [inference]

forebrain neuron development [inference]

pyramidal neuron development

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

behavior [inference]

locomotory behavior [inference]

locomotory exploration behavior

exploration behavior [inference]

locomotory exploration behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

brain morphogenesis

anatomical structure development [inference]

cell development [inference]

neuron development [inference]

central nervous system neuron development [inference]

forebrain neuron development [inference]

pyramidal neuron development

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

central nervous system neuron development [inference]

forebrain neuron development [inference]

pyramidal neuron development

growth [inference]

developmental growth [inference]

multicellular organism growth

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH

monoatomic cation homeostasis [inference]

regulation of pH

regulation of intracellular pH

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

organic anion transport [inference]

bicarbonate transport

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

biological regulation [inference]

regulation of pH

regulation of intracellular pH

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of neuronal synaptic plasticity [inference]

regulation of short-term neuronal synaptic plasticity

regulation of intracellular pH

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GO Term	Evidence Code	Reference
plasma membrane	ISA	PMID
plasma membrane	IDA	PMID
basolateral plasma membrane	ISO	GO_REF
basolateral plasma membrane	EXP	PMID
basolateral plasma membrane	IDA	PMID PMID PMID PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell junction [inference]

synapse

GABA-ergic synapse

somatodendritic compartment

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

perikaryon

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus

presynapse [inference]

axon terminus

postsynapse

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GO Term	Evidence Code	Reference
sodium:bicarbonate symporter activity	ISO	GO_REF GO_REF
sodium:bicarbonate symporter activity	IDA	PMID
sodium:bicarbonate symporter activity	IBA	GO_REF
sodium:bicarbonate symporter activity	IEA	GO_REF
sodium,bicarbonate:chloride antiporter activity	ISO	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:bicarbonate symporter activity

monoatomic cation:bicarbonate symporter activity [inference]

sodium:bicarbonate symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

sodium:bicarbonate symporter activity

sodium,bicarbonate:chloride antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

sodium,bicarbonate:chloride antiporter activity

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:bicarbonate antiporter activity [inference]

sodium,bicarbonate:chloride antiporter activity

bicarbonate:monoatomic anion antiporter activity [inference]

chloride:bicarbonate antiporter activity [inference]

sodium,bicarbonate:chloride antiporter activity

bicarbonate transmembrane transporter activity [inference]

monoatomic cation:bicarbonate symporter activity [inference]

sodium:bicarbonate symporter activity

bicarbonate:monoatomic anion antiporter activity [inference]

chloride:bicarbonate antiporter activity [inference]

sodium,bicarbonate:chloride antiporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:bicarbonate symporter activity

monoatomic cation:bicarbonate symporter activity [inference]

sodium:bicarbonate symporter activity

antiporter activity [inference]

solute:inorganic anion antiporter activity [inference]

chloride:bicarbonate antiporter activity [inference]

sodium,bicarbonate:chloride antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

sodium,bicarbonate:chloride antiporter activity

bicarbonate:monoatomic anion antiporter activity [inference]

chloride:bicarbonate antiporter activity [inference]

sodium,bicarbonate:chloride antiporter activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MEIKDQGAQMEPLLPTRNDEEAVVDRGGTRSILKTHFEKEDLEGHRTLFIGVHVPLGGRKSHRRHRHRGHKHRKRDRERDSGLEDGRESPSFDTPSQRVQFILGTEDDDEEHLPHDLFTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTIEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLANRIPIVRSFADIGKKQSEPNSMDKNAGQVVSPQSAPACAENKNDVSRENSTVDFSKGLGGQQKGHTSPCGMKQRLDKGPPHQQEREVDLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPSRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKIPAVPNGTAAHGEAEPHGGHSGPELQRTGRIFGGLILDIKRKAPFFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSETYPINMHNDLELLTQYSCNCMEPHSPSNDTLKEWRESNLSASDIIWGNLTVSECRSLHGEYVGRACGHGHPYVPDVLFWSVILFFSTVTMSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIGIPSPKLQVPSVFKPTRDDRGWFVTPLGPNPWWTIIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQLFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTVIQMSCLGLLWIIKVSRAAIVFPMMVLALVFVRKLMDFLFTKRELSWLDDLMPESKKKKLEDAEKEEEQSMLAMEDEGTVQLPLEGHYRDDPSVINISDEMSKTAMWGNLLVTADNSKEKESRFPSKSSPS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
677	N-linked (GlcNAc...) asparagine	UniProt
687	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt
697	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Bicarbonate transporters	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements