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Vascular endothelial growth factor receptor 3

Summary

UniProt ID: Q5MD89
Gene Symbol: flt-4 flt4 vegfr3
Gene ID
Organism: Danio rerio (zebrafish)

External Links

PubChem: Q5MD89
Re-Glyco: Q5MD89

Annotation

Keyword: ATP-binding Angiogenesis Cell membrane Cytoplasm Developmental protein Differentiation Disulfide bond Glycoprotein Immunoglobulin domain Nucleus Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane helix Tyrosine-protein kinase

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	Reference
angiogenesis	IEA	GO_REF
vasculature development
lymph vessel development
lymphangiogenesis
sprouting angiogenesis	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

protein autophosphorylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

protein autophosphorylation

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

endothelial cell differentiation [inference]

lymphatic endothelial cell differentiation

cell motility [inference]

cell migration

endothelial cell migration [inference]

blood vessel endothelial cell migration [inference]

venous endothelial cell migration involved in lymph vessel development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

motor neuron axon guidance

developmental process [inference]

anatomical structure morphogenesis [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

sprouting angiogenesis

anatomical structure development [inference]

blood vessel development [inference]

venous blood vessel development

lymph vessel development

regeneration [inference]

tissue regeneration [inference]

cardiac muscle tissue regeneration

atrioventricular canal development

system development [inference]

vasculature development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

endothelial cell differentiation [inference]

lymphatic endothelial cell differentiation

growth [inference]

developmental growth [inference]

tissue regeneration [inference]

cardiac muscle tissue regeneration

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular response to growth factor stimulus [inference]

regulation of vascular endothelial growth factor receptor signaling pathway

regulation of cellular response to vascular endothelial growth factor stimulus [inference]

regulation of vascular endothelial growth factor signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of morphogenesis of an epithelium [inference]

regulation of heart looping

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
nucleus	ISS	GO_REF
nucleus	IEA	GO_REF
cytoplasm	ISS	GO_REF
cytoplasm	IEA	GO_REF
plasma membrane	ISS	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 5** entries
GO Term	Evidence Code	Reference
vascular endothelial growth factor receptor activity	ISS	GO_REF
vascular endothelial growth factor receptor activity	IBA	GO_REF
ATP binding	IEA	GO_REF
growth factor binding	IBA	GO_REF
identical protein binding

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

binding [inference]

protein binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity [inference]

vascular endothelial growth factor receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKRDFTFFCRIWIGIPFFSGLVNGFSMSPPTLDNTKDQLVINANDTLNITCRGQRILDWSWPEESLSKVEFTDRQGQQSPTDTPGYREIRLKECQGVAGKPYCKILILTNAQANDSGYYRCFYKDIKAVIDGTTAASIFVFVRDPEHPFIKRGDNDMETIFITDSETHIEVPCLVSDPDLKVTLFSLVPYPEPVDGSVVTWNNKKGWSIPRHIIQNTSTFIGFYCSISVQNSQHTSSIYVVQVIGLKFYEFKLFPEDSPVELMQGESLVLNCTALVDFNTGVDFQWDYPGKKENRLASLQPLRNVLDEATEISSILSIRNIHLDDSGYYTCWANTLEMKRELTTVVIVHEKPFISLDYRNGSVIEAKEGQKSVRLSVKVSAYPSPEIQWYKNGKLISSKNSSRFKVQQHSLQIRDVCKQDAGEYMLVLKNSPAALEKRLNFTLIVNVPPQIHEKEAAPPTNLYGKGTRQILTCTADGSPPASISWQWRPWSPCDLERTRRALRRRGGRDQSPFCHNWMDLDPEHAVNPIESIDTLTQMVDGKEKTVGRVVIQNASVPAMYKCLAENRVGKDERLIYFYVTTIPEGFDIEMEPSEDPLEQDLVQLKCNADNFTYENLRWYRLDPQTVPPELDCKSLHQYATFLEGQLSFQTTSNNWVLQLNITNIQLQDEGNYVCEVQNRRTGVKHCHRKYIPVKAMEAPRYRHNPTNHTVNVSESLQMNCDVEGTPFPQLSWFKDNQPLHQISGILLQDSNRTLSIQRVREEDAGLYTCSACNQKGCVQSSATVSVIGSDDKTNVEIVILIGTGVIAIFFWVLLLVIFCNVKRVNPADIKTGYLSIIMDPGEVPLEEQCEYLPYDSSQWEISRDRLRLGKVLGHGAFGKVIEASIFGHDKKSSANTVAVKMLKEGATASEHKALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEYCKYGNLSNFLRAKREFFLPYRDRSPKTQSQVRRMIEAGQASQSEHQPSTSSTNPPRVTVDDLWKTPLTIEDLICYSFQVARGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDIYKDPDYVRKGNARLPLKWMAPESIFDKVYTSQSDVWSFGVLLWEIFSLGASPYPGIQIDEDFCKRLKDGTRMRAPDNASPEIYGIMLACWQGEPRERPTFPALVEILGDLLQENSLPEIPFNVSQSSEDDGFSQASSRPPSQEEIRLACNTLPTRYYNCVPFAGCVMVGPSSTCHSRVKTFEELPMEMTSHKTQHDSQTDSGMVLASDELERFEHKHRGAMLTTATTGQSTDRLISCPSVSSSGSGGGLLRPVFFTQLSGQTFYNNEYGHLSEEGVSDYFSSSDQAV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 14 in total

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Position	Description	Source
44	N-linked (GlcNAc...) asparagine	UniProt
48	N-linked (GlcNAc...) asparagine	UniProt
114	N-linked (GlcNAc...) asparagine	UniProt
216	N-linked (GlcNAc...) asparagine	UniProt
271	N-linked (GlcNAc...) asparagine	UniProt
360	N-linked (GlcNAc...) asparagine	UniProt
400	N-linked (GlcNAc...) asparagine	UniProt
440	N-linked (GlcNAc...) asparagine	UniProt
553	N-linked (GlcNAc...) asparagine	UniProt
610	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
VEGF binds to VEGFR leading to receptor dimerization	Danio rerio

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements