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Cystic fibrosis transmembrane conductance regulator

Summary

UniProt ID: Q5U820
Gene Symbol: ABCC7 CFTR
Gene ID: 492302
Organism: Canis lupus familiaris (dog)

External Links

PubChem: Q5U820
Re-Glyco: Q5U820

Annotation

Keyword: ATP-binding Cell membrane Chloride channel Endoplasmic reticulum Endosome Glycoprotein Isomerase Isopeptide bond Nucleus Palmitate Phosphoprotein Reference proteome Repeat Transmembrane helix Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
water transport	IBA	GO_REF
bicarbonate transport	ISS	GO_REF
bicarbonate transport	IBA	GO_REF
bicarbonate transport	IEA	GO_REF GO_REF
response to endoplasmic reticulum stress	ISS	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cellular process involved in reproduction in multicellular organism [inference]

sperm capacitation

cellular developmental process [inference]

cell maturation [inference]

sperm capacitation

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to forskolin

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to ketone [inference]

cellular response to forskolin

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

reproductive process [inference]

developmental process involved in reproduction [inference]

sperm capacitation

multicellular organismal reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

sperm capacitation

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

developmental process [inference]

developmental process involved in reproduction [inference]

sperm capacitation

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

sperm capacitation

cellular developmental process [inference]

cell maturation [inference]

sperm capacitation

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

response to chemical [inference]

response to lipid [inference]

cellular response to lipid [inference]

cellular response to forskolin

response to forskolin [inference]

cellular response to forskolin

response to organophosphorus [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to forskolin

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to ketone [inference]

cellular response to forskolin

response to nitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to cAMP

response to oxygen-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

response to alcohol [inference]

cellular response to alcohol [inference]

cellular response to forskolin

response to forskolin [inference]

cellular response to forskolin

response to ketone [inference]

cellular response to ketone [inference]

cellular response to forskolin

response to forskolin [inference]

cellular response to forskolin

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to ketone [inference]

cellular response to forskolin

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to forskolin

cellular response to nitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to alcohol [inference]

cellular response to forskolin

cellular response to ketone [inference]

cellular response to forskolin

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

organic anion transport [inference]

bicarbonate transport

fluid transport [inference]

water transport

transepithelial water transport

epithelial fluid transport [inference]

transepithelial water transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

transepithelial transport [inference]

epithelial fluid transport [inference]

transepithelial water transport

biological regulation [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH elevation

regulation of biological quality [inference]

regulation of membrane potential [inference]

membrane hyperpolarization

regulation of body fluid levels [inference]

multicellular organismal-level water homeostasis

regulation of intracellular pH [inference]

intracellular pH elevation

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	Reference
nucleus	ISS	GO_REF
nucleus	IEA	GO_REF
early endosome	ISS	GO_REF
endoplasmic reticulum membrane	ISS	GO_REF
endoplasmic reticulum membrane	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

cellular anatomical structure [inference]

cytosol

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

bounding membrane of organelle [inference]

endosome membrane [inference]

plasma membrane region [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
chloride channel activity	ISS	GO_REF
chloride channel activity	IEA	GO_REF
intracellularly ATP-gated chloride channel activity	ISS	GO_REF
intracellularly ATP-gated chloride channel activity	IBA	GO_REF
intracellularly ATP-gated chloride channel activity	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

isomerase activity [inference]

macromolecular conformation isomerase activity [inference]

polypeptide conformation or assembly isomerase activity [inference]

intracellularly ATP-gated chloride channel activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellularly ligand-gated monoatomic ion channel activity [inference]

intracellularly ATP-gated ion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

chloride transmembrane transporter activity

chloride channel activity

intracellularly ATP-gated chloride channel activity

bicarbonate transmembrane transporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellularly ligand-gated monoatomic ion channel activity [inference]

intracellularly ATP-gated ion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

intracellularly ligand-gated monoatomic ion channel activity [inference]

intracellularly ATP-gated ion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

intracellularly ATP-gated chloride channel activity

ATP-gated ion channel activity [inference]

intracellularly ATP-gated ion channel activity [inference]

intracellularly ATP-gated chloride channel activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

chloride channel inhibitor activity

transporter regulator activity [inference]

channel regulator activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

chloride channel inhibitor activity

ion channel regulator activity [inference]

ion channel inhibitor activity [inference]

chloride channel inhibitor activity

chloride channel regulator activity [inference]

chloride channel inhibitor activity

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

chloride channel inhibitor activity

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MQRSPLEKASVLSKLFFSWTRPILIKGYRQRLELSDIYQVPSTDSADHLSEKLEREWDRELASKKNPKLINALRRCFFWRFAFYGILLYLGEVTKAVQPLLLGRIIASYDPDNKQERSIAIYLAIGLCLLFIMRPLLLHPAIFGLHHIGMQIRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVTLLMGLLWDLLQASAFCGLAFLIVLALVQAGLGRMIMKYRDQRAGKINERLVITSEVIENIQSVKAYCWEEAMEKIIENIRQTELKLTRKAAHVRYFNSSAFFFSGFFVVSLSVLPYALIKTIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVMMENVTAFWEEGFGELLEKAKENSNDRKISNGDNSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGVTLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKVLILHEGSCYFYGTFSELQSLRPDFSSKLMGYDSFDQFSPERRNSIITETLRRFSLEGDAAVPWNETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLPMNGIEGESEVPVERRLSLFPDCEQGEAILPRSNMINTGPTLRRQRRQSVLNLMTRSSVNQGQSIHRRTTASTRKMSLAPQANLTEMDIYSRRLSQDSGLEISEEINEEDLKECFFDDVESIPPVTTWNTYLRYITVHKNLIFVLIWCLVIFLAEVAVSLVVLWILRNLSSQDKGNSTQSVNSSYAVIFTSTSAYYIFYIYVGVADTLLALGLFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAVAVVSVLQPYIFLATVPVIAAFIILRAYFLHTSQQLKQLESEGRSPIFTHLLTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRMEIIFVIFFIAVTFISILTTGEGEGTVGIILTLAMNIMGTLQWAVNSSIEVDSLMRSVSRVFKFIDMPTEESKPPTKSFKPSKDAQLSKVTITENRHVREDDIWPSGGQMTVKDLTAKYIDGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSALLRLVNTEGEIQIDGVSWDSIPLQEWRRAFGVIPQKVFIFSGTFRKNLDPYGQWNDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGYVLSHGHKQLMCLARSVLRKAKILLLDEPSAHLDPITYQIIRRTLKQAFADCTVILSEHRIEAMLECQRFLVIEDSRLRQFESIQRLLSERSAFRQAIGPPERPGLLPHRLSSRQRSPSRIAALKEETEDEVQDTRL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
887	N-linked (GlcNAc...) asparagine	UniProt
895	N-linked (GlcNAc...) asparagine	UniProt
901	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
ABC-family protein mediated transport	Canis familiaris
Aggrephagy	Canis familiaris
RHO GTPases regulate CFTR trafficking	Canis familiaris
RHOQ GTPase cycle	Canis familiaris
Ub-specific processing proteases	Canis familiaris

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements