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Receptor tyrosine-protein kinase erbB-2

Summary

UniProt ID: Q60553
Gene Symbol: ERBB2 NEU
Gene ID: 101822760
Organism: Mesocricetus auratus (golden hamster)

External Links

Re-Glyco: Q60553

Annotation

Keyword: ATP-binding Activator Cell membrane Cell projection Cytoplasm Disulfide bond Endosome Glycoprotein Nucleus Phosphoprotein Proto-oncogene Receptor Reference proteome Signal Transcription regulation Transmembrane helix Tyrosine-protein kinase

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	Reference
peripheral nervous system development	IEA	GO_REF
positive regulation of cell population proliferation	IEA	GO_REF
glial cell differentiation	IEA	GO_REF
neuron differentiation	IEA	GO_REF
positive regulation of cell growth	ISS	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

ERBB2 signaling pathway [inference]

ERBB2-ERBB4 signaling pathway

ERBB4 signaling pathway [inference]

ERBB2-ERBB4 signaling pathway

intracellular signal transduction

cellular developmental process [inference]

cell differentiation [inference]

developmental process [inference]

anatomical structure development [inference]

animal organ development

system development [inference]

peripheral nervous system development

cellular developmental process [inference]

cell differentiation [inference]

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

response to epidermal growth factor [inference]

cellular response to epidermal growth factor stimulus

cellular response to growth factor stimulus

cellular response to epidermal growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus

cellular response to epidermal growth factor stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of small GTPase mediated signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein targeting [inference]

regulation of protein targeting to membrane [inference]

positive regulation of protein targeting to membrane

positive regulation of establishment of protein localization [inference]

positive regulation of protein targeting to membrane

regulation of cellular localization [inference]

regulation of protein targeting to membrane [inference]

positive regulation of protein targeting to membrane

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein targeting to membrane

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of small GTPase mediated signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

ERBB2 signaling pathway [inference]

ERBB2-ERBB4 signaling pathway

ERBB4 signaling pathway [inference]

ERBB2-ERBB4 signaling pathway

intracellular signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of small GTPase mediated signal transduction [inference]

positive regulation of small GTPase mediated signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of protein metabolic process [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

regulation of protein metabolic process [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

regulation of microtubule-based process

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase I

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth

regulation of cellular localization [inference]

regulation of protein targeting to membrane [inference]

positive regulation of protein targeting to membrane

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
nucleus	ISS	GO_REF
nucleus	IEA	GO_REF
early endosome	ISS	GO_REF
early endosome	IEA	GO_REF
plasma membrane	ISS	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

basal plasma membrane

cell projection membrane [inference]

ruffle membrane

leading edge membrane [inference]

ruffle membrane

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

perinuclear region of cytoplasm

Displaying **all 3** entries
GO Term	Evidence Code	Reference
RNA polymerase I core binding	ISS	GO_REF
transmembrane receptor protein tyrosine kinase activity	IEA	GO_REF GO_REF
ATP binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

RNA polymerase binding [inference]

RNA polymerase core enzyme binding [inference]

RNA polymerase I core binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MELAAWCGWGLLLALLSPGASGTQVCTGTDMKLRLPASPETHLDIVRHLYQGCQVVQGNLELTYLPANATLSFLQDIQEVQGYMLIAHSQVRHVPLQRLRIVRGTQLFEDKYALAVLDNRDPLDNVTTATGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDTVLWKDVFRKNNQLAPVDIDTNRSRACPPCAPACKDNHCWGASPEDCQTLTGTIAPRAVPAARARLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPLNNQEVTAEDGTQRCEKCSKSCARVCYGLGMEHLRGARAITSANIQEFAGCKKIFGSLAFLPESFDGNPSSGIAPLTPEQLQVFETLEEITGYLYISAWPDSLHDLSVFQNLRVIRGRVLHDGAYSLALQGLGIRWLGLRSLRELGSGLVLIHRNTHLCFVHTVPWDQLFRNPHQALLHSGNPSEEECGLKDFACYPLCAHGHCWGPGPTQCVNCSHFLRGQECVKECRVWKGLPREYVNGKHCLPCHPECQPQNSTETCTGSEADQCTACPHYKDSPFCVARCPSGVKPDLSYMPIWKYPDEEGMCQPCPINCTHSCVDLDERGCPAEQRASPATSIIATVVGILLFLVIGVVVGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGLGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWIALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFFPDPAPGAGSTAHRRHRSSSTRSGGGELTLGMEPSGEEPPRSPLAPSEGAGSDVFEGELGMGATKGPQSISPRDLSPLQRYSEDPTLPLPTETDGYVAPLACSPQPEYVNQPEVRPQPPLTPEGPLPPVRPAGATLERPKTLSPGKNGVVKDVFTFGGAVENPEYLVPRGGSASQPHPPALCPAFDNLYYWDQDPSERGSPPNTFEGTPTAENPEYLGLDVPV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	Source
68	N-linked (GlcNAc...) asparagine	UniProt
125	N-linked (GlcNAc...) asparagine	UniProt
187	N-linked (GlcNAc...) asparagine	UniProt
259	N-linked (GlcNAc...) asparagine	UniProt
530	N-linked (GlcNAc...) asparagine	UniProt
571	N-linked (GlcNAc...) asparagine	UniProt
629	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements