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Frizzled-7

Summary

UniProt ID

Q61090

Gene Symbol

Fzd7

Gene ID

[14369]

Organism

Mus musculus (house mouse)

External Links

PubChem: Q61090
Re-Glyco: Q61090

Annotation

Keyword: Cell membrane Developmental protein Disulfide bond Endosome G-protein coupled receptor Glycoprotein Reference proteome Signal Transmembrane helix Ubl conjugation Wnt signaling pathway

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	Reference
regulation of DNA-templated transcription	ISO	GO_REF
regulation of transcription, DNA-templated	ISO	GO_REF
negative regulation of cell-substrate adhesion	ISO	GO_REF
negative regulation of cell-substrate adhesion	IMP	PMID
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	IMP	PMID

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

cell adhesion [inference]

cell-substrate adhesion [inference]

substrate adhesion-dependent cell spreading

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

epithelial cell differentiation [inference]

mesenchymal to epithelial transition

cell division [inference]

stem cell division [inference]

somatic stem cell division

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

T cell activation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

stem cell population maintenance

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

T cell differentiation in thymus

epithelial cell differentiation [inference]

mesenchymal to epithelial transition

maintenance of cell number [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of Wnt signaling pathway [inference]

regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in wound healing

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of ectodermal cell fate specification

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of ectodermal cell fate specification

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of Wnt signaling pathway [inference]

regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of developmental process [inference]

regulation of cell fate commitment [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of ectodermal cell fate specification

regulation of cell fate specification [inference]

negative regulation of cell fate specification [inference]

negative regulation of ectodermal cell fate specification

regulation of ectodermal cell fate specification [inference]

negative regulation of ectodermal cell fate specification

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of ectodermal cell fate specification

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of muscle cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of striated muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiocyte differentiation [inference]

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of ectodermal cell fate specification

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

regulation of cell fate commitment [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of ectodermal cell fate specification

regulation of cell fate specification [inference]

negative regulation of cell fate specification [inference]

negative regulation of ectodermal cell fate specification

regulation of ectodermal cell fate specification [inference]

negative regulation of ectodermal cell fate specification

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of Wnt signaling pathway [inference]

regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of phosphorylation [inference]

positive regulation of phosphorylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

regulation of cell-substrate adhesion [inference]

negative regulation of cell-substrate adhesion

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in wound healing

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in wound healing

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of ectodermal cell fate specification

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of muscle cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of striated muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiocyte differentiation [inference]

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in wound healing

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

negative regulation of cell differentiation [inference]

negative regulation of cell fate commitment [inference]

negative regulation of cell fate specification [inference]

negative regulation of ectodermal cell fate specification

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
plasma membrane	ISO	GO_REF
plasma membrane	EXP	PMID PMID
plasma membrane	TAS	Reactome
plasma membrane	IDA	PMID PMID
plasma membrane	IMP	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

recycling endosome membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

recycling endosome membrane

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
G protein-coupled receptor activity
frizzled binding	ISO	GO_REF
phosphatidylinositol-4,5-bisphosphate binding	ISO	GO_REF
Wnt-protein binding	ISO	GO_REF
Wnt-protein binding	IBA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

frizzled binding

Wnt-protein binding

protein domain specific binding [inference]

PDZ domain binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRGPGTAASHSPLGLCALVLALLGALPTDTRAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGAGGSPTAYPTAPYLPDPPFTAMSPSDGRGRLSFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFSPMSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
63	N-linked (GlcNAc...) asparagine			UniProt
164	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Asymmetric localization of PCP proteins	Mus musculus
PCP/CE pathway	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements