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Proto-oncogene tyrosine-protein kinase ROS

Summary

UniProt ID: Q63132
Gene Symbol: Ros1
Gene ID: 25346
Organism: Rattus norvegicus (Norway rat)

External Links

PubChem: Q63132
Re-Glyco: Q63132

Annotation

Keyword: ATP-binding Alternative splicing Cell membrane Glycoprotein Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane helix Tyrosine-protein kinase

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	Reference
regulation of cell growth	ISS	GO_REF
regulation of cell growth	ISO	GO_REF
columnar/cuboidal epithelial cell development	ISS	GO_REF
columnar/cuboidal epithelial cell development	ISO	GO_REF
protein phosphorylation	ISS	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular developmental process [inference]

cell differentiation

cell development [inference]

epithelial cell development [inference]

columnar/cuboidal epithelial cell development

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

columnar/cuboidal epithelial cell development

cellular developmental process [inference]

cell differentiation

cell development [inference]

epithelial cell development [inference]

columnar/cuboidal epithelial cell development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of TOR signaling

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

regulation of localization [inference]

regulation of transport [inference]

regulation of phosphate transport

regulation of growth [inference]

regulation of cell growth

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of TOR signaling

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of TOR signaling

regulation of MAPK cascade [inference]

regulation of ERK1 and ERK2 cascade

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular component organization [inference]

regulation of cell growth

Displaying **all 5** entries
GO Term	Evidence Code	Reference
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF
cell surface	ISO	GO_REF
signaling receptor complex	IBA	GO_REF
perinuclear region of cytoplasm	ISO	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
protein tyrosine kinase activity	ISS	GO_REF
protein tyrosine kinase activity	ISO	GO_REF
protein tyrosine kinase activity	IEA	GO_REF GO_REF
transmembrane receptor protein tyrosine kinase activity	IBA	GO_REF
transmembrane receptor protein tyrosine kinase activity	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKRIRWLTPKPATFVVLGCVWISVAQGTILSSCLTSCVTNLGRQLDSGTRYNLSEACIQGCQFWNSIDQEKCALKCNDTYVTICERESCEVGCSNAEGSYEEEVLDNTELPTAPFASSIGSNGVTLRWNPANISGVKYIIQWKYAQLPGSWAYTETVSKLSYMVEPLHPFTEYIFRVVWIFTAQLHLYSPPSPSYRTHPYGVPETAPFITNIESSSPDTVEVSWAPPYFPGGPILGYNLRLISKTQKLDSGTQRTSFQFYSTLPNTTYRFSIAAVNEVGEGPEAESMITTPSPAVQEEEQWLFLSRKTSLRKRSLKYLVDEAHCLWSDAIRHNITGISVNTQQEVVYFSEGTIIWMKGAANMSDVSDLRIFYRGSALVSSISVDWLYQRMYFIMDNRVHVCDLKHCSNLEEITPFSIVAPQKVVVDSYNGYVFYLLRDGIYRVHLPLPSVRDTKAVRIVESGTLKDFAVKPQSKRIIYFNGTMQVFMSTFLDGSAFHRVLPWVPLADVKSFACENNDFLITDGKAIFQQDSLSFNEFIVGCDLSHIEEFGFGNLVIFGSSVQSYPLPGHPQEVSVLFGSREALIQWKPPILAIGASPSAWQNWTYEVKVSSQDILETTQVFLNISRTVLNVPKLQSSTKYMVSVRASSPKGPGPWSEPSVGTTLVPATEPPFIMAVKEDGLWSKPLSSFGPGEFLSSDVGNVSDMDWYNNSLYYSDTKGNVYVRPLNGMDISENYHISSIAGACALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMAVDPVGGYLYWTTLYSVESTRLNGESSLVLQAQPWLSGKKVIALTLDLSDGLLYWLVQDNQCIHLYTAVLRGWSGADATITEFAAWSTSEISQNALMYYSGRLFWINGFRIITAQEIGQRTSVSVSEPGKFNQFTIIQTSLKPLPGNFSSTPTVIPDSVQESSFRIEGHTSSFRILWNEPPAVDWGIVFYSVEFSAHSKFLAIEQQSLPVFTVEGLEPYALFNLSVTPYTYWGKGQKTSLSFRAPESVPSAPENPRIFILSLGRYTRKNEVVVEFRWNKPKHENGVLTKSEIFYHISKQSGTNKSTEDWVSVSVTPPVMSFQLEAMSPGYIVSFQVRVFTSKGPGPFSDIVMSKTSEIKPCPYLISLLGNKIEFLDMDQNQVVWTFSLEGAVSTVGYTADDEMGYFAQGDALFLLNLHNHSSSKLFQDVLASDIAVIAVDWIARHLYFALKASQDGTQIFDVDLEHKVKSPREVKICKSHTAIISFSMYPLLSRLYWTEVSDLGYQMFYCNISSHTLHHVLQPKASNQHGRRQCSCNVTESELSGAMTVDTSDPDRPWIYFTKQQEIWAMDLEGCQCWKVIMVPATPGKRIISLTVDGEFIYWITTMKDDTEIYQAKKGSGAILSQVKAPRSKHILAYSSALQPFPDKAYLSVASNMVEASILNATNTSLILKLPPVKTNLTWHGITTPTSTYLVYYMEANRANSSDRKHNMLESQENVARIEGLQPFSTYVIQIAVKNYYSDPLEHLSLGKEIQGKTKSGVPGAVCHINATVLSDTSLLVFWTESHKPNGPKELVRYQLVMSYLAPIPETPLRQDEFPSARLSLLVTKLSGGQQYVLKILACHSEEMWCTESHPVSVNMFDTPEKPSALVPENTSLLLDWKAPSNANLTRFWFELQKWKYSEFYHVKASCSQGPVYVCNIANLQPYTPYNIRVVVVYTTGENSSSIPESFKTKAGVPSKPGIPKLLEGSKNSIQWEKAEDNGNRLMYYTLEVRKSISNDSRDQSLRWTAVFNGSCSSICTWRSKNLKGTFQFRAVASNAIGFGEYSEISEDITLVEDGFWITETSFILTIIVGIFLVATVPLTFVWHRSLKNHKATKEGLSVLNDNDQELAELRGLAAGVGLANACYAVHTLPTQEEIESLPAFPREKLSLRLLLGSGAFGEVYEGTAVDILGRGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLSEPQYIILELMEGGDLLSYLRKARGTTLSGPLLTLADLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKHDYYRKRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMFRCWAQEPDQRPTFYNIQDQLQLFRNVSLNNVSHCGQAAPAGGVINKGFEGEDNEMATLNSDDTMPVALMETRNQEGLNYMVLATKCSQSEDRYEGPLGSKESGLHDLKKDERQPADKDFCQQPQVAYGSPGHSEGLNYACLAHSGHGDVSE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	Source
52	N-linked (GlcNAc...) asparagine	UniProt
77	N-linked (GlcNAc...) asparagine	UniProt
333	N-linked (GlcNAc...) asparagine	UniProt
361	N-linked (GlcNAc...) asparagine	UniProt
480	N-linked (GlcNAc...) asparagine	UniProt
623	N-linked (GlcNAc...) asparagine	UniProt
934	N-linked (GlcNAc...) asparagine	UniProt
1010	N-linked (GlcNAc...) asparagine	UniProt
1298	N-linked (GlcNAc...) asparagine	UniProt
1675	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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