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MIRAGE
Advanced glycosylation end product-specific receptor
Summary
- UniProt ID
- Q63495
- Gene Symbol
- Ager Rage
- Gene ID
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
- Cell membrane Cell projection DNA repair DNA replication DNA-binding Disulfide bond Endosome Glycoprotein Immunoglobulin domain Inflammatory response Nucleus Phagocytosis Phosphoprotein RNA-binding Receptor Reference proteome Repeat Signal Transmembrane helix Ubl conjugation
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| response to hypoxia | ||
| microglial cell activation | ||
| microglial cell activation | ||
| regulation of T cell mediated cytotoxicity | ||
| negative regulation of endothelial cell proliferation |
GO Hierarchy
- positive regulation of reactive oxygen species metabolic process
- positive regulation of reactive oxygen species metabolic process
- positive regulation of reactive oxygen species metabolic process
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of signaling [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of signaling [inference]
positive regulation of locomotion [inference]
positive regulation of cellular process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of cell communication [inference]
positive regulation of response to stimulus [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of gene expression
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of gene expression
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of cell adhesion [inference]
regulation of cell population proliferation [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of cell communication [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of cell motility [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| fibrillar center |
|
|
| phagocytic cup | ||
| phagocytic cup | ||
| phagocytic cup | ||
| extracellular region |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| amyloid-beta binding | ||
| DNA binding | ||
| DNA binding | ||
| RNA binding | ||
| RNA binding |
GO Hierarchy
Sequence
MPTGTVARAWVLVLALWGAVAGGQNITARIGEPLMLSCKGAPKKPTQKLEWKLNTGRTEAWKVLSPQGDPWDSVARILPNGSLLLPAIGIVDEGTFRCRATNRLGKEVKSNYRVRVYQIPGKPEIVNPASELTANVPNKVGTCVSEGSYPAGTLSWHLDGKPLIPDGKGTVVKEETRRHPETGLFTLRSELTVTPAQGGTTPTYSCSFSLGLPRRRPLNTAPIQPRVREPLPPEGIQLLVEPEGGTVAPGGTVTLTCAISAQPPPQIHWIKDGTPLPLAPSPVLLLPEVGHEDEGIYSCVATHPSHGPQESPPVNIRVTETGDEGQAAGSVDGSGLGTLALALGILGGLGIAALLIGAILWRKRQPRLEERKAPESQEDEEERAELNQSEEAEMPENGAGGP
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Advanced glycosylation endproduct receptor signaling | Rattus norvegicus |
| TAK1-dependent IKK and NF-kappa-B activation | Rattus norvegicus |
| TRAF6 mediated NF-kB activation | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050855 | renal fibrosis | |
| DOID:12918 | thromboangiitis obliterans | |
| DOID:77 | gastrointestinal system disease | |
| DOID:1875 | impotence | |
| DOID:8947 | diabetic retinopathy | |
| DOID:9352 | type 2 diabetes mellitus | |
| DOID:2841 | asthma | |
| DOID:10652 | Alzheimer's disease |
