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MIRAGE
Sonic hedgehog protein
Summary
- UniProt ID
- Q63673
- Gene Symbol
- Shh Vhh-1
- Gene ID
- 29499
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
- Autocatalytic cleavage Calcium Cell membrane Developmental protein Endoplasmic reticulum Glycoprotein Golgi apparatus Metal-binding Palmitate Protease Reference proteome Signal Transferase Zinc
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | ||
| angiogenesis | ||
| branching involved in blood vessel morphogenesis | ||
| branching involved in blood vessel morphogenesis | ||
| vasculogenesis |
GO Hierarchy
- positive regulation of cell division
- regulation of epithelial cell differentiation
- regulation of epithelial cell differentiation
- positive regulation of cell division
biological process
cellular process [inference]
multicellular organismal process [inference]
developmental process [inference]
anatomical structure morphogenesis [inference]
anatomical structure development [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
negative regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of lymphocyte proliferation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
regulation of hemopoiesis [inference]
regulation of signaling [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of cellular process [inference]
positive regulation of cell population proliferation
positive regulation of cell differentiation [inference]
positive regulation of cell adhesion [inference]
positive regulation of cell activation [inference]
positive regulation of developmental process [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
negative regulation of immune system process [inference]
negative regulation of cellular process [inference]
negative regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of neuron differentiation [inference]
regulation of muscle cell differentiation [inference]
regulation of cell development [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of cell adhesion [inference]
regulation of cell population proliferation
regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of neuron differentiation [inference]
regulation of muscle cell differentiation [inference]
regulation of cell development [inference]
positive regulation of cellular process [inference]
positive regulation of cell population proliferation
positive regulation of cell differentiation [inference]
positive regulation of cell adhesion [inference]
positive regulation of cell activation [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of lymphocyte proliferation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
positive regulation of cell activation [inference]
regulation of cellular localization [inference]
regulation of multicellular organismal process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of lymphocyte proliferation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
positive regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
| GO Term | Evidence Code | Reference |
|---|---|---|
| Golgi membrane | ||
| Golgi membrane | ||
| extracellular region | ||
| extracellular region | ||
| extracellular region |
| GO Term | Evidence Code | Reference |
|---|---|---|
| patched binding | ||
| patched binding | ||
| patched binding | ||
| calcium ion binding | ||
| calcium ion binding |
GO Hierarchy
Sequence
MLLLLARCFLVALASSLLVCPGLACGPGRGFGKRQHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKARIHCSVKAENSVAAKSDGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDEGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSGPTPGPSPLFASRVRPGQRVYVVAERGGDRRLLPAAVHSVTLREEAAGAYAPLTADGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDGGGGGSIPAPQSVAEARGAGPPAGIHWYSQLLYHIGTWLLDSETLHPLGMAVKSS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 279 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Hedgehog ligand biogenesis | Rattus norvegicus |
| Ligand-receptor interactions | Rattus norvegicus |
| Release of Hh-Np from the secreting cell | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080855 | Parkinsonism | |
| DOID:5844 | myocardial infarction |
