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Trifunctional enzyme subunit alpha, mitochondrial

Summary

UniProt ID: Q64428
Gene Symbol: Hadha
Gene ID: 170670
Organism: Rattus norvegicus (Norway rat)

External Links

GlyGen: Q64428
PubChem: Q64428
The O-GlcNAc Database: Q64428
RaftProt: Q64428
O-GlcNAcAtlas: Q64428
Re-Glyco: Q64428

Annotation

Keyword: Acetylation Fatty acid metabolism Lyase Methylation Mitochondrion inner membrane Multifunctional enzyme NAD Oxidoreductase Phosphoprotein Reference proteome Transferase Transit peptide

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
fatty acid beta-oxidation	ISO	GO_REF
fatty acid beta-oxidation	IDA	PMID
fatty acid beta-oxidation	IBA	GO_REF
fatty acid beta-oxidation	IEA	GO_REF GO_REF GO_REF
response to xenobiotic stimulus	IDA	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

catabolic process [inference]

lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

primary metabolic process [inference]

lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid oxidation [inference]

fatty acid beta-oxidation

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

cardiolipin metabolic process [inference]

cardiolipin acyl-chain remodeling

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid oxidation [inference]

fatty acid beta-oxidation

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to xenobiotic stimulus

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to nitrogen compound [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide hormone [inference]

response to insulin

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
mitochondrion	ISS	GO_REF
mitochondrion	ISO	GO_REF
mitochondrion	IEA	GO_REF GO_REF
mitochondrial inner membrane	ISS	GO_REF
mitochondrial inner membrane	ISO	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

mitochondrial protein-containing complex [inference]

mitochondrial fatty acid beta-oxidation multienzyme complex

catalytic complex [inference]

oxidoreductase complex [inference]

fatty acid beta-oxidation multienzyme complex [inference]

mitochondrial fatty acid beta-oxidation multienzyme complex

transferase complex [inference]

fatty acid beta-oxidation multienzyme complex [inference]

mitochondrial fatty acid beta-oxidation multienzyme complex

cellular anatomical structure [inference]

nucleoid [inference]

mitochondrial nucleoid

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

membraneless organelle [inference]

intracellular membraneless organelle [inference]

mitochondrial nucleoid

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular membraneless organelle [inference]

mitochondrial nucleoid

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	Reference
fatty-acyl-CoA binding	IDA	PMID
(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity	IDA	PMID
(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity	IMP	PMID
(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity	IEA	GO_REF GO_REF
acetyl-CoA C-acyltransferase activity	IDA	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity

long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

C-acyltransferase activity [inference]

acetyl-CoA C-acyltransferase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

thiolester hydrolase activity [inference]

acyl-CoA hydrolase activity [inference]

fatty acyl-CoA hydrolase activity [inference]

long-chain fatty acyl-CoA hydrolase activity

lyase activity [inference]

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

enoyl-CoA hydratase activity

3-hydroxyacyl-CoA dehydratase activity

deacylase activity [inference]

acyl-CoA hydrolase activity [inference]

fatty acyl-CoA hydrolase activity [inference]

long-chain fatty acyl-CoA hydrolase activity

binding [inference]

lipid binding [inference]

fatty acid derivative binding [inference]

fatty-acyl-CoA binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

NAD+ binding

acyl-CoA binding [inference]

fatty-acyl-CoA binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

NAD+ binding

acyl-CoA binding [inference]

fatty-acyl-CoA binding

protein-containing complex binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

NAD+ binding

acyl-CoA binding [inference]

fatty-acyl-CoA binding

sulfur compound binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MVASRAIGSLSRFSAFRILRSRGCICHSFTTSSALLSRTHINYGVKGDVAVIRINSPNSKVNTLNKEVQSEFVEVMNEIWANDQIRSAVLISSKPGCFVAGADINMLASCTTPQEAARISQEGQKMFEKLEKSPKPVVAAISGSCLGGGLELAIACQYRIATKDRKTVLGVPEVLLGILPGAGGTQRLPKMVGVPAAFDMMLTGRNIRADRAKKMGLVDQLVDPLGPGIKSPEERTIEYLEEVAVNFAKGLADRKVSAKQSKGLMEKLTSYAMTIPFVRQQVYKTVEEKVKKQTKGLYPAPLKIIDAVKTGLEQGNDAGYLAESEKFGELALTKESKALMGLYNGQVLCKKNKFGAPQKTVQQLAILGAGLMGAGIAQVSVDKGLKTLLKDTTVTGLGRGQQQVFKGLNDKVKKKALTSFERDSIFSNLIGQLDYKGFEKADMVIEAVFEDLAVKHKVLKEVESVTPEHCIFASNTSALPINQIAAVSQRPEKVIGMHYFSPVDKMQLLEIITTDKTSKDTTASAVAVGLKQGKVIIVVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDALTTGFGFPVGAATLADEVGIDVAQHVAEDLGKAFGERFGGGSVELLKLMVSKGFLGRKSGKGFYIYQSGSKNKNLNSEIDNILVNLRLPAKPEVSSDEDIQYRVITRFVNEAVLCLQEGILATPEEGDIGAVFGLGFPPCLGGPFRFVDLYGAQKVVDRLRKYESAYGTQFTPCQLLRDLANNSSKKFYQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	PubMed ID	GlyTouCan ID	Source
185	26446791 27213235 34502162 38843836	G49108TO	GlyGen The O-GlcNAc Database
269	26446791 27213235 34502162 38843836	G49108TO	GlyGen The O-GlcNAc Database
270	26446791 27213235 34502162 38843836	G49108TO	GlyGen The O-GlcNAc Database
521	26446791 27213235 34502162 38843836	G49108TO	The O-GlcNAc Database
524	26446791 27213235 34502162 38843836	G49108TO	GlyGen The O-GlcNAc Database
615	26446791 27213235 34502162 38843836	G49108TO	GlyGen The O-GlcNAc Database
668	26446791 27213235 34502162 38843836	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
Acyl chain remodeling of CL	Rattus norvegicus
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	Rattus norvegicus
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	Rattus norvegicus
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	Rattus norvegicus
Beta oxidation of myristoyl-CoA to lauroyl-CoA	Rattus norvegicus
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	Rattus norvegicus
Beta oxidation of palmitoyl-CoA to myristoyl-CoA	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

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