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Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

Summary

UniProt ID: Q64518
Gene Symbol: Atp2a3
Gene ID: 53313
Organism: Mus musculus (house mouse)

External Links

PubChem: Q64518
The O-GlcNAc Database: Q64518
RaftProt: Q64518
Re-Glyco: Q64518

Annotation

Keyword: ATP-binding Acetylation Alternative splicing Calcium transport Endoplasmic reticulum Magnesium Metal-binding Phosphoprotein Reference proteome Sarcoplasmic reticulum Translocase Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
intracellular calcium ion homeostasis	ISO	GO_REF
intracellular calcium ion homeostasis	IBA	GO_REF
intracellular calcium ion homeostasis	IEA	GO_REF
endoplasmic reticulum calcium ion homeostasis	ISO	GO_REF
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

intercellular transport [inference]

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

cellular localization [inference]

intracellular transport [inference]

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

endoplasmic reticulum calcium ion homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

intercellular transport [inference]

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

intracellular transport [inference]

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transport from cytosol to endoplasmic reticulum

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

establishment of localization in cell [inference]

intracellular transport [inference]

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

cellular localization [inference]

intracellular transport [inference]

cytosol to endoplasmic reticulum transport [inference]

calcium ion transport from cytosol to endoplasmic reticulum

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
endoplasmic reticulum	ISO	GO_REF
endoplasmic reticulum	IDA	PMID
endoplasmic reticulum	IEA	GO_REF
membrane	IEA	GO_REF
sarcoplasmic reticulum	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane

endoplasmic reticulum membrane [inference]

sarcoplasmic reticulum membrane

bounding membrane of organelle [inference]

sarcoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

sarcoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

sarcoplasmic reticulum

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	Reference
calcium channel regulator activity	ISO	GO_REF
calcium channel regulator activity	IEA	GO_REF
P-type calcium transporter activity	ISS	GO_REF
P-type calcium transporter activity	ISO	GO_REF GO_REF
P-type calcium transporter activity	IEA	GO_REF GO_REF GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type calcium transporter activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity

P-type calcium transporter activity

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type calcium transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type calcium transporter activity

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type calcium transporter activity

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

P-type calcium transporter activity

binding [inference]

protein binding [inference]

transmembrane transporter binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

peptidase activator activity involved in apoptotic process [inference]

cysteine-type endopeptidase activator activity involved in apoptotic process

cysteine-type endopeptidase regulator activity involved in apoptotic process [inference]

cysteine-type endopeptidase activator activity involved in apoptotic process

peptidase regulator activity [inference]

peptidase activator activity [inference]

peptidase activator activity involved in apoptotic process [inference]

cysteine-type endopeptidase activator activity involved in apoptotic process

molecular function activator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

peptidase activator activity involved in apoptotic process [inference]

cysteine-type endopeptidase activator activity involved in apoptotic process

transporter regulator activity [inference]

channel regulator activity [inference]

ion channel regulator activity [inference]

calcium channel regulator activity

ATP-dependent activity [inference]

calcium-dependent ATPase activity

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type calcium transporter activity

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

P-type calcium transporter activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MEEAHLLSAADVLRRFSVTAEGGLSLEQVTDARERYGPNELPTEEGKSLWELVVEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTDAIPDPRAVNQDKKNMLFSGTNIASGKALGVAVATGLQTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEAEAGTCRLHEFTISGTTYTPEGEVRQGEQPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLKGLSRVERAGACNSVIKQLMRKEFTLEFSRDRKSMSVYCTPTRADPKVQGSKMFVKGAPESVIERCSSVRVGSRTAPLSTTSREHILAKIRDWGSGSDTLRCLALATRDTPPRKEDMHLDDCSRFVQYETDLTFVGCVGMLDPPRPEVAACITRCSRAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVLGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRNPREALISGWLFFRYLAIGVYVGLATVAAATWWFLYDTEGPQVTFYQLRNFLKCSEDNPLFAGIDCKVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWLNPWLLGAVVMSMALHFLILLVPPLPLIFQVTPLSGRQWGVVLQMSLPVILLDEALKYLSRNHMDEKKDLK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites