GlyCosmos Portal

Submissions

Vinculin

Summary

UniProt ID: Q64727
Gene Symbol: Vcl
Gene ID: 22330
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q64727
PubChem: Q64727
RaftProt: Q64727
Re-Glyco: Q64727

Annotation

Keyword: 3D-structure Acetylation Actin-binding Cell adhesion Cell junction Cell membrane Cell projection Cytoskeleton Direct protein sequencing Palmitate Phosphoprotein Reference proteome Repeat

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	Reference
morphogenesis of an epithelium	ISO	GO_REF
cell adhesion	IDA	PMID
cell adhesion	IBA	GO_REF
cell adhesion	IEA	GO_REF
lamellipodium assembly	IDA	PMID

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion [inference]

epithelial cell-cell adhesion

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell junction assembly [inference]

cell-cell junction assembly [inference]

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

plasma membrane bounded cell projection organization [inference]

lamellipodium organization [inference]

lamellipodium assembly

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

adherens junction organization [inference]

adherens junction assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

tissue morphogenesis [inference]

morphogenesis of an epithelium

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to cell surface

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of protein localization to cell-cell junction [inference]

regulation of protein localization to adherens junction

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

regulation of endothelial cell development [inference]

regulation of establishment of endothelial barrier

regulation of cell development [inference]

regulation of endothelial cell development [inference]

regulation of establishment of endothelial barrier

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

regulation of endothelial cell development [inference]

regulation of establishment of endothelial barrier

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

regulation of focal adhesion assembly

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

regulation of endothelial cell development [inference]

regulation of establishment of endothelial barrier

regulation of cell development [inference]

regulation of endothelial cell development [inference]

regulation of establishment of endothelial barrier

regulation of cellular component organization [inference]

regulation of cell-substrate junction organization [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

regulation of cell junction assembly [inference]

regulation of cell-substrate junction assembly [inference]

regulation of focal adhesion assembly

regulation of cell motility [inference]

regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

regulation of endothelial cell differentiation [inference]

regulation of endothelial cell development [inference]

regulation of establishment of endothelial barrier

Displaying entries **1 - 5** of 44 in total

1

2

3

4

5

…

Next ›

Last »
GO Term	Evidence Code	Reference
stress fiber	ISO	GO_REF
podosome	IDA	PMID
podosome	IEA	GO_REF
cytoplasm	IDA	PMID
cytoplasm	IBA	GO_REF

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

plasma membrane

sarcolemma

membrane microdomain [inference]

membrane raft

Z disc

cell junction [inference]

anchoring junction [inference]

cell-cell junction

adherens junction

zonula adherens

fascia adherens

cell-cell contact zone

intercalated disc

cell-substrate junction [inference]

focal adhesion

actin filament bundle [inference]

contractile actin filament bundle [inference]

stress fiber

actomyosin [inference]

stress fiber

costamere

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

podosome

cytoskeleton

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton [inference]

terminal web

intracellular organelle [inference]

intracellular membraneless organelle [inference]

podosome

cytoskeleton

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton [inference]

terminal web

cluster of actin-based cell projections [inference]

brush border

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

Displaying entries **1 - 5** of 11 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	Reference
dystroglycan binding	ISO	GO_REF
actin binding	ISO	GO_REF
actin binding	IEA	GO_REF
structural molecule activity	IEA	GO_REF
beta-catenin binding	IBA	GO_REF

GO Hierarchy

molecular function

structural molecule activity

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

actin binding

actin filament binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

GTPase binding [inference]

small GTPase binding

alpha-catenin binding

protein-containing complex binding [inference]

actin filament binding

molecular adaptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPNASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGASPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEIAALTSKLGDLRRQGKGDSPEARALAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKAQMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGRLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVISAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMMAARQLHDEARKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	GlyTouCan ID	Source
288	G62765YT	GlyGen
635	G62765YT	GlyGen
807	G80920RR	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 8** entries
Pathway Name	Organism
Activation of STAT3 by cadherin engagement	Mus musculus
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Mus musculus
MAP2K and MAPK activation	Mus musculus
Neutrophil degranulation	Mus musculus
Platelet degranulation	Mus musculus
Regulation of CDH1 Function	Mus musculus
Smooth Muscle Contraction	Mus musculus
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements