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Xylosyl- and glucuronyltransferase LARGE1

Summary

UniProt ID: Q66PG2
Gene Symbol: large large1
Gene ID: 446213
Organism: Danio rerio (zebrafish)

External Links

PubChem: Q66PG2
Re-Glyco: Q66PG2

Annotation

Keyword: Coiled coil Glycoprotein Glycosyltransferase Golgi apparatus Manganese Metal-binding Multifunctional enzyme Reference proteome Signal-anchor Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
glycoprotein biosynthetic process	ISS	GO_REF
protein O-linked glycosylation via mannose	ISS	GO_REF
protein O-linked glycosylation via mannose	IBA	GO_REF
protein O-linked glycosylation via mannose	IEA	GO_REF
skeletal muscle tissue regeneration	ISS	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via mannose

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

tissue regeneration [inference]

skeletal muscle tissue regeneration

animal organ development [inference]

muscle organ development [inference]

skeletal muscle organ development

muscle structure development [inference]

muscle organ development [inference]

skeletal muscle organ development

growth [inference]

developmental growth [inference]

tissue regeneration [inference]

skeletal muscle tissue regeneration

Displaying **all 4** entries
GO Term	Evidence Code	Reference
Golgi membrane	ISS	GO_REF
Golgi membrane	IEA	GO_REF
Golgi apparatus	ISS	PMID GO_REF
Golgi apparatus	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
glucuronosyltransferase activity	ISS	GO_REF
glucuronosyltransferase activity	IBA	GO_REF
hexosyltransferase activity	ISS	GO_REF
manganese ion binding	ISS	GO_REF
xylosyltransferase activity	ISS	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

glucuronosyltransferase activity

hexosyltransferase activity

glucuronosyltransferase activity

pentosyltransferase activity [inference]

xylosyltransferase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MLGMCRGRRKFVAASLALIFIPALTWLYLSSANITVKPLPLSPLDPQSSAVVGAAAEHQSLELRLRDVEEHNNALRREISRTPRVPTHSSHPSSSRHGNQLHTHSTEEGTGDSEAKKGAAAGNSSDCVPQPVVKKCETIHIAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHIITDSIARKILADLFHTWMVPAVHVNFYDADELKSEVSWIPNKHYSGIHGLMKLVLTKTLPSDLEKVIVLDTDITFATDIAELWVVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGFNTGVILLLLDRLRKLKWEQMWRLTAERELMSMLSTSLADQDIFNAVIKQNPFLVHQLPCYWNVQLSDHTRSEKCYKDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSETDHNSENLQKTLSELDEDDPCYEFRRERFTVHRTHVYFLHYEYEPTVDNTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRSNVGYHIVYKEGQFYPVNLLRNVAMGQVNTPYMFLSDIDFLPMYGLYEYLRKSVVQLDMGNTKKALVVPAFETLRYRLSFPKSKAELLSQLDMGTLFTFRYHVWTKGHAPTDFAKWRTATTPYRVQWEADFEPYVMVRRESPEYDRRFVGFGWNKVAHIMELDAQEYEFVVLPNAYMIHMPHAPSFDITKFRSNKQYRACLKTLKEEFQQNMSRRYGFAALKYMTVDNNS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
123	N-linked (GlcNAc...) asparagine	UniProt
149	N-linked (GlcNAc...) asparagine	UniProt
273	N-linked (GlcNAc...) asparagine	UniProt
738	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Matriglycan biosynthesis on DAG1	Danio rerio

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

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External Links

Annotation

International Collaboration

Acknowledgements