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MIRAGE

3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2

Summary

UniProt ID: Q67ZE1
Gene Symbol: 3BETAHSD/D2 At2g26260 RTNLB19 T1D16.10
Gene ID: 817166
Organism: Arabidopsis thaliana (thale cress)

External Links

PubChem: Q67ZE1
Re-Glyco: Q67ZE1

Annotation

Keyword: Alternative splicing Endoplasmic reticulum Glycoprotein NAD Oxidoreductase Reference proteome Sterol biosynthesis Transmembrane helix

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	Reference
sterol biosynthetic process
auxin transport	IMP	PMID
plant organ development	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

sterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

developmental process [inference]

anatomical structure development [inference]

plant organ development

plant gross anatomical part developmental process [inference]

plant organ development

localization [inference]

establishment of localization [inference]

transport [inference]

hormone transport [inference]

auxin transport

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

auxin transport

Displaying **all 4** entries
GO Term	Evidence Code	Reference
endoplasmic reticulum	IDA	PMID
endoplasmic reticulum membrane	ISS	GO_REF
endoplasmic reticulum membrane	IEA	GO_REF
membrane	IDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 4** entries
GO Term	Evidence Code	Reference
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA	GO_REF
3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity	IDA	PMID
3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity	IGI	PMID
3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity [inference]

3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity [inference]

3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSPAATETERWCVVTGGRGFAARHLVEMLVRYEMFCVRIADLAPAIMLDPQEGNGVLDEGLRSGRVQYISADLRDKSQVVKAFQGAEVVFHMAAPDSSINNHQLQYSVNVQGTQNVIDACVDVGVKRLIYTSSPSVVFDGVHGILNGTESMAYPIKHNDSYSATKAEGEELIMKANGRNGLLTCCIRPSSIFGPGDRLLVPSLVAAARAGKSKFIIGDGNNLYDFTYVENVAHAHVCAERALASGGDVSTKAAGQAYFITNMEPIKFWEFMSQLLDGLGYERPSIKIPAFIMMPIAHLVELTYKVLGPYGMTVPQLTPSRVRLLSCSRTFDSTKAKDRLGYAPVVPLQEGIRRTIDSFSHLTAGSQSKREGPSKASRILGGGKVADTLLWKDLKQTLIAIFILISIYYNFVATGSTVVTALSKALLVASVFLFLHGILPEKIFGYTVEKIPASQFHLSKDSSHDLSLSVISSWNTTVKALRSLCQGNDWSFFFKVVFVLLALSLAGAISLHSIFVIGLPIAFLAFLVYEKKEQEIDSIVVSFKSFACKHKSDVYEKLFGSKKHD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
146	N-linked (GlcNAc...) asparagine			UniProt
158	N-linked (GlcNAc...) asparagine			UniProt
474	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026