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Tyrosine-protein kinase-like otk

Summary

UniProt ID: Q6AWJ9
Gene Symbol: CG8967 otk
Gene ID: 36283
Organism: Drosophila melanogaster (fruit fly)

External Links

GlyGen: Q6AWJ9
Re-Glyco: Q6AWJ9

Annotation

Keyword: 3D-structure Cell adhesion Cell membrane Disulfide bond Glycoprotein Immunoglobulin domain Neurogenesis Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
cell adhesion	IDA	PMID
homophilic cell-cell adhesion	IBA	GO_REF
axon guidance	IMP	PMID PMID
axon guidance	IGI	PMID
axon guidance	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion [inference]

homophilic cell-cell adhesion

cell recognition [inference]

neuron recognition [inference]

dendrite self-avoidance

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

reproductive process [inference]

developmental process involved in reproduction [inference]

genitalia morphogenesis [inference]

post-embryonic genitalia morphogenesis [inference]

imaginal disc-derived genitalia morphogenesis [inference]

internal genitalia morphogenesis

female genitalia morphogenesis [inference]

imaginal disc-derived female genitalia morphogenesis

male genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

genitalia morphogenesis [inference]

post-embryonic genitalia morphogenesis [inference]

imaginal disc-derived genitalia morphogenesis [inference]

internal genitalia morphogenesis

female genitalia morphogenesis [inference]

imaginal disc-derived female genitalia morphogenesis

male genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

genitalia morphogenesis [inference]

post-embryonic genitalia morphogenesis [inference]

imaginal disc-derived genitalia morphogenesis [inference]

internal genitalia morphogenesis

female genitalia morphogenesis [inference]

imaginal disc-derived female genitalia morphogenesis

male genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

male anatomical structure morphogenesis [inference]

male genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
plasma membrane	IDA	PMID PMID
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF
plasma membrane	HDA	PMID
membrane	ISM	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
transmembrane receptor protein tyrosine kinase activity	IDA	PMID
transmembrane receptor protein tyrosine kinase activity	IEA	GO_REF
transmembrane signaling receptor activity	IGI	PMID
ATP binding	IEA	GO_REF
Wnt-protein binding	IPI	PMID PMID

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

semaphorin receptor binding

Wnt-protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

cell adhesion molecule binding

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MTARMISICGLVMALMMASVLASSSRFQRVPQSQSVVENESVKFECESTDSYSELHYDWLHNGHRIAYDKRVHQIGSNLHIEAVRRTEDVGNYVCIATNLASGAREASPPAKLSVIYLESASVQLLGSNRNELLLKCHVEGASGDLEPLEIEWYRNSEKLSTWKNVQLDQHRLIIRQPGSEDDGLYRCTASNAAGRVMSKQGYVYQSSVKCLPRLPRRKNEKMMESWDKQTFLCRGKRGGAAGLEALPAAPEDLRIVQGPIGQSIIKEGEPTALTCLYELPDELKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKFVPQPTSKNLELDAVVAKVHCKAQGTPTPQVQWVRDGENTTLPDHVEVDANGTLIFRNVNSEHRGNYTCLATNSQGQINATVAINVVVTPKFSVPPVGPIETSEQGTVVMHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCTIGNSAGLKREDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLNDLSTKEAGGDQPDVAGNGKGSEQEPCLSKQHNGHSKSRSKSSGDAQKSDDTACSQQSRASKKSAHIYEQLALPRSGLSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKVNTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYSREYHKHRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQVVQRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAALSKAMQSAEK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	PubMed ID	Source
39	N-linked (GlcNAc...) asparagine		UniProt GlyGen
336	N-linked (GlcNAc...) asparagine		UniProt GlyGen
417	N-linked (GlcNAc...) asparagine		UniProt GlyGen
429	N-linked (GlcNAc...) asparagine		UniProt GlyGen
444	N-linked (GlcNAc...) asparagine		UniProt GlyGen
457	N-linked (GlcNAc...) asparagine		UniProt GlyGen
512	N-linked (GlcNAc...) asparagine		UniProt GlyGen
524	N-linked (GlcNAc...) asparagine	19349973	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Aspirin ADME	Drosophila melanogaster
Basigin interactions	Drosophila melanogaster
Degradation of the extracellular matrix	Drosophila melanogaster
Integrin cell surface interactions	Drosophila melanogaster
Proton-coupled monocarboxylate transport	Drosophila melanogaster
Regulation of commissural axon pathfinding by SLIT and ROBO	Drosophila melanogaster

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

International Collaboration

Acknowledgements