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Pleiotropic ABC efflux transporter of multiple drugs CDR1

Summary

UniProt ID: Q6FK23
Gene Symbol: CDR1 CAGL0M01760g
Gene ID: 2891191
Organism: Nakaseomyces glabratus CBS 138

External Links

Re-Glyco: Q6FK23

Annotation

Keyword: ATP-binding Cell membrane Glycoprotein Phosphoprotein Reference proteome Repeat Transmembrane helix Transport

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	Reference
intracellular monoatomic cation homeostasis	IEA	GO_REF
azole transmembrane transport	IMP	PMID
cellular response to xenobiotic stimulus	IMP	PMID PMID
xenobiotic detoxification by transmembrane export across the plasma membrane	ISA	PMID
xenobiotic detoxification by transmembrane export across the plasma membrane	IEA	GO_REF GO_REF

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

transmembrane transport [inference]

azole transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis

response to stimulus [inference]

response to chemical [inference]

response to xenobiotic stimulus [inference]

cellular response to xenobiotic stimulus

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

xenobiotic transport [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

transmembrane transport [inference]

azole transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

nitrogen compound transport [inference]

azole transmembrane transport

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	Reference
vacuolar lumen	IDA	PMID
plasma membrane	EXP	PMID PMID
plasma membrane	IDA	PMID
plasma membrane	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
ATP binding	IEA	GO_REF
ABC-type xenobiotic transporter activity	IDA	PMID
ABC-type xenobiotic transporter activity	IEA	GO_REF GO_REF
ATP hydrolysis activity	IDA	PMID
ATP hydrolysis activity	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

xenobiotic transmembrane transporter activity [inference]

ABC-type xenobiotic transporter activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSLASDKKDADVASTTTTAQDDDNLSTYHGFDHHVQDQVRQLARTLTQQSSLHQKKEHTLPEEGINPIFTNTEADDYNPRLDPTSDEFSSAEWVQNMSNISNSDPDYYKPYSLGCYWKDLVATGESADIEYQANFLNGPYKGLKTVYNTVVPSTASSKDKNFKILKSMEGAVNPGELLVVLGRPGSGCTTLLKSISSNTHGFNIAKESTISYSGMTPNDIRKHFRGEVVYNAEADIHLPHLTVYQTLLTVARLKTPQNRLKGIDRETYARHLTEVAMATFGLSHTRNTKVGNDLVRGVSGGERKRVSIAEVSICGSKFQCWDNATRGLDSATALEFIRALKVQASISNAAATVAIYQCSQDAYDLFDKVCVLYDGYQIYFGPAGKAKEYFQKMGYVSPERQTTADFLTAVTSPSERIINQDYINRGIFVPQTPKEMWEYWRASEDHADLIKEIDSKLSDNYDANLAEIKDAHVARQSKRARPSSPYTVSYGMQIKYLLIRNFWRIKQSSGVTLFMVIGNSSMAFILGSMFYKVMKHNTTSTFYFRGAAMFFAVLFNAFSSLLEIFSLFEARPITEKHRTYSLYHPSADAFASILSEVPAKLITAVCFNIIYYFLVNFRRNGGVFFFYFLINIVAVFAMSHLFRCVGSVSKTLSAAMVPASMLLLGLSMYSGFAIPRTKILGWSKWIWYINPLAYLFESLMINEFHDRKFPCSQYIPSGSVYNNVPADSRICSSVGAIRGNDYVLGDDFLRESYSYLHKHKWRGFGIGLAYVIFFLVLYLILCEYNEGAKQKGEILVFPQNIVRRMKKERKLKNVSSDNDVEIGDVSDISDKKILADSSDESEESGANIGLSQSEAIFHWRNLCYDVQIKKETRRILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGVITGEVSVDGKQRDDSFARSIGYCQQQDLHLKTSTVRESLRFSAYLRQPADVSIEEKNQYVEDVIKILEMEQYADAVVGVPGEGLNVEQRKRLTIGVELAAKPKLLVFLDEPTSGLDSQTAWSICQLMKKLANHGQAILCTIHQPSAILMQEFDRLLFLQRGGKTVYFGDLGDGCKTMIDYFESHGSHKCPPDANPAEWMLEVVGAAPGSHANQDYHEVWRNSDEYQKVQEELEWMSNELPKKNTNNSETVHKEFATGVLYQCKLVSLRLFQQYWRSPDYLWSKFFLTIFNNIFIGFTFFKADRSLQGLQNQMLAVFMFTVIFNPLLQQYLPSFVQQRDLYEARERPSRTFSWKAFIVSQILVEIPWNILAGTVAFVIYYYAIGFYSNASVAHQLHERGALFWLFSCAFYVYIGSLALFCISFNQVAEAAANMASLMFTLSLSFCGVLVTPNGMPRFWIFMYRVSPLTYLIDGMLSTGVANVAIKCSNYELLRFSPAANLTCGEYLGPYLQTVKTGYIVDPSATDTCELCPYSHTNDFLSSVSSKYSRRWRNWGIFICYIAFNYIAGIFLYWLARVPKKSGKLAKK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 9** entries
Position	Description	Source
24	N-linked (GlcNAc...) asparagine	UniProt
96	N-linked (GlcNAc...) asparagine	UniProt
99	N-linked (GlcNAc...) asparagine	UniProt
323	N-linked (GlcNAc...) asparagine	UniProt
537	N-linked (GlcNAc...) asparagine	UniProt
813	N-linked (GlcNAc...) asparagine	UniProt
1159	N-linked (GlcNAc...) asparagine	UniProt
1301	N-linked (GlcNAc...) asparagine	UniProt
1412	N-linked (GlcNAc...) asparagine	UniProt