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Alpha-2-macroglobulin-P

Summary

UniProt ID: Q6GQT1
Gene Symbol: A2m A2mp
Gene ID: 232345
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0005723
GlyGen: Q6GQT1
PubChem: Q6GQT1
The O-GlcNAc Database: Q6GQT1
O-GlcNAcAtlas: Q6GQT1
Re-Glyco: Q6GQT1

Annotation

Keyword: Bait region Disulfide bond Glycoprotein Pregnancy Reference proteome Secreted Serine protease inhibitor Signal Thioester bond

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	Reference
negative regulation of complement activation, lectin pathway	ISO	GO_REF
negative regulation of complement activation, lectin pathway	IEA	GO_REF
female pregnancy
stem cell differentiation	IDA	PMID

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

stem cell differentiation

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

multi-multicellular organism process [inference]

female pregnancy

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

stem cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of complement activation [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of complement activation [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of complement activation [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

Displaying 1 entry
GO Term	Evidence Code	Reference
obsolete extracellular space

GO Hierarchy

cellular component

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	Reference
protease binding	ISO	GO_REF
protease binding	IBA	GO_REF
protease binding	IEA	GO_REF
endopeptidase inhibitor activity	ISO	GO_REF GO_REF
endopeptidase inhibitor activity	IBA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding

growth factor binding

interleukin-1 binding

neurotrophin binding [inference]

enzyme binding

protease binding

cytokine binding [inference]

chemokine binding [inference]

C-X-C chemokine binding [inference]

interleukin-8 binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGKRWLPSLALLPLPPPLLLLLLLLLPTNASAPQKPIYMVMVPSLLHAGTPEKGCLLFNHLNETVTVKVSMESVRGNQSLFTDLVVDKDLFHCASFIVPQSSSNEVMFLTVQVKGPTHEFRRRSTVLIKTKESLVFAQTDKPIYKPGQMVRFRVVSLDENFHPLNELIPLLYIQDSKKNRIAQWQNFRLEGGLKQLSFPLSSEPTQGSYKVVIRTESGRTVEHPFSVKEFVLPKFEVKVAVPETITILEEEMNVSVCGIYTYGKPVPGHVTVNICRKYSNPSSCFGEESLAFCEKFSQQLDGRGCFSQLVKTKSFQLKRQEYEMQLDVNAKIQEEGTGVEETGKGLTKITRTITKLSFVNVDTHFRQGIPFVGQVLLVDGRGTPIPYEMIFIGADEANQNINTTTDKNGLARFSINTDDIMGTSLTVRAKYKDSNVCYGFRWLTEENVEAWHTANAVFSPSRSFVHLESLPYKLRCEQTLAVQAHYILNDEAVLERKELVFYYLMMAKGGIVRAGTHVLPVTQGHKKGHFSILISMETDLAPVARLVLYTILPNGEVVGDTVKYEIEKCLANKVDLVFHPNIGLPATRAFLSVMASPQSLCGLRAVDQSVLLTKPEAELSASLVYDLLPVKDLTGFPKGVNQQEEDTNGCLKQNDTYINGILYSPVQNTNEEDMYGFLKDMGLKVFTNLNIRKPKVCERLGVNKIPAAYHLVSQGHMDAFLESSESPTETTRSYFPETWIWDLVIVDSTGVAEMEVTVPDTITEWKAGAFCLSNDTGLGLSPVIDFQAFQPFFVDLTMPYSVIRGEAFTLKATVLNYLQTCIRVGVQLEASPDFLATPEEKEQKSHCICMNERHTMSWAVIPKSLGNVNFTVSAEALDSKELCRNEVPVVPERGKKDTIIKSLLVEPEGLENEVTFNSLLCPTGAEVSEQISLKLPSDVVEESARASVTVLGDILGSAMQNTQDLLKMPYGCGEQNMVLFAPNIYVLDYLNETEQLTQEIKTKAITYLNTGYQRQLNYKHRDGSYSTFGDKPGRSHANTWLTAFVLKSFAQARRYIFIDESHITQALTWLSQQQKDNGCFRSSGSLLNNAMKGGVEDEVTLSAYITIALLEMSLPVTHPVVRNALFCLDTAWKSARRGASGNHVYTKALLAYAFALAGNQDTKKEILKSLDEEAVKEDNSVHWTRAQKPRVPADLWYQPQAPSAEVEMTAYVLLAYLTTELVPTREDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVALHALSKYGAATFTRAKKAAHVTIQSSGAFYTKFQVNNDNQLLLQRVTLPTVPGDYTAKVAGEGCVYLQTSLKYSVLPREKEFPFALVVQTLPGTCEDLKAHTTFQISLNISYIGSRSDSNMAIADVKMVSGFIPLKPTVKMLERSVHVSRTEVSNNHVLIYLDKVSNQMLTLFFMVQQDIPVRDLKPAIVKVYDYYEKDEFAVAKYSAPCSAGYGNA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 12 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
62	N-linked (GlcNAc...) asparagine		G80920RR	GlycoProtDB UniProt GlyGen
77	N-linked (GlcNAc...) asparagine		G80920RR	UniProt GlyGen
253	N-linked (GlcNAc...) asparagine			UniProt GlyGen
402	N-linked (GlcNAc...) asparagine			UniProt GlyGen
599			G49108TO	GlyGen
654	N-linked (GlcNAc...) asparagine			UniProt GlyGen
774	N-linked (GlcNAc...) asparagine			UniProt GlyGen
869	N-linked (GlcNAc...) asparagine		G80920RR	UniProt GlyGen
991	N-linked (GlcNAc...) asparagine			UniProt GlyGen
1026		34105348 34418053	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Degradation of the extracellular matrix	Mus musculus
HDL assembly	Mus musculus
Platelet degranulation	Mus musculus
Regulation of FXIIa and plasma kallikrein activity	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements