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Glutamine-dependent NAD(+) synthetase

Summary

UniProt ID: Q6IA69
Gene Symbol: NADSYN1
Gene ID: 55191
Organism: Homo sapiens (human)

External Links

PubChem: Q6IA69
The Human Metabolome Database: HMDBP03241
The O-GlcNAc Database: Q6IA69
Re-Glyco: Q6IA69

Annotation

Keyword: 3D-structure ATP-binding Alternative splicing Disease variant Ligase NAD Proteomics identification Reference proteome

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	Reference
NAD+ biosynthetic process	IBA	GO_REF
NAD+ biosynthetic process	IEA	GO_REF GO_REF
'de novo' NAD+ biosynthetic process from L-tryptophan	IMP	PMID
'de novo' NAD+ biosynthetic process from L-tryptophan	IEA	GO_REF GO_REF
NAD+ biosynthetic process via the salvage pathway	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

NAD+ metabolic process [inference]

NAD+ biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nucleotide salvage [inference]

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nicotinamide nucleotide metabolic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

NAD+ metabolic process [inference]

NAD+ biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nucleotide salvage [inference]

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

NAD+ metabolic process [inference]

NAD+ biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nucleotide salvage [inference]

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nicotinamide nucleotide metabolic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

NAD+ metabolic process [inference]

NAD+ biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nucleotide salvage [inference]

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nucleotide salvage [inference]

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nucleotide salvage [inference]

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

metabolic compound salvage [inference]

purine-containing compound salvage [inference]

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nucleotide salvage [inference]

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

purine-containing compound salvage [inference]

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

pyridine-containing compound biosynthetic process [inference]

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nucleotide salvage [inference]

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

indole-containing compound metabolic process [inference]

L-tryptophan metabolic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nucleotide salvage [inference]

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

NAD+ metabolic process [inference]

NAD+ biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nucleotide salvage [inference]

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nicotinamide nucleotide metabolic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

NAD+ metabolic process [inference]

NAD+ biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nucleotide salvage [inference]

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

L-tryptophan metabolic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

proteinogenic amino acid metabolic process [inference]

L-tryptophan metabolic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

L-tryptophan metabolic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

L-tryptophan metabolic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

proteinogenic amino acid metabolic process [inference]

L-tryptophan metabolic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

alpha-amino acid metabolic process [inference]

L-amino acid metabolic process [inference]

L-tryptophan metabolic process [inference]

'de novo' NAD+ biosynthetic process from L-tryptophan

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

NAD+ metabolic process [inference]

NAD+ biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nucleotide salvage [inference]

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nicotinamide nucleotide metabolic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

NAD+ metabolic process [inference]

NAD+ biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

nucleotide salvage [inference]

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

NAD+ metabolic process [inference]

NAD+ biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

purine-containing compound salvage [inference]

purine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

pyridine-containing compound metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

NAD+ metabolic process [inference]

NAD+ biosynthetic process

pyridine-containing compound biosynthetic process [inference]

pyridine nucleotide biosynthetic process [inference]

nicotinamide nucleotide biosynthetic process [inference]

NAD+ biosynthetic process

pyridine nucleotide salvage [inference]

NAD+ biosynthetic process via the salvage pathway

Displaying **all 4** entries
GO Term	Evidence Code	Reference
cytoplasm	IBA	GO_REF
cytoplasm	IEA	GO_REF
cytosol	TAS	Reactome
cytosol	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

Displaying entries **1 - 5** of 7 in total

1

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Last »
GO Term	Evidence Code	Reference
NAD+ synthase (glutamine-hydrolyzing) activity	EXP	PMID
NAD+ synthase (glutamine-hydrolyzing) activity	IMP	PMID
NAD+ synthase (glutamine-hydrolyzing) activity	IBA	GO_REF
NAD+ synthase (glutamine-hydrolyzing) activity	IEA	GO_REF GO_REF GO_REF GO_REF GO_REF
glutaminase activity	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

glutaminase activity

ligase activity [inference]

ligase activity, forming carbon-nitrogen bonds [inference]

carbon-nitrogen ligase activity, with glutamine as amido-N-donor [inference]

NAD+ synthase (glutamine-hydrolyzing) activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYESDTLLHSFQVLAALVESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWTPHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSVFAQGSQFSLDDVEVLTATLDLEDVRSYRAEISSRNLAASRASPYPRVKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGVDSAATACLIYSMCCQVCEAVRSGNEEVLADVRTIVNQISYTPQDPRDLCGRILTTCYMASKNSSQETCTRARELAQQIGSHHISLNIDPAVKAVMGIFSLVTGKSPLFAAHGGSSRENLALQNVQARIRMVLAYLFAQLSLWSRGVHGGLLVLGSANVDESLLGYLTKYDCSSADINPIGGISKTDLRAFVQFCIQRFQLPALQSILLAPATAELEPLADGQVSQTDEEDMGMTYAELSVYGKLRKVAKMGPYSMFCKLLGMWRHICTPRQVADKVKRFFSKYSMNRHKMTTLTPAYHAENYSPEDNRFDLRPFLYNTSWPWQFRCIENQVLQLERAEPQSLDGVD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
280		38253038	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Nicotinate metabolism	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3070	high grade glioma	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements