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Hemojuvelin

Summary

UniProt ID

Q6ZVN8

Gene Symbol

HFE2
HJV
RGMC

Gene ID

148738

Organism

Homo sapiens (human)

External Links

GlyGen: Q6ZVN8
PubChem: Q6ZVN8
The Human Metabolome Database: HMDBP08689
Re-Glyco: Q6ZVN8

Annotation

Keyword

3D-structure
Alternative splicing
Autocatalytic cleavage
Cell membrane
Disease variant
Disulfide bond
GPI-anchor
Phosphoprotein
Reference proteome
Signal

Gene Ontology (GO)

Displaying **all 7** entries
GO Term
extracellular space
plasma membrane
plasma membrane protein complex
cell surface
side of membrane
BMP receptor complex
HFE-transferrin receptor complex

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 10** entries
GO Term
positive regulation of transcription by RNA polymerase II
activin receptor signaling pathway
negative regulation of transcription by RNA polymerase II
intracellular iron ion homeostasis
BMP signaling pathway
negative regulation of BMP signaling pathway
multicellular organismal-level iron ion homeostasis
protein autoprocessing
transcription by RNA polymerase II
cellular response to BMP stimulus

Displaying **all 4** entries
GO Term
signaling receptor binding
transferrin receptor binding
coreceptor activity
BMP binding

Annotation information from UniProt.

Sequence

MGEPGQSPSPRSSHGSPPTLSTLTLLLLLCGHAHSQCKILRCNAEYVSSTLSLRGGGSSGALRGGGGGGRGGGVGSGGLCRALRSYALCTRRTARTCRGDLAFHSAVHGIEDLMIQHNCSRQGPTAPPPPRGPALPGAGSGLPAPDPCDYEGRFSRLHGRPPGFLHCASFGDPHVRSFHHHFHTCRVQGAWPLLDNDFLFVQATSSPMALGANATATRKLTIIFKNMQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLSSATLLAPLLSGLFVLWLCIQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
118	N-linked (GlcNAc...) asparagine	UniProt GlyGen
125		GlyGen
213	N-linked (GlcNAc...) asparagine	UniProt GlyGen
372	N-linked (GlcNAc...) asparagine	UniProt GlyGen