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Guidelines

MIRAGE

Eukaryotic translation initiation factor 2 subunit 1

Summary

UniProt ID: Q6ZWX6
Gene Symbol: Eif2s1 Eif2a
Gene ID: 13665
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q6ZWX6
PubChem: Q6ZWX6
The O-GlcNAc Database: Q6ZWX6
O-GlcNAcAtlas: Q6ZWX6
Re-Glyco: Q6ZWX6

Annotation

Keyword: Acetylation Cytoplasm Initiation factor Mitochondrion Phosphoprotein RNA-binding Reference proteome Translation regulation

Gene Ontology (GO)

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	Reference
mitophagy	ISS	GO_REF
mitophagy	ISO	GO_REF
mitophagy	IEA	GO_REF
translation	IDA	PMID PMID PMID
translational initiation	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

ER-nucleus signaling pathway [inference]

PERK-mediated unfolded protein response

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

intracellular signaling cassette [inference]

integrated stress response signaling [inference]

metabolic process [inference]

translational initiation

catabolic process [inference]

autophagy [inference]

autophagy of mitochondrion [inference]

mitophagy

macroautophagy [inference]

mitophagy

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

primary metabolic process [inference]

protein metabolic process [inference]

translation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to heat

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

integrated stress response signaling [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

process utilizing autophagic mechanism [inference]

autophagy [inference]

autophagy of mitochondrion [inference]

mitophagy

macroautophagy [inference]

mitophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

mitochondrial respirasome assembly

organelle assembly [inference]

membraneless organelle assembly [inference]

stress granule assembly

cellular component assembly [inference]

protein-containing complex assembly [inference]

mitochondrial respiratory chain complex assembly [inference]

mitochondrial respirasome assembly

organelle assembly [inference]

membraneless organelle assembly [inference]

stress granule assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

mitochondrial respiratory chain complex assembly [inference]

mitochondrial respirasome assembly

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

cellular response to oxidative stress

response to heat [inference]

cellular response to heat

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to heat

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

integrated stress response signaling [inference]

response to starvation [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to amino acid starvation [inference]

cellular response to amino acid starvation

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat [inference]

cellular response to heat

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

cellular response to UV

cellular response to light stimulus [inference]

cellular response to UV

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to amino acid starvation [inference]

cellular response to amino acid starvation

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

response to kainic acid

response to metal ion [inference]

response to manganese ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

response to nitrogen compound [inference]

response to kainic acid

response to oxygen-containing compound [inference]

response to kainic acid

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to heat

response to endoplasmic reticulum stress

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

response to manganese-induced endoplasmic reticulum stress

cellular response to chemical stress [inference]

integrated stress response signaling [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to metal ion [inference]

cellular response to manganese ion [inference]

response to manganese-induced endoplasmic reticulum stress

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

ER-nucleus signaling pathway [inference]

PERK-mediated unfolded protein response

endoplasmic reticulum unfolded protein response [inference]

PERK-mediated unfolded protein response

intracellular signaling cassette [inference]

integrated stress response signaling [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

regulation of translational initiation in response to stress

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of translation in response to stress [inference]

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

regulation of epithelial cell apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

regulation of type B pancreatic cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of type B pancreatic cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

negative regulation of protein metabolic process [inference]

negative regulation of translation [inference]

negative regulation of translational initiation [inference]

negative regulation of translational initiation in response to stress

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	Reference
nucleus	IDA	PMID
cytoplasm	IDA	PMID
mitochondrion	ISS	GO_REF
mitochondrion	ISO	GO_REF
mitochondrion	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

eukaryotic translation initiation factor 2 complex

ribonucleoprotein complex [inference]

translation initiation ternary complex

cytosolic translation preinitiation complex [inference]

eukaryotic 48S preinitiation complex

cellular anatomical structure [inference]

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

glial cell projection [inference]

astrocyte projection [inference]

astrocyte end-foot [inference]

glial limiting end-foot

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular membraneless organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

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GO Term	Evidence Code	Reference
RNA binding	IEA	GO_REF
translation initiation factor activity	ISS	GO_REF
translation initiation factor activity	ISO	GO_REF
translation initiation factor activity	IDA	PMID
translation initiation factor activity	IBA	GO_REF

GO Hierarchy

molecular function

binding [inference]

nucleic acid binding [inference]

RNA binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding

translation factor activity [inference]

translation initiation factor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTETMPIKINLIAPPRYVMTTTTLERTEGLSVLNQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQLERLERENAEVDGDDDAEEMEAKAED

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
220			G49108TO	GlyGen
222		22645316 34678516 35822049 37453647 37507081 40885482	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
ABC-family protein mediated transport	Mus musculus
Cellular response to mitochondrial stress	Mus musculus
Formation of the ternary complex, and subsequently, the 43S complex	Mus musculus
GTP hydrolysis and joining of the 60S ribosomal subunit	Mus musculus
L13a-mediated translational silencing of Ceruloplasmin expression	Mus musculus
PERK regulates gene expression	Mus musculus
Recycling of eIF2:GDP	Mus musculus
Ribosomal scanning and start codon recognition	Mus musculus
Translation initiation complex formation	Mus musculus

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026