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Sodium- and chloride-dependent glycine transporter 2

Summary

UniProt ID: Q761V0
Gene Symbol: Slc6a5 Glyt2
Gene ID
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q761V0
PubChem: Q761V0
The O-GlcNAc Database: Q761V0
O-GlcNAcAtlas: Q761V0
Re-Glyco: Q761V0

Annotation

Keyword: Alternative splicing Cell membrane Disulfide bond Glycoprotein Metal-binding Neurotransmitter transport Phosphoprotein Reference proteome Sodium Symport Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
neurotransmitter uptake	IDA	PMID
neurotransmitter uptake	IMP	PMID
glycine transport	ISO	GO_REF
sodium ion transmembrane transport	IBA	GO_REF
synaptic transmission, glycinergic	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glycinergic

transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

carboxylic acid transmembrane transport [inference]

glycine import across plasma membrane

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

neurotransmitter transport [inference]

neurotransmitter uptake

neurotransmitter reuptake

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

neutral amino acid transport [inference]

glycine transport

glycine import across plasma membrane

organic cation transport [inference]

glycine transport

glycine import across plasma membrane

organic anion transport [inference]

carboxylic acid transport [inference]

glycine transport

glycine import across plasma membrane

carboxylic acid transmembrane transport [inference]

glycine import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

glycine transport

glycine import across plasma membrane

carboxylic acid transmembrane transport [inference]

glycine import across plasma membrane

transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

carboxylic acid transmembrane transport [inference]

glycine import across plasma membrane

nitrogen compound transport [inference]

glycine transport

glycine import across plasma membrane

import into cell [inference]

neurotransmitter uptake

neurotransmitter reuptake

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

glycine import across plasma membrane

establishment of localization in cell [inference]

neurotransmitter reuptake

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glycinergic

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
endosome	ISO	GO_REF
plasma membrane	ISS	GO_REF
plasma membrane	ISO	GO_REF GO_REF
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

glycinergic synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule

Displaying **all 5** entries
GO Term	Evidence Code	Reference
glycine transmembrane transporter activity	ISO	GO_REF
glycine:sodium symporter activity	ISS	GO_REF
glycine:sodium symporter activity	ISO	GO_REF GO_REF
glycine:sodium symporter activity	IBA	GO_REF
metal ion binding

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

organic acid:sodium symporter activity [inference]

glycine:sodium symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

organic acid:sodium symporter activity [inference]

glycine:sodium symporter activity

amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

neutral L-amino acid transmembrane transporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

glycine transmembrane transporter activity

glycine:sodium symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

neutral L-amino acid:sodium symporter activity [inference]

glycine:sodium symporter activity

organic acid:sodium symporter activity [inference]

glycine:sodium symporter activity

carboxylic acid transmembrane transporter activity [inference]

glycine transmembrane transporter activity

glycine:sodium symporter activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MDCSAPKEMNKQPANILEAAVPGHRDSPRAPRTSPEQDLPAEAPAATVQPPRVPRSASTGAQTFQSADARACEAQQSGVGFCNLSSPRAQATSAALRDLSEGHSAQANPPSGPAGAGNALHCKIPALRGPEEDANVSVGKGTLEHNNTPAVGWVNMSQSTVVLGTDGIASVLPGSVATTTIPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTMVNFTSQTNKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLAFCLFLAWVIVYASLAKGIKSSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFKPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMYLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
56		22645316 40021952	G49108TO	GlyGen The O-GlcNAc Database
83			G44050CO	GlyGen
135			G02815KT	GlyGen
137		22645316 40021952	G49108TO	The O-GlcNAc Database
345	N-linked (GlcNAc...) asparagine			UniProt GlyGen
355	N-linked (GlcNAc...) asparagine			UniProt GlyGen
360	N-linked (GlcNAc...) asparagine			UniProt GlyGen
366	N-linked (GlcNAc...) asparagine			UniProt GlyGen
687				GlyGen
714	N-linked (GlcNAc...) asparagine			UniProt GlyGen