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Histone lysine demethylase PHF8

Summary

UniProt ID: Q80TJ7
Gene Symbol: Phf8 Kiaa1111
Gene ID: 320595
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q80TJ7
PubChem: Q80TJ7
The O-GlcNAc Database: Q80TJ7
Re-Glyco: Q80TJ7

Annotation

Keyword: 3D-structure Activator Alternative splicing Cell cycle Chromatin regulator Dioxygenase Iron Nucleus Phosphoprotein Reference proteome Transcription regulation Zinc-finger

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	Reference
G1/S transition of mitotic cell cycle	ISS	GO_REF
G1/S transition of mitotic cell cycle	ISO	GO_REF
G1/S transition of mitotic cell cycle	IEA	GO_REF
chromatin remodeling	IBA	GO_REF
regulation of transcription by RNA polymerase II	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell cycle process [inference]

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

G1/S transition of mitotic cell cycle

cell cycle G1/S phase transition [inference]

G1/S transition of mitotic cell cycle

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

G1/S transition of mitotic cell cycle

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization [inference]

chromatin remodeling

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of chromatin organization [inference]

negative regulation of heterochromatin organization [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of heterochromatin formation [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of rDNA heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of heterochromatin formation [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of rDNA heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase I [inference]

positive regulation of transcription by RNA polymerase I

regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of chromatin organization [inference]

negative regulation of heterochromatin organization [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of chromatin organization [inference]

negative regulation of heterochromatin organization [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of chromatin organization [inference]

regulation of heterochromatin organization [inference]

regulation of heterochromatin formation [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

regulation of rDNA heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

negative regulation of heterochromatin organization [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

negative regulation of chromatin organization [inference]

negative regulation of heterochromatin organization [inference]

negative regulation of heterochromatin formation [inference]

negative regulation of rDNA heterochromatin formation

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GO Term	Evidence Code	Reference
nucleus	ISS	GO_REF
nucleus	ISO	GO_REF
nucleus	IEA	GO_REF GO_REF
nucleoplasm	ISO	GO_REF
nucleoplasm	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

nucleoplasm

membrane [inference]

organelle membrane [inference]

nuclear membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nucleolus

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	Reference
chromatin binding	ISS	GO_REF
chromatin binding	ISO	GO_REF
chromatin binding	IEA	GO_REF
transcription coregulator activity	IBA	GO_REF
iron ion binding	ISS	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

histone H4K20 demethylase activity

histone H3K36 demethylase activity

histone H3K36me/H3K36me2 demethylase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

histone H4K20 demethylase activity

histone H3K36 demethylase activity

histone H3K36me/H3K36me2 demethylase activity

demethylase activity [inference]

protein demethylase activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K9 demethylase activity

histone H3K9me/H3K9me2 demethylase activity

histone H3K36 demethylase activity

histone H3K36me/H3K36me2 demethylase activity

histone H3K27me2/H3K27me3 demethylase activity

histone H4 demethylase activity [inference]

histone H4K20 demethylase activity

catalytic activity, acting on a protein [inference]

protein demethylase activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K9 demethylase activity

histone H3K9me/H3K9me2 demethylase activity

histone H3K36 demethylase activity

histone H3K36me/H3K36me2 demethylase activity

histone H3K27me2/H3K27me3 demethylase activity

histone H4 demethylase activity [inference]

histone H4K20 demethylase activity

histone modifying activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K9 demethylase activity

histone H3K9me/H3K9me2 demethylase activity

histone H3K36 demethylase activity

histone H3K36me/H3K36me2 demethylase activity

histone H3K27me2/H3K27me3 demethylase activity

histone H4 demethylase activity [inference]

histone H4K20 demethylase activity

binding [inference]

chromatin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

chromatin-protein adaptor activity [inference]

histone reader activity [inference]

histone H3 reader activity [inference]

histone H3K4me3 reader activity

transcription regulator activity [inference]

transcription coregulator activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MASVPVYCLCRLPYDVTRFMIECDMCQDWFHGSCVGVEEEKAADIDLYHCPNCEVLHGPSIMKKRRGSSKGHDNHKGKPLKTGSSMFIRELRGRTFDSSDEVILKPTGSQLTVEFLEENSFSVPILVLKKDGLGMTLPSPSFTVRDVEHYVGSDKEIDVIDVARQADCKMKLGDFVKYYYSGKREKVLNVISLEFSDTRLSNLVETPRIVRKLSWVENLWPEECVFERPNVQKYCLMSVRDSYTDFHIDFGGTSVWYHVLKGEKIFYLIRPTNANLTLFECWSSSSNQNEMFFGDQVEKCYKCSVKQGQTLFIPTGWIHAVLTPVDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFKFPNFETICWYVGKHILDIFRGLRENRRHPASYLVHGGKALNLAFRAWTKKEALPDHEDEIPETVRTVQLIKDLAREIRLVEDIFQQNVGKTSNIFGLQRIFPAGSIPLTKPAHSTSVSMSKLSLPSKNGSKKKGLKPKDIFKKAERKGKQSSALGPAGQLSYNLMDPYSHQALKTGPSQKAKFNMSGTSLNDSDDDSADMDLDGSENPLALLMANGSTKRMKSVSKSRRAKIAKKVDSARLVAEQVMGDEFDLDSDDELQIDERLGKEKANLLIRSKFPRKLPRAKPCSDPNRIREPGEVEFDIEEDYTTDEDMVEGVESKLGNGSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQEAIQGMLCMANLQSSSSSPATSSLQAWWTGGQERSSGSSSSGLGTVSSSPASQRTPGKRPIKRPAYWKNESEEEENASLDEQDSLGACFKDAEYIYPSLESDDDDPALKSRPKKKKNSDDAPWSPKARVTPTLPKQDRPVREGTRVASIETGLAAAAAKLAQQELQKAQKKKYIKKKPLLKEVEQPRPQDSNPIMTMPAPTVATTPQPDTSSSPQPPPEPKQEALSGSLADHEYTARPNAFGMAQANRSTTPMAPGVFLTQRRPSVGSQSSQAGQGKRPKKGLATAKQRLGRILKIHRNGKLLL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	PubMed ID	GlyTouCan ID	Source
863	34418053	G49108TO	The O-GlcNAc Database
870	34418053	G49108TO	The O-GlcNAc Database
920			GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
HDMs demethylate histones	Mus musculus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060812	syndromic X-linked intellectual disability Siderius type	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements