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Sialic acid-binding Ig-like lectin 10

Summary

UniProt ID: Q80ZE3
Gene Symbol: Siglec10 Siglecg
Gene ID: 243958
Organism: Mus musculus (house mouse)

External Links

The Human Metabolome Database: HMDBP14320
Re-Glyco: Q80ZE3

Annotation

Keyword: Adaptive immunity Cell adhesion Cell membrane Disulfide bond Glycoprotein Immunoglobulin domain Innate immunity Lectin Phosphoprotein Reference proteome Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
hematopoietic progenitor cell differentiation	IMP	PMID
adaptive immune response
negative regulation of immunoglobulin production	IGI	PMID
cell adhesion	IBA	GO_REF
regulation of B cell proliferation	IMP	PMID

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

cellular process [inference]

cell adhesion

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

hematopoietic progenitor cell differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation

regulation of B cell activation [inference]

regulation of B cell proliferation

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

negative regulation of immunoglobulin production

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of immune response

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

negative regulation of calcium-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to wounding

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to wounding

negative regulation of response to wounding [inference]

negative regulation of inflammatory response to wounding

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

negative regulation of calcium-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to wounding

regulation of inflammatory response [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to wounding

regulation of inflammatory response to wounding [inference]

negative regulation of inflammatory response to wounding

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to wounding

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to wounding

negative regulation of response to wounding [inference]

negative regulation of inflammatory response to wounding

regulation of immune response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to wounding

regulation of inflammatory response [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to wounding

regulation of inflammatory response to wounding [inference]

negative regulation of inflammatory response to wounding

regulation of response to wounding [inference]

regulation of inflammatory response to wounding [inference]

negative regulation of inflammatory response to wounding

negative regulation of response to wounding [inference]

negative regulation of inflammatory response to wounding

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

negative regulation of calcium-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

negative regulation of immunoglobulin production

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

negative regulation of immunoglobulin production

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of cell population proliferation [inference]

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation

regulation of B cell activation [inference]

regulation of B cell proliferation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation

regulation of B cell activation [inference]

regulation of B cell proliferation

Displaying **all 3** entries
GO Term	Evidence Code	Reference
plasma membrane	ISO	GO_REF
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	Reference
phosphatase binding	ISO	GO_REF
carbohydrate binding
sialic acid binding	ISO	GO_REF
sialic acid binding	IBA	GO_REF
SH2 domain binding	ISO	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

phosphatase binding

protein domain specific binding [inference]

SH2 domain binding

carbohydrate binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

sialic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

sialic acid binding

carbohydrate derivative binding [inference]

sialic acid binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSLLLFLLSFLLDGPQGQMESYFLQVQRIVKAQEGLCIFVPCSFSSPEGKWLNRSPLYGYWFKGIRKPSLSFPVATNNKDKVLEWEARGRFQLLGDISKKNCSLLIKDVQWGDSTNYFFRMERGFERFSFKEEFRLQVEALTQKPDIFIPEVLEPGEPVTVVCLFSWTFNQCPAPSFSWMGDAVSFQESRPHTSNYSVLSFIPGLQHHDTELTCQLDFSRMSTQRTVRLRVAYAPRSLAISIFHDNVSVPDLHENPSHLEVQQGQSLRLLCTADSQPPATLSWVLEDQVLSWSSPVGSRTLALELPWVKAGDSGHYTCQAENRLGSQQHTLDLSVLYPPQDLRVTVSQANRTVLEILRNAISLPVLEGQSLCLVCVTYSNPPANVSWAWVTQTLIPIQSSEPGVLELPLVQREHEGEFTCAAQNPLGAQRISLSLSVHYPPQMSSPSCSWEAKGLHCNCSSRAWPAPSLRWRLGEGLLEGNSSNASFTVTFSSLGPWVNSSLSLLQELGPSLWLSCESWNTHGAQTTSVLLLPDKDSATAFSKGAVLGFGITALLALCLIVVIVKTLQKKGTQEEPSRPKLSRGSTILDYINVVPKTRSLARNWKAEPDAPSRSSPLDTHFPKPKKKQKDPHFTYPGCPDPTSSSQVPVSENNPEELHYAALNFSRLRLQETQDPQDTYSDYTEVRVH

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
195	N-linked (GlcNAc...) asparagine			UniProt
246	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
DAP12 interactions	Mus musculus
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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