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Vesicular glutamate transporter 3

Summary

UniProt ID: Q8BFU8
Gene Symbol: Slc17a8 Vglut3
Gene ID: 216227
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q8BFU8
The O-GlcNAc Database: Q8BFU8
Re-Glyco: Q8BFU8

Annotation

Keyword: Cell membrane Chloride channel Cytoplasmic vesicle Deafness Glycoprotein Hearing Neurotransmitter transport Phosphate transport Reference proteome Sodium transport Symport Synaptosome Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	Reference
neural retina development	IEA	GO_REF
sensory perception of sound
L-glutamate transmembrane transport	ISO	GO_REF GO_REF
L-glutamate transmembrane transport	IDA	PMID PMID
L-glutamate transmembrane transport	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

intercellular transport [inference]

neurotransmitter loading into synaptic vesicle

transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

developmental process [inference]

anatomical structure development [inference]

homeostatic process [inference]

chemical homeostasis [inference]

inorganic ion homeostasis [inference]

phosphate ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter loading into synaptic vesicle

amino acid transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

acidic amino acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

intercellular transport [inference]

neurotransmitter loading into synaptic vesicle

inorganic anion transport [inference]

phosphate ion transport [inference]

sodium-dependent phosphate transport

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

nitrogen compound transport [inference]

L-amino acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

establishment of localization in cell [inference]

neurotransmitter loading into synaptic vesicle

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

regulation of L-glutamate import across plasma membrane [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of glutamate uptake involved in transmission of nerve impulse [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of organic acid transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of L-glutamate import across plasma membrane [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of glutamate uptake involved in transmission of nerve impulse [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter uptake [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter uptake [inference]

positive regulation of neurotransmitter uptake [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of glutamate uptake involved in transmission of nerve impulse [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter uptake [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of amine transport [inference]

regulation of acetylcholine uptake

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of amino acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of L-glutamate import across plasma membrane [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of glutamate uptake involved in transmission of nerve impulse [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter uptake [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of L-glutamate import across plasma membrane [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of glutamate uptake involved in transmission of nerve impulse [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of biological quality [inference]

regulation of synapse structure or activity

Displaying entries **1 - 5** of 34 in total

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GO Term	Evidence Code	Reference
multivesicular body	ISO	GO_REF
multivesicular body	IEA	GO_REF
plasma membrane	ISS	GO_REF
plasma membrane	IEA	GO_REF
synaptic vesicle	IDA	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

clathrin-sculpted glutamate transport vesicle membrane

exocytic vesicle membrane [inference]

synaptic vesicle membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-sculpted glutamate transport vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

clathrin-sculpted glutamate transport vesicle membrane

exocytic vesicle membrane [inference]

synaptic vesicle membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-sculpted glutamate transport vesicle membrane

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

glial cell projection [inference]

astrocyte projection [inference]

astrocyte end-foot [inference]

glial limiting end-foot

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus

presynapse [inference]

axon terminus

pericellular basket

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
chloride channel activity	ISS	GO_REF
chloride channel activity	ISO	GO_REF
chloride channel activity	IEA	GO_REF
L-glutamate transmembrane transporter activity	IBA	GO_REF
neurotransmitter transmembrane transporter activity	IBA	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

neurotransmitter transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

amino acid transmembrane transporter activity [inference]

acidic amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

L-glutamate uniporter activity

L-amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

L-glutamate uniporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

phosphate transmembrane transporter activity [inference]

sodium:phosphate symporter activity

uniporter activity [inference]

membrane potential driven uniporter activity [inference]

L-glutamate uniporter activity

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

carboxylic acid transmembrane transporter activity [inference]

L-amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

L-glutamate uniporter activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPFKAFDTFKEKILKPGKEGVKNAVGDSLGILQRKIDGTNEEEDAIELNEEGRPVQTSRAHRPVCDCSCCGIPKRYICDCSCCGIPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAASRVFGAAIFLTSTLNMFIPSAARVHYGCVMGVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNAERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQDWADPENLSEDKCGIIDQDELAEETELNHETFVSPRKKMSYGATTQNCEVQKTEWRQQRESAFDGEEPLSYQAEGDFSETS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
119	N-linked (GlcNAc...) asparagine			UniProt GlyGen
398		33300544 36852467	G49108TO	The O-GlcNAc Database
399		33300544 36852467	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
SLC-mediated transport of neurotransmitters	Mus musculus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110555	autosomal dominant nonsyndromic deafness 25	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements