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Structure-specific endonuclease subunit EME1

Summary

UniProt ID: Q8BJW7
Gene Symbol: Eme1
Gene ID: 268465
Organism: Mus musculus (house mouse)

External Links

PubChem: Q8BJW7
The O-GlcNAc Database: Q8BJW7
Re-Glyco: Q8BJW7

Annotation

Keyword: DNA recombination DNA repair Isopeptide bond Magnesium Metal-binding Nucleus Phosphoprotein Reference proteome Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
resolution of meiotic recombination intermediates	IBA	GO_REF
double-strand break repair	ISO	GO_REF
double-strand break repair	IBA	GO_REF
double-strand break repair	IEA	GO_REF
replication fork processing	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

resolution of DNA recombination intermediates [inference]

resolution of mitotic recombination intermediates

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

resolution of DNA recombination intermediates [inference]

resolution of mitotic recombination intermediates

cell cycle process [inference]

meiotic cell cycle process [inference]

meiosis I cell cycle process [inference]

resolution of meiotic recombination intermediates

mitotic cell cycle process [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

cellular response to biotic stimulus [inference]

response to cell cycle checkpoint signaling [inference]

response to DNA integrity checkpoint signaling [inference]

response to DNA damage checkpoint signaling [inference]

response to intra-S DNA damage checkpoint signaling

reproductive process [inference]

meiotic cell cycle process [inference]

meiosis I cell cycle process [inference]

resolution of meiotic recombination intermediates

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

response to biotic stimulus [inference]

cellular response to biotic stimulus [inference]

response to cell cycle checkpoint signaling [inference]

response to DNA integrity checkpoint signaling [inference]

response to DNA damage checkpoint signaling [inference]

response to intra-S DNA damage checkpoint signaling

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

response to cell cycle checkpoint signaling [inference]

response to DNA integrity checkpoint signaling [inference]

response to DNA damage checkpoint signaling [inference]

response to intra-S DNA damage checkpoint signaling

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

cellular response to biotic stimulus [inference]

response to cell cycle checkpoint signaling [inference]

response to DNA integrity checkpoint signaling [inference]

response to DNA damage checkpoint signaling [inference]

response to intra-S DNA damage checkpoint signaling

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

signal transduction in response to DNA damage [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

regulation of cell cycle phase transition [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA damage checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA damage checkpoint signaling [inference]

mitotic intra-S DNA damage checkpoint signaling

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
nuclear chromosome	ISO	GO_REF
nuclear chromosome	IEA	GO_REF
chromatin	IDA	PMID
heterochromatin	IDA	PMID
nucleolus	IEA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

endonuclease complex [inference]

endodeoxyribonuclease complex

Holliday junction resolvase complex

catalytic complex [inference]

endonuclease complex [inference]

endodeoxyribonuclease complex

Holliday junction resolvase complex

cellular anatomical structure [inference]

chromatin

heterochromatin

replication fork [inference]

nuclear replication fork

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

chromosome [inference]

nuclear chromosome

nucleolus

intracellular organelle [inference]

intracellular membraneless organelle [inference]

chromosome [inference]

nuclear chromosome

nucleolus

Displaying **all 5** entries
GO Term	Evidence Code	Reference
DNA binding	ISO	GO_REF
DNA binding	IEA	GO_REF
crossover junction DNA endonuclease activity	ISO	GO_REF
crossover junction DNA endonuclease activity	IEA	GO_REF
metal ion binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

crossover junction DNA endonuclease activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

endonuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

crossover junction DNA endonuclease activity

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

crossover junction DNA endonuclease activity

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

DNA endonuclease activity, producing 3'-phosphomonoesters [inference]

crossover junction DNA endonuclease activity

binding [inference]

nucleic acid binding [inference]

DNA binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MALRRLSLSRLSTESDSEDLPTFAFLKKEPSSTNRKPPQRAKNIVVVTSDSEASCPPSPGLKGPPCVPSAAGAPPQAGPVRVLSSSSEDEDVFVPLAERITCKLLTSKQLCPELSSSSLKTGLDGQNNASAPCDWKRQPWPKIPDVPLHGALEKSAANDEDSLLDDQCRQLPTYQATCRELAVSKTNSDRPLPKKRTKHIQTVQSGGSQGCWRPGQASRKENTPRQHERKKKAEMIKRLKAQRPEECLKHIVVVLDPVLLQMEGGGQLLGALQAMECSCVIEVQAIPRSITWRRRRTELVEDGDDWMEEPTILVLVLAEVFMSMAYNLKQASPSSTEKGKETLRSFVTDVTAKTGKALSLVIVDQEKCFRPQNPPRRRKSGMANKQAKAKHQQRQESSTGLMVSRADMEKALVDLQLYTEAQAWMVQSWKELADFTCAFTKAVAEAPFKKLRDQVTFSFFLEKDWAGGMKVDQSGRGLALIWRRQIQQLNRVSSEMASAIVDAYPSPQLLVQAYQRCFSEQERQNLLADIQVRRGEGVTATSRRVGPELSRRIYLQMTTAQPDLILDSVD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites