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Sialin

Summary

UniProt ID: Q8BN82
Gene Symbol: Slc17a5
Gene ID: 235504
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0006304
PubChem: Q8BN82
Re-Glyco: Q8BN82

Annotation

Keyword: Alternative splicing Amino-acid transport Cell membrane Cytoplasmic vesicle Glycoprotein Lysosome Reference proteome Symport Synapse Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
amino acid transport
response to bacterium	IEP	PMID
sialic acid transport	ISO	GO_REF
sialic acid transport	IBA	GO_REF
sialic acid transport	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

intercellular transport [inference]

neurotransmitter loading into synaptic vesicle

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

localization [inference]

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter loading into synaptic vesicle

amino acid transport

intercellular transport [inference]

neurotransmitter loading into synaptic vesicle

organic anion transport [inference]

carboxylic acid transport [inference]

sialic acid transport

organic acid transport [inference]

carboxylic acid transport [inference]

sialic acid transport

establishment of localization in cell [inference]

neurotransmitter loading into synaptic vesicle

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	Reference
lysosome	IBA	GO_REF
lysosomal membrane	ISS	GO_REF
lysosomal membrane	ISO	GO_REF GO_REF
lysosomal membrane	IMP	PMID
lysosomal membrane	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

cell junction [inference]

synapse [inference]

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
sialic acid transmembrane transporter activity	ISO	GO_REF
sialic acid transmembrane transporter activity	IBA	GO_REF
sialic acid transmembrane transporter activity	IEA	GO_REF
symporter activity
D-glucuronate transmembrane transporter activity	ISO	PMID

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity

carboxylic acid transmembrane transporter activity [inference]

uronic acid transmembrane transporter activity [inference]

glucuronate transmembrane transporter activity [inference]

D-glucuronate transmembrane transporter activity

carbohydrate derivative transmembrane transporter activity [inference]

sialic acid transmembrane transporter activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRPLLRGPAGNDDEESSDSTPLLPGARQTEAAPVCCSARYNLAILAFCGFFVLYALRVNLSVALVDMVDSNTTLTDNRTSKECAEHSAPIKVHHNHTGKKYKWDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTISHYEKEYIVSSLKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKWNFSTISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFAKGEVQSWALSDHHGHRN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
71	N-linked (GlcNAc...) asparagine	UniProt
77	N-linked (GlcNAc...) asparagine	UniProt
95	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Hyaluronan degradation	Mus musculus
Organic anion transport by SLC5/17/25 transporters	Mus musculus
Sialic acid metabolism	Mus musculus

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:3211	lysosomal storage disease	Alliance of Genome Resources
DOID:3659	sialuria	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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International Collaboration

Acknowledgements