GlyCosmos Portal

Submissions

Meckelin

Summary

UniProt ID: Q8BR76
Gene Symbol: Tmem67 Mks3
Gene ID: 329795
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0006342

GlyConnect

Meckelin

GlyGen

Q8BR76

PubChem

Q8BR76

Re-Glyco

Q8BR76

Annotation

Keyword: Alternative splicing Cell membrane Cilium Cilium biogenesis/degradation Cytoskeleton Disulfide bond Endoplasmic reticulum Glycoprotein Reference proteome Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	Reference
kidney development	IMP	PMID
determination of left/right symmetry	IMP	PMID
heart development	IMP	PMID
negative regulation of centrosome duplication	ISO	GO_REF GO_REF
negative regulation of centrosome duplication	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

photoreceptor cell outer segment organization

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube

epithelial tube branching involved in lung morphogenesis

pattern specification process [inference]

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube

epithelial tube branching involved in lung morphogenesis

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube

epithelial tube branching involved in lung morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube

epithelial tube branching involved in lung morphogenesis

anatomical structure development [inference]

animal organ development [inference]

head development

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to chemical [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

positive regulation of response to stimulus [inference]

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of microtubule-based process [inference]

regulation of centrosome cycle [inference]

regulation of centrosome duplication [inference]

negative regulation of centrosome duplication

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of cilium assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of non-motile cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of organelle assembly [inference]

regulation of cilium assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of non-motile cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of cilium assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of non-motile cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of cilium assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of non-motile cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of cytoskeleton organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of organelle assembly [inference]

regulation of cilium assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of non-motile cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of centrosome cycle [inference]

regulation of centrosome duplication [inference]

negative regulation of centrosome duplication

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of cilium assembly [inference]

positive regulation of non-motile cilium assembly

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of centrosome cycle [inference]

regulation of centrosome duplication [inference]

negative regulation of centrosome duplication

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

Displaying entries **1 - 5** of 12 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	Reference
endoplasmic reticulum membrane	ISO	GO_REF GO_REF
endoplasmic reticulum membrane	IDA	PMID
endoplasmic reticulum membrane	IEA	GO_REF
centrosome	ISO	GO_REF
axoneme	ISO	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

MKS complex

cellular anatomical structure [inference]

microtubule organizing center [inference]

centrosome

axoneme

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane

bounding membrane of organelle [inference]

ciliary membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

ciliary transition zone

Displaying **all 3** entries
GO Term	Evidence Code	Reference
filamin binding	ISO	GO_REF
unfolded protein binding
misfolded protein binding	ISO	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

filamin binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MVTRTRPVAAMAVRSRSSSRTGTAYLLLVLCEVSWAQIFSFPFRRPETCDFNQYFDISALSCAPCGANQRRDALGTSCVCLPGYHMISNNGGPSIICKKCPENMKGVTKDGWDCISCPSGLTAEGKCHCPTGHILVERNVSGSLLAQATCELCDESENSFTKANALGTRCVRCEPTFVNTSRSCSCSEPHTLTGGLCFSNTGNFHQRVISTARYGELGMSLNSEWFAKYLQATAAACWTHANLTSCQALGNMCVMNMNSYDSTTLDACRLFHYIFESTAGLISVHSVPFWRQNLPWLFYGDQPGLAPQVLSTTPLPTNFSFKGQNQLKFVAASYDIRGNFIKWQPLEGGVLQLCPDTERRLDAAYAFGTTYQQNCEISLSKLLVDFSSPVFYDVYLEYTDEEQHRYLWPIPVLNLNLQHNKLFVNQDSSSSKWLLTRRIFLVDAVSGRENDLGNQPRVIRVATQISLSIRLVPNTKNGNIYTPLLTIAYSDIDIKNAHSQSAKISFSVKYEMNQGDASVHTDIALGVLGGLAVLSSLLKTAGWKRRVGSPMIDLQTVMKFLLYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLLPMPVQEERFVTYVGCAFAMKALQFLHKFISQISIDIFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINPLFQVLTTLFFLEVVGFKNLALMDSSSSLSRNPSDYTAPYSRILRYAVATAIWLVIGIIQVVFFAAFYERFIEDKIRQFVDLCSMSNVSVFLLSHRCFGYYIHGRSVHGHADTNMEEMNMNLKREAENLCSQRGLVPNTDGQTFQIAVSSQMRQHYDRIHETLTRRNGPARLLSSSGSTFEQSIKAYHAMNKFLGSFIDHVHKEMDYFIKDKLLLERILGMEFMEPMEKSIFYNDEGHSFSSVLYYGNEATLLIFDLLFFCVVDLACQDFVLASFLTYLQQEIFRFIRNTVGQKNLATKTLVDERFLI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
139			G23505EP	GlycoProtDB GlyGen
179		30899004	G43223CG G06110VR	GlycoProtDB GlyGen GlyConnect
242	N-linked (GlcNAc...) asparagine		G46910OC	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Anchoring of the basal body to the plasma membrane	Mus musculus

Disease

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:2975	cystic kidney disease	Alliance of Genome Resources
DOID:0050545	visceral heterotaxy	Alliance of Genome Resources
DOID:0111001	Joubert syndrome 6	Alliance of Genome Resources
DOID:0050778	Meckel syndrome	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements