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Sodium/hydrogen exchanger 4

Summary

UniProt ID: Q8BUE1
Gene Symbol: Nhe4 Slc9a4
Gene ID: 110895
Organism: Mus musculus (house mouse)

External Links

Re-Glyco: Q8BUE1

Annotation

Keyword: Antiport Cell membrane Cytoplasmic vesicle Glycoprotein Phosphoprotein Reference proteome Sodium transport Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
gastric acid secretion	IMP	PMID
epithelial cell development	IMP	PMID
regulation of intracellular pH	IBA	GO_REF
transepithelial ammonium transport	IMP	PMID
potassium ion transmembrane transport

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

epithelial cell development

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

potassium ion transmembrane transport

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

gastric acid secretion

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

epithelial cell development

cellular developmental process [inference]

cell development [inference]

epithelial cell development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of intracellular pH

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

sodium ion transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

potassium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

potassium ion transmembrane transport

secretion [inference]

acid secretion [inference]

gastric acid secretion

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion import across plasma membrane

potassium ion transmembrane transport

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

transepithelial transport [inference]

transepithelial ammonium transport

nitrogen compound transport [inference]

transepithelial ammonium transport

import into cell [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

sodium ion import across plasma membrane

biological regulation [inference]

regulation of pH [inference]

regulation of intracellular pH

regulation of biological quality [inference]

regulation of intracellular pH

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
plasma membrane
basolateral plasma membrane	ISS	GO_REF
basolateral plasma membrane	ISO	GO_REF
basolateral plasma membrane	EXP	PMID
basolateral plasma membrane	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

zymogen granule membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

zymogen granule membrane

plasma membrane region [inference]

Displaying **all 4** entries
GO Term	Evidence Code	Reference
sodium:proton antiporter activity	ISS	GO_REF
sodium:proton antiporter activity	ISO	GO_REF
sodium:proton antiporter activity	IEA	GO_REF
potassium:proton antiporter activity

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

metal cation:proton antiporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

solute:potassium antiporter activity [inference]

potassium:proton antiporter activity

sodium ion transmembrane transporter activity [inference]

sodium:proton antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

solute:potassium antiporter activity [inference]

potassium:proton antiporter activity

metal cation:proton antiporter activity [inference]

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

solute:potassium antiporter activity [inference]

potassium:proton antiporter activity

metal cation:proton antiporter activity [inference]

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGPAMFMAFRLWNWLLLLAVLTRSEATSYVNESSNPTAQQAPDARFAASSSDPDEGISVFELDYDYVQIPYEVTLWILLASLAKIGFHLYHRLPHLMPESCLLIIVGALVGGIIFGTHHKSPPVMDSSIYFLYLLPPIVLESGYFMPTRPFFENIGSILWWAGLGALINAFGIGLSLYFICQIKAFGLGDINLLHNLLFGSLISAVDPVAVLAVFEEARVNEQLYMMIFGEALLNDGISVVLYNILIAFTKMHKFEDIEAVDILAGCARFVIVGCGGVFFGIIFGFISAFITRFTQNISAIEPLIVFMFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVSTIGKNHEWNWAFICFTLLFCQIWRAISVFTLFYVSNQFRTFPFSIKDQFIIFYSGVRGAGSFSLAFLLPLSLFPRKKLFVTATLVVTYFTVFFQGITIGPLVRYLDVRKTNKKESINEELHSRLMDHLKAGIEDVCGQWSHYQVRDKFKKFDHRYLRKILIRRNLPKSSIVSLYKKLEMKQAIEMVETGILSSVASPTPYQSERIQGIKRLSPEDVESMRDILTRSMYQVRQRTLSYNKYNLKPQTSEKQAKEILIRRQNTLRESMRKGQSLPWGKPAGTKNFRYLSFPYSNPQAARREARAAEPTDDDGTDSGFQPLMFSIHSRAGSLQERRQTQAVIPMKRLQRGEKALSFSYRSNTSWEDQAGWRRMDVLRPKPLFYAVAEEYDSGEQTEEETSAILSRWTAEHRHSTEHHKSHSPLLHRK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
342	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Sodium/Proton exchangers	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

International Collaboration

Acknowledgements