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Gephyrin

Summary

UniProt ID: Q8BUV3
Gene Symbol: Gphn
Gene ID: 268566
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q8BUV3
PubChem: Q8BUV3
The O-GlcNAc Database: Q8BUV3
O-GlcNAcAtlas: Q8BUV3
Re-Glyco: Q8BUV3

Annotation

Keyword: ATP-binding Cell membrane Cell projection Cytoskeleton Magnesium Metal-binding Molybdenum Molybdenum cofactor biosynthesis Multifunctional enzyme Palmitate Phosphoprotein Postsynaptic cell membrane Reference proteome Transferase

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
Mo-molybdopterin cofactor biosynthetic process	ISS	GO_REF
Mo-molybdopterin cofactor biosynthetic process	ISO	GO_REF GO_REF
Mo-molybdopterin cofactor biosynthetic process	IMP	PMID
Mo-molybdopterin cofactor biosynthetic process	IBA	GO_REF
Mo-molybdopterin cofactor biosynthetic process	IEA	GO_REF GO_REF

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organophosphate metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

organophosphate biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

biosynthetic process [inference]

organophosphate biosynthetic process [inference]

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

prosthetic group metabolic process [inference]

molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor metabolic process [inference]

Mo-molybdopterin cofactor biosynthetic process

molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor biosynthetic process

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization [inference]

establishment of synaptic specificity at neuromuscular junction

response to stimulus [inference]

response to chemical [inference]

response to metal ion

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to cell junction [inference]

protein localization to synapse [inference]

protein localization to postsynapse [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein localization to cell periphery [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

protein-containing complex localization [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

establishment of localization [inference]

establishment of protein localization

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering [inference]

neurotransmitter-gated ion channel clustering [inference]

protein localization to postsynaptic membrane [inference]

protein localization to postsynaptic specialization membrane [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

receptor localization to synapse [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

regulation of biological quality [inference]

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

neurotransmitter receptor localization to postsynaptic specialization membrane

Displaying entries **1 - 5** of 39 in total

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GO Term	Evidence Code	Reference
cytoplasm	ISO	GO_REF
cytoplasm	IBA	GO_REF
cytoplasm	IEA	GO_REF
cytosol	ISO	GO_REF
cytosol	IDA	PMID PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane region [inference]

synaptic membrane

postsynaptic membrane

extrinsic component of membrane [inference]

extrinsic component of plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

neuron spine [inference]

dendritic spine

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

intracellular organelle [inference]

intracellular membraneless organelle [inference]

postsynaptic specialization

postsynaptic density

cell body [inference]

neuronal cell body

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

postsynapse

dendritic spine

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	Reference
signaling receptor binding	ISO	GO_REF
ATP binding
cytoskeletal protein binding	TAS	PMID
nitrate reductase activity	ISO	GO_REF
protein-macromolecule adaptor activity	ISO	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on other nitrogenous compounds as donors [inference]

nitrate reductase activity

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

adenylyltransferase activity [inference]

molybdopterin adenylyltransferase activity

molybdopterin molybdotransferase activity

binding [inference]

protein binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molybdopterin cofactor binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular adaptor activity

protein-macromolecule adaptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETLIDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTLIINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGVQCEEEEEEKKDSGVASTEDSSSSHITAAALAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLSTASCPTPKQIRRPDESKGVASRVGSLKARLPSCSSTYSVSEVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	PubMed ID	GlyTouCan ID	Source
222	22645316 33300544 35822049 36852467 40021952 40885482	G49108TO	The O-GlcNAc Database
226	22645316 33300544 35822049 36852467 40021952 40885482	G49108TO	The O-GlcNAc Database
227	22645316 33300544 35822049 36852467 40021952 40885482	G49108TO	The O-GlcNAc Database
236	22645316 33300544 35822049 36852467 40021952 40885482	G49108TO	GlyGen The O-GlcNAc Database
260	22645316 33300544 35822049 36852467 40021952 40885482	G49108TO	GlyGen The O-GlcNAc Database
264	22645316 33300544 35822049 36852467 40021952 40885482	G49108TO	The O-GlcNAc Database
265		G49108TO	GlyGen