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A disintegrin and metalloproteinase with thrombospondin motifs 2

Summary

UniProt ID: Q8C9W3
Gene Symbol: Adamts2
Gene ID: 216725
Organism: Mus musculus (house mouse)

External Links

Re-Glyco: Q8C9W3

Annotation

Keyword: Collagen degradation Direct protein sequencing Disulfide bond Extracellular matrix Glycoprotein Metal-binding Metalloprotease Reference proteome Repeat Signal Zinc Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
proteolysis	IBA	GO_REF
proteolysis	IEA	GO_REF
spermatogenesis	IMP	PMID
protein processing	IMP	PMID
extracellular matrix organization	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

collagen catabolic process

collagen metabolic process [inference]

collagen catabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization

collagen fibril organization

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure development [inference]

animal organ development [inference]

Displaying **all 3** entries
GO Term	Evidence Code	Reference
extracellular matrix	IDA	PMID
extracellular matrix	IBA	GO_REF
extracellular matrix	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

external encapsulating structure [inference]

extracellular matrix

Displaying **all 4** entries
GO Term	Evidence Code	Reference
metalloendopeptidase activity	IBA	GO_REF
metalloendopeptidase activity	IEA	GO_REF GO_REF
peptidase activity	IDA	PMID
zinc ion binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MDPPAGAARRLLCPALLLLLLPPPPLLLLPPPPASVRLVAATEPPGGPPGQGAERILAVPVRTDAQGRLVSHVVSLETAGAGVRARRAALDQTSGLPGGAAQDPGGRLFYNLTVFGRDLHLRLRPNARLVAPGATVEWQGETGDTRVEPLLGSCLYVGDVADLPKASSVALSNCDGLAGLIRMEEEEFFIEPLEKGQTDQEAEQGRVHVVYRRPPTPKPPPVSEPQALDTGVSQGNLDSLSRALGVLEERINSSRRRVRRHATDDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSHAKSMSLIEIGNPSQSLENVCRWAYLQQKPDTDHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLRDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGNWGAWTPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCNPQDCPNSLADFREEQCQQWDLYFEHGDVQHHWLPHEHRDAKERCHLYCESKETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSRKQEDKCGVCGGDNTHCKVVKGTFTRSPRKQDYIKMFEIPAGARHLLIQEADTTSHHLSVKNLETGKFILNEENHLDPNSRSFIAMGVEWEYRNEDERETLQTIGPLHGTITVLVIPEGDTRISLTYKYMIHEDSLNVDDNNVLEDDAVRHEWALKKWSPCSKPCGGGSQFTKYGCRRRLDSKMVHRAFCSALAKPKAIRRACNPQECSQPVWVTGEWEPCTQSCGRTGMQVRSVRCIQPLHNNTTRSVHTKHCNDHRPESRRACNRELCPGRWRAGSWSQCSVTCGNGTQERPVLCRTADDNFGVCREERPETARICRLAPCPRNGSDPSKKSYVVQWLSRPDPDSPIQKISSKDQCQGDKSMFCRMEVLSRYCSIPSYNKLCCKSCNPPRNLSNTEDGGVEPPPGKHNDIDVFMPTLPGPTVATQVQPSPGPPLEAPLNVSSTNATEDHPETNAVDVPYKIHGVDEEVPSPNLIPRRPSLYVKTRNQRIQELINAVQRKEKPGKF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 9** entries
Position	Description	Source
111	N-linked (GlcNAc...) asparagine	UniProt
252	N-linked (GlcNAc...) asparagine	UniProt
949	N-linked (GlcNAc...) asparagine	UniProt
950	N-linked (GlcNAc...) asparagine	UniProt
994	N-linked (GlcNAc...) asparagine	UniProt
1032	N-linked (GlcNAc...) asparagine	UniProt
1099	N-linked (GlcNAc...) asparagine	UniProt
1147	N-linked (GlcNAc...) asparagine	UniProt
1152	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Collagen biosynthesis and modifying enzymes	Mus musculus
O-glycosylation of TSR domain-containing proteins	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements