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Cholesterol transporter ABCA5

Summary

UniProt ID: Q8CF82
Gene Symbol: Abca5
Gene ID: 286970
Organism: Rattus norvegicus (Norway rat)

External Links

PubChem: Q8CF82
Re-Glyco: Q8CF82

Annotation

Keyword: ATP-binding Alternative splicing Cell membrane Endosome Glycoprotein Golgi apparatus Lipid transport Lysosome Reference proteome Repeat Translocase Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	Reference
lipid transport
cholesterol metabolic process	ISS	GO_REF
cholesterol metabolic process	ISO	GO_REF
cholesterol metabolic process	IEA	GO_REF
negative regulation of macrophage derived foam cell differentiation	ISO	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

multicellular organismal process [inference]

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

high-density lipoprotein particle remodeling

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport

sterol transport

cholesterol transport [inference]

organic hydroxy compound transport [inference]

sterol transport

cholesterol transport [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

regulation of cholesterol transport [inference]

regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

regulation of reverse cholesterol transport [inference]

positive regulation of reverse cholesterol transport

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

regulation of cholesterol transport [inference]

regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

regulation of reverse cholesterol transport [inference]

positive regulation of reverse cholesterol transport

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of reverse cholesterol transport

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

regulation of cellular process [inference]

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
Golgi membrane	IEA	GO_REF
lysosome	ISO	GO_REF
lysosome	IEA	GO_REF GO_REF
lysosomal membrane	IEA	GO_REF
late endosome	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

late endosome membrane

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

Displaying **all 5** entries
GO Term	Evidence Code	Reference
lipid carrier activity
ATP binding	IEA	GO_REF
ATP hydrolysis activity	IEA	GO_REF
ATPase-coupled transmembrane transporter activity	IBA	GO_REF
ABC-type transporter activity	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular carrier activity [inference]

lipid carrier activity

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MATAIRDVGVWRQTRTLLLKNYLVKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVSDIELSPMDKSILSNLILGYTPVTNTTSSVMQRVSTDHLPDVLVTEEYASEKELLASSLSKPSNFVGVVFKDVMSYELRFFPDMVPVSSVYMDSRAGCSKSCDAAQYWSSGFTALQASIDAAIIQLKTNVSLWRELESTKAVIMGEAAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKRLKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASSLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGVVEFFVTVVFGFVGLLIVLVESFPRSLVWLFSPLCQCAFLIGIAQVMHLEDFNEGALFSSLTEGPYPLIITLTMLALDSVFYALLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKNKRNYKELSEGNINGNISLNEIVEPVSSEFIGKEAIRISGIQKAYRKKNETVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQSDMNFDVLTVEENLSILASVKGIPANNIIQEVQKVLLDLDMQAIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSIFLKSKWGIGYRLSMYIDRYCATESLSSLVRQHIPAAALLQQNDQQIVYSLPFKDMDKFSGLFSALDIHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPREEETDSKSFDEMEQSLLILSETKASLVSTMSLWKQQVSTIAKFHFLSLKRESKSVRSVLLLLLIFFAVQIFMFLVHHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTSLLLQNSTDSDINDLIDFFTQQNIIVAMFNDSDYVSAAPHSAALNVVQSEKDYVFTAVFNSTMVYSLPVMMNIISNYYLYHLNVTDTIQIWSTPFIQEITDIVFKVELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFVVLTLMLGSLFAFHHGLYFYPVKFLAVVFCLIAYVPSVILFTYIASFTFKKILNTKEFWSFIYSVTALACVAVTEITFFLGYGVTAVFHYTFCIAIPIYPLLGCLISFIKGSWKNIPKTENAYNPWDRLLVAVIMPYLQCVLWIFLLQHYEKKHGGRSIRKDPLFRALSQKAKHKKFPEPPINEDEDEDVKAERLKVKELMGCQCCEEKPAIMVYNLHKEYDDKKDFLHSRKTTKVATKYVSFCVKKGEILGLLGPNGAGKSTIINILVGDVEPTSGKIFLGDYGSHSNEDDESTKCMGYCPQTNPLWPDITLQEHFEIYGAVKGMSSGDMKEVISRITKALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQVTLLDEPSTGMDPRAKQHMWRAIRTAFKNKKRAALLTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEIDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFAKLEEAKHTFAIEEYSFSQATLEQVFVELTKEQEEEDNSCGTLNSTLWWERRQEDRVVF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	Source
86	N-linked (GlcNAc...) asparagine	UniProt
190	N-linked (GlcNAc...) asparagine	UniProt
458	N-linked (GlcNAc...) asparagine	UniProt
919	N-linked (GlcNAc...) asparagine	UniProt
996	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
ABC transporters in lipid homeostasis	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements