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Voltage-dependent calcium channel subunit alpha-2/delta-2
Summary
- UniProt ID
- Q8CFG6
- Gene Symbol
- Cacna2d2
- Gene ID
- 300992
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
- Calcium channel Disulfide bond Glycoprotein Metal-binding Reference proteome Signal Transmembrane helix Voltage-gated channel
Gene Ontology (GO)
| GO Term | Evidence Code | Reference |
|---|---|---|
| calcium ion transport | ||
| neuromuscular junction development | ||
| regulation of multicellular organism growth | ||
| positive regulation of organ growth | ||
| muscle cell development |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| voltage-gated calcium channel complex | ||
| voltage-gated calcium channel complex | ||
| voltage-gated calcium channel complex | ||
| presynaptic active zone membrane | ||
| GABA-ergic synapse |
GO Hierarchy
| GO Term | Evidence Code | Reference |
|---|---|---|
| voltage-gated calcium channel activity | ||
| voltage-gated calcium channel activity | ||
| voltage-gated calcium channel activity | ||
| calcium channel regulator activity | ||
| metal ion binding |
|
|
Sequence
MAVPARTCGASWPGPVRTARPWPGRGPRPCPDPRGPASGPARPLLLLLPPLLLLPLLTAPGASAYSFPQQHTMQHWARRLEQEIDGVMRIFGGVQQLREIYKDNRNLFDVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEEPNFKNKVNYSYTAVQIPTDIYKGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVSCFTHLVQANVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITRANCNKMIMMFTDGGEDRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKDAKQVQWTNVYEDALGLGLVVTGTLPVFNLTQDGPGDKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQITNFREPVTLDFLDAELEDENKEEIRRSMIDGDKGHKQIRTLVKSLDERYIDEVIRNYTWVPIRSTNYSLGLVLPPYSTYYLQANLSDQILQVKLPISKLKDFEFLLPSSFESEGHVFIAPREYCKDLNASDNNTEFLKNFIELMEKVTPDSKQCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEPFNASFYRRSLDNRGYIFKPPHQDSLLRPLELENDTVGVLVSTAVELSLGRRTLRPAVVGVKLDLEAWAEKFKVLASNRTHQDQPQKQCGPSSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTIADFLNLAWWTSAAAWSLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYFGSVNASYNAIIDCGNCSRLFHAQRLTNTNLLFVVAEKPLCSQCEVGRLLQKETHCPADGPEQCELVQRPRYRTGPHICFDYNATEDTSDCGRGASFPPSLGVLVSLQLLLLLGLPPRPQPQIHSFTPSRRL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 205 |
|
|
||
| 389 |
|
|
||
| 421 |
|
|
||
| 510 |
|
|
||
| 543 |
|
|
||
| 627 |
|
|
||
| 864 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Phase 0 - rapid depolarisation | Rattus norvegicus |
| Phase 2 - plateau phase | Rattus norvegicus |
| Presynaptic depolarization and calcium channel opening | Rattus norvegicus |
| Regulation of insulin secretion | Rattus norvegicus |
