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Complement C1r-A subcomponent

Summary

UniProt ID: Q8CG16
Gene Symbol: C1r C1ra
Gene ID: 50909
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q8CG16
PubChem: Q8CG16
Re-Glyco: Q8CG16

Annotation

Keyword: Autocatalytic cleavage Calcium Complement pathway Disulfide bond EGF-like domain Glycoprotein Hydroxylation Metal-binding Phosphoprotein Reference proteome Repeat Secreted Serine protease Signal Sushi

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
activation of membrane attack complex	ISO	GO_REF
complement activation	ISO	GO_REF
complement activation	IEA	GO_REF
complement activation, classical pathway	ISS	GO_REF
complement activation, classical pathway	ISO	GO_REF

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

opsonization

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response

cellular process [inference]

cell killing [inference]

killing of cells of another organism

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation

protein processing [inference]

zymogen activation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation

protein processing [inference]

zymogen activation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
complement component C1 complex	ISS	GO_REF
complement component C1 complex	ISO	GO_REF
complement component C1 complex	NAS	PMID
obsolete extracellular space
cell surface	ISS	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

extracellular protein-containing complex [inference]

complement component C1 complex

cellular anatomical structure [inference]

cell surface

other organism part [inference]

symbiont cell surface

blood microparticle

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
serine-type endopeptidase activity	ISS	GO_REF
serine-type endopeptidase activity	ISO	GO_REF
serine-type endopeptidase activity	IBA	GO_REF
serine-type endopeptidase activity	IEA	GO_REF GO_REF
calcium ion binding	ISO	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular sequestering activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MWLFALLVTLFYGVEGSIYLPQKLYGEVTSPLYPKPYPSDLETTTVITVPMGYRVKLVFWQFDVEPSEGCFYDYVKISADKQTLGRFCGQLDSPLGNPPGSKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASQPNSVEEGLQPRCQHLCHNYVGGYFCSCHPGYELQKDGQSCQAECSSELYTEPSGYVSSLEYPQPYPPDLRCNYSIRVERGLTVHLKFLDPFEIDDHQQVHCPYDQLQIYANGKNLGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLHYTTETIKCPQPKALDEFTIIQDPQPQYQFRDYFIVTCKQGYQLMEGNQALLSFTAVCQNDGTWHRAMPRCKIKNCGQPQSLSNGDFRYITTKGVTTYEASIQYHCHEPYYKMLTRAGSSESMRGIYTCTAQGIWKNEEEGEKMPRCLPVCGKPVNPVTQKERIIRGQPARPGNFPWQAFTTTHGRGGGALLGDRWILTAAHTIYPKHHNKENDNANPKMLVFLGHTNVEQIKKLGHHPVRRVIIHPDYRQDEPNNFEGDIALLELENSVTLGPELLPICLPDNETFYGQGLMGYVSGFGITEDKLAFDLRFVRLPVADSEACQRWLQTKKDTSPFSQNMFCSGDPAVQQDACQGDSGGVFAVRDRNRDIWVATGIVSWGIGCGEGYGFYTKVLNYVDWIKKEMGDEN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	Source
124	N-linked (GlcNAc...) asparagine		UniProt GlyGen
220	N-linked (GlcNAc...) asparagine	17330941	UniProt GlyGen
583	N-linked (GlcNAc...) asparagine		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Classical antibody-mediated complement activation	Mus musculus
Regulation of Complement cascade	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements