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Mannan-binding lectin serine protease 1

Summary

UniProt ID: Q8CHN8
Gene Symbol: Crarf Masp1
Gene ID: 64023
Organism: Rattus norvegicus (Norway rat)

External Links

PubChem: Q8CHN8
Re-Glyco: Q8CHN8

Annotation

Keyword: 3D-structure Alternative splicing Autocatalytic cleavage Calcium Complement activation lectin pathway Disulfide bond EGF-like domain Glycoprotein Hydroxylation Metal-binding Reference proteome Repeat Secreted Serine protease Signal Sushi

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
complement activation, lectin pathway	ISS	GO_REF
complement activation, lectin pathway	ISO	GO_REF
complement activation, lectin pathway	IBA	GO_REF
activation of membrane attack complex
complement activation	NAS	PMID

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

opsonization

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

cellular process [inference]

cell killing [inference]

killing of cells of another organism

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation

protein processing [inference]

zymogen activation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

zymogen activation

protein maturation

protein processing [inference]

zymogen activation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation

regulation of complement activation [inference]

negative regulation of complement activation

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

regulation of complement activation [inference]

negative regulation of complement activation

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

negative regulation of response to stimulus [inference]

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

negative regulation of response to stimulus [inference]

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

regulation of complement activation [inference]

negative regulation of complement activation

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

Displaying **all 5** entries
GO Term	Evidence Code	Reference
obsolete extracellular space
nucleoplasm	ISO	GO_REF
cytosol	ISO	GO_REF
symbiont cell surface	ISS	GO_REF
symbiont cell surface	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

other organism part [inference]

symbiont cell surface

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
serine-type endopeptidase activity	ISS	GO_REF
serine-type endopeptidase activity	ISO	GO_REF
serine-type endopeptidase activity	IDA	PMID
serine-type endopeptidase activity	IBA	GO_REF
serine-type endopeptidase activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

calcium-dependent protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRFLSFRRLLLYHVLCLTLTEVSAHTVELNEMFGQIQSPGYPDSYPSDSEVTWNITVPEGFRVQLYFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSVTFRSDFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSGNLFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVTLQFEDIFDIEDHPEVPCPYDYIKIKAGSKVWGPFCGEKSPEPISTQSHSIQILFRSDNSGENRGWRLSYRAAGNECPKLQPPVYGKIEPSQAVYSFKDQVLISCDTGYKVLKDNEVMDTFQIECLKDGAWSNKIPTCKIVDCGVPAVLKHGLVTFSTRNNLTTYKSEIRYSCQQPYYKMLHNTTGVYTCSAHGTWTNEVLKRSLPTCLPVCGLPKFSRKHISRIFNGRPAQKGTTPWIAMLSQLNGQPFCGGSLLGSNWVLTAAHCLHHPLDPEEPILHNSHLLSPSDFKIIMGKHWRRRSDEDEQHLHVKHIMLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEHPSTEGTMVIVSGWGKQFLQRLPENLMEIEIPIVNYHTCQEAYTPLGKKVTQDMICAGEKEGGKDACAGDSGGPMVTKDAERDQWYLVGVVSWGEDCGKKDRYGVYSYIYPNKDWIQRVTGVRN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	PubMed ID	Source
54	N-linked (GlcNAc...) asparagine	28111019	UniProt
183	N-linked (GlcNAc...) asparagine	28111019	UniProt
390	N-linked (GlcNAc...) asparagine		UniProt
412	N-linked (GlcNAc...) asparagine		UniProt
538	N-linked (GlcNAc...) asparagine (In isoform Q8CHN8-2)		UniProt
604	N-linked (GlcNAc...) asparagine (In isoform Q8CHN8-2)		UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Ficolins bind to repetitive carbohydrate structures on the target cell surface	Rattus norvegicus
Lectin pathway of complement activation	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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