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Prostaglandin G/H synthase 1

Summary

UniProt ID: Q8HZR1
Gene Symbol: COX1 PTGS1
Gene ID: 403544
Organism: Canis lupus familiaris (dog)

External Links

PubChem: Q8HZR1
Re-Glyco: Q8HZR1

Annotation

Keyword: Alternative splicing Dioxygenase Disulfide bond EGF-like domain Glycoprotein Heme Membrane Microsome Peroxidase Prostaglandin biosynthesis Reference proteome Signal

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	Reference
response to oxidative stress	IEA	GO_REF
cyclooxygenase pathway	IBA	GO_REF
cyclooxygenase pathway	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonate metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonate metabolic process [inference]

cyclooxygenase pathway

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonate metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonate metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonate metabolic process [inference]

cyclooxygenase pathway

olefinic compound metabolic process [inference]

arachidonate metabolic process [inference]

cyclooxygenase pathway

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

Displaying **all 5** entries
GO Term	Evidence Code	Reference
cytoplasm	IBA	GO_REF
cytoplasm	IEA	GO_REF
endoplasmic reticulum membrane	IEA	GO_REF
neuron projection	IBA	GO_REF
neuron projection	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
peroxidase activity	IEA	GO_REF
prostaglandin-endoperoxide synthase activity	ISS	GO_REF
prostaglandin-endoperoxide synthase activity	IBA	GO_REF
prostaglandin-endoperoxide synthase activity	IEA	GO_REF GO_REF GO_REF
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

prostaglandin-endoperoxide synthase activity

dioxygenase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSRGSRLHRWPLLLLLLLLLPPPPVLPAEARTPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPELWTWLRNSLRPSPSFLHFLLTHGRWFWEFINATFIRDMLMRLVLTARSNLIPSPPTYNIAHDYISWESFSNVSYYTRVLPSVPQDCPTPMGTKGKKQLPDAQLLGRRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLDRQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGILPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFSAQFQYRNRIAMEFNQLYHWHPLMPDSFWVGSQEYSYEQFLFNTSMLTHYGIEALVDAFSRQSAGRIGGGRNIDHHVLHVAVETIKESRELRLQPFNEYRKRFGMRPYMSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEMGFNMVKTATLKKLVCLNTKTCPYVSFRVPDPHQDGGPGVERPSTEL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
71	N-linked (GlcNAc...) asparagine	UniProt
107	N-linked (GlcNAc...) asparagine	UniProt
147	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
COX reactions	Canis familiaris
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Canis familiaris

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

International Collaboration

Acknowledgements